Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells.

The gene locus coordinates body patterning, hematopoiesis, and differentiation. While studying blood phenotype-associated variation within the locus, we identified a genetic variant, rs17437411, associated with globally reduced blood counts, protection from blood cancers, and variation in anthropometric phenotypes. We find that this variant disrupts the activity of a previously unstudied antisense long non-coding RNA (lncRNA) located between and , which we have named .

Multimedia Approach to Living Donation Education for Transplant Professionals: Building a Professional Society Multimedia Work Group.

Purpose Of Review: Currently, there are number of initiatives underway across the world to remove barriers and increase education about living donation and living donor transplantation, including among professionals. Widespread use of the internet and social media (SoMe) started a new era of online information sharing. Extensive studies have highlighted the significant role of visual abstracts (VAs) and infographics in disseminating medical information including related to donation and transplantation.

Factors predicting cosmesis, late effects (LEs) and patient reported measures (PROMs) in high-risk breast cancer (BC) treated with hypo-fractionated whole breast radiotherapy (HF-WBI): real world outcomes from a developing country.

Background: Breast cancer (BC) in low-middle income country commonly presents as large operable/locally advanced BC (LO/LABC). Advances in treatment have gradually increased the probability of breast conservation in this population. Hypo-fractionated whole breast radiotherapy (HF-WBI) has become the standard of care.

ProInflammatory Cytokines in Patients With Thyroid Nodules Before, During, and After Thyroidectomy in a Tertiary Referral Center.

Background: Thyroid nodules are epidemic in certain countries. Advancements in imaging technology and increased healthcare screening have led to a notable rise in their detection. This surge in detection has also sparked a renewed focus on understanding their pathophysiology.

Practices and diversities in plexus