The Coyolxauhqui Imperative: Dismemberment and Sacred Reintegration in Decolonial Psychiatry.

The Coyolxauhqui Imperative offers a decolonial framework for reimagining trauma and healing in psychiatric practice by drawing on the Aztec myth of Coyolxauhqui's dismemberment and celestial transformation. Challenging Western biomedical assumptions of linear recovery and pathologization of fragmentation, this paradigm centers cultural epistemologies of nepantla (liminal space), conocimiento (embodied truth-telling), and mythic temporality (cyclical reintegration). Through critical analysis of Nahuatl cosmology, Gloria Anzaldúa's theoretical expansion, and contemporary ritual practices, the model reconceives psychological crises as sacred processes of disintegration and reassembly.

The potential mediating role of depression on medical mistrust and mental health service use in Black adults.

Background: Major depressive disorders are ranked third in the global burden of disease by the World Health Organization. The association between mistrust in Black adults and its effect on health service utilization is well established. However, research on mistrust and specific utilization of mental health services is limited.

Formulation and Characterization of Bone-Targeting Vancomycin-Loaded Liposomes.

We report the successful formulation of a bone-targeted vancomycin-loaded liposomal carrier. The basic liposomal structure is composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and dicetyl phosphate (DCP) in a molar ratio of 3:1:0.25, respectively.

Corrigendum to: "An Overview of Conventional Drugs and Nanotherapeutic Options for the Treatment and Management of Pediatric Acute Lymphoblastic Leukemia".

The author has identified an error in the author's name in an article titled "An Overview of Conventional Drugs and Nanotherapeutic Options for the Treatment and Management of Pediatric Acute Lymphoblastic Leukemia," published in Anti-Cancer Agents in Medicinal Chemistry, 2022, 18, 3050-3061 [1]. Details of the error and a correction are provided here. ORIGINAL: Andre Yohan Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 19 Foster Street, Worcester, MA 01608, USA CORRECTED: Andre Yonan Department of Pharmaceutical Sciences, School of Pharmacy, MCPHS University, 19 Foster Street, Worcester, MA 01608, USA We regret the error and apologize to readers.

Triple co-culture spheroid models of lung and ovarian carcinoma cell lines for the testing of antitumor liposomes.

Tumor cells cultured as spheroids have been shown to be superior to tumor cells cultured in monolayers as models of solid tumors because they exhibit features of the tumor microenvironment (TME) such as cell-cell interactions, extracellular matrix and diffusional gradients. However, spheroids composed solely of tumor cells, i.e.

Allergy alerting and overrides for opioid analogues across two health systems.

Objectives: Despite opioids comprising a majority of drug allergy alert (DAA) overrides, few studies have designed recommendations for clinical decision support (CDS) systems. We determined the frequency of opioid analogue DAA overrides and assessed DAAs overridden by patient and provider type, the most common allergic reactions documented in electronic health records (EHR), reaction severity, and associated hypersensitivity.

Methods: We conducted an observational cross-sectional study of DAAs in two geographically remote health systems.

Getting to the information clinicians need quickly: Pharmacist evaluation of DynaMed and micromedex with watson (DynaMedex) using real-world questions.

Introduction: Digital point-of-care information resources are frequently used by clinicians to answer clinical questions. An evidence-based disease management database (DynaMed) was merged with a pharmaceutical knowledge base (Micromedex). We evaluated the ability of the combined solution, DynaMedex, to answer clinical questions.

Evaluation of bony fusion after anterior cervical discectomy: a systematic literature review and meta-analysis.

Significant variability exists in reported fusion rates in the cervical spine after anterior discectomy. Here we review fusion assessment methods, timing of fusion with various intervertebral devices, and examine correlations with clinical outcomes. PubMed, Medline, Embase, Web of Science, Cochrane Library, and Emcare were searched on December 9 2024 for studies involving 1- or 2-level anterior cervical discectomy with quantitative fusion assessment via CT or X-ray.

Prolonged glucocorticoid use and rheumatoid arthritis-associated cervical spine deformity.

Objectives: RA patients are often prescribed glucocorticoids, although it is known that their long-term use increases the risk of osteoporosis and fractures. The association between glucocorticoid use and RA-associated cervical spine deformity is yet to be determined.

Method: Duration and dose of glucocorticoid use were evaluated in patients with new onset RA (BeSt Trial).

Infliximab use and cervical spine deformity in patients with rheumatoid arthritis.

Objective: Over the past decades, the incidence of surgery for rheumatoid arthritis (RA)-associated cervical spine deformity decreased. Infliximab has been observed as a protective treatment for joint damage in hands and feet; yet, the protective association between infliximab and the cervical spine has been uncertain.

Methods: Duration of infliximab use during 10 years of follow-up was evaluated in patients with new-onset RA (case control study using data from the BeSt Trial).

N,N'-bis(2-mercaptoethyl)isophthalamide (NBMI) as a novel chelator for Wilson's disease.

Wilson's Disease (WD) is a rare autosomal recessive disorder caused by mutations in the ATP7B gene. These mutations lead to defective copper (Cu) transport and to accumulation of Cu in tissues, primarily in the liver and brain. Current treatment options such as D-penicillamine, trientine, and zinc salts focus on increasing Cu excretion or reducing Cu absorption, but often cause debilitating side effects.

The Pharmacist's Role in the Care of Pediatric Emergency Department Patients.

The Pediatric Pharmacy Association (PPA) strongly urges health care institutions to establish and support the pharmacist's role in pediatric emergency department (ED) settings. Adult patient-centric guidelines have firmly established the general role of the pharmacist and pharmacy services in emergency medicine; however, pediatric pharmacy presence is often considered in case-based scenarios, such as pediatric cardiopulmonary resuscitation events. PPA recommends supporting the pharmacist's role in all pediatric ED settings and scenarios including, but not limited to, participation in direct patient care activities, education, safety, improvement initiatives, and transitions of care.

Development of a drug allergy alert tiering algorithm for penicillins and cephalosporins.

Introduction: Limited research is available regarding recommendations about which drug allergy alerts (DAAs) in clinical decision support (CDS) systems should interrupt provider workflow. The objective was to evaluate the frequency of penicillin and cephalosporin DAA overrides at two institutions. A secondary objective was to redesign DAAs using a new tiered alerting system based on patient factors.

Cardiovascular and Metabolic Adverse Events of Endocrine Therapies in Women with Breast Cancer: A Disproportionality Analysis of Reports in the FDA Adverse Event Reporting System.

Introduction: Emerging evidence suggests potential cardiovascular toxicities from oral endocrine therapies (ETs); however, results are conflicting. This study comprehensively examined adverse reactions of ETs and investigated cardiovascular and metabolic safety signals within the FDA Adverse Event Reporting System (FAERS).

Methods: Reports in the FAERS through December 2023 were analyzed for documented reactions to tamoxifen, letrozole, anastrozole, and exemestane in female breast cancer patients.

Modular self-emulsifying drug delivery platform to enhance cellular uptake activity in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) presents with resistance phenotypes to certain therapies, such as cisplatin, often requiring higher dosing, with associated acquired tumor resistance, renal toxicity, and variable patient responses. A self-emulsifying drug delivery (SEDD) formulation approach was proposed to overcome the limitations of cisplatin in TNBC, focusing on improving intracellular cisplatin and control siRNA uptake as a proof-of-principle of dual drug delivery. Four SEDD formulations were prepared and optimized for cisplatin (o/w) emulsion and FITC-siRNA (w/o) emulsion using pseudo-ternary phase diagrams to facilitate the formation of water-in-oil-water (w/o/w) emulsions.

Practical and statistical aspects of subgroup analyses in surgical neuro-oncology: A comprehensive review from the PIONEER consortium.

Subgroup analyses are essential to generate new hypotheses or to estimate treatment effects in clinically meaningful subgroups of patients. They play an important role in taking the next step toward personalized surgical treatment for brain tumor patients. However, subgroup analyses must be used with consideration and care because they have significant potential risks.

Preceptor perspectives on disability-related accommodations in pharmacy experiential education.

Introduction: Accreditation Council for Pharmacy Education Standards require reasonable accommodation for students with disabilities in an educational setting. There is limited information regarding preceptor experiences and perspectives associated with accommodations in the pharmacy experiential learning environment. This study examined preceptor experiences and viewpoints and explored opportunities for schools/colleges of pharmacy (S/COP) to provide support and education for preceptors when meeting access needs.

Intraprofessional Education Experiences in Dentistry: Dental hygienists' perceptions of collaboration with dentists.

Health care professionals (HCPs) working collaboratively can improve patient outcomes and also increase their understanding of each other's professional roles. This descriptive study aimed to explore dental hygienists' perceptions of collaboration with dentists and intraprofessional educational (IntraPE) experiences. A convenience sampling method was used to assess DHs perceptions of collaboration with dentists using the Interprofessional Collaboration Scale (ICS), a validated scale that measures perceptions of communication, accommodation, and isolation among HCPs.

An Introductory Guide to Survey Research.

In the dental hygiene discipline, evidence-based practice serves as a cornerstone for delivering high quality patient care and moving professional standards forward. As practitioners delve deeper into research to inform clinical decision making, the integration of robust survey methodologies becomes imperative. However, the complexities of survey design, implementation, and analysis pose notable challenges, particularly in ensuring the reliability and validity of research outcomes.

Transferrin-Conjugated Nanostructured Lipid Carriers for Targeting Artemisone to Melanoma Cells.

We report a successful formulation of Artemisone (ATM) in transferrin (Tf)-conjugated nanostructured lipid carriers (NLCs), achieving nearly a five-times increase in cell toxicity. The escalating cost of new drug discoveries led to the repurposing of approved drugs for new indications. This study incorporated Artemisone, an antimalarial drug, into a nanostructured lipid carrier (NLC) and tested for possible anticancer effects.

Occupational inequalities in mortality from cardiovascular disease, 2020-2021.

Background: In recent years previous declines in cardiovascular disease (CVD) have stalled. There are occupational risk factors for CVD mortality. This study seeks to examine inequalities in CVD mortality for working-age adults in the United States by occupation.

Alcohol consumption in relation to cognitive dysfunction and dementia: A systematic review and dose-response meta-analysis of comparative longitudinal studies.

Background: Alcohol use is associated with a wide spectrum of neurological disorders, including cognitive dysfunction and dementia. Likewise, the high prevalence of cognitive dysfunction and dementia specifies the urgent need to identify modifiable risk factors. Because findings on alcohol and cognitive dysfunction and dementia have been inconsistent, the present dose-response meta-analysis of cohort and case control studies was conducted to evaluate the available evidence.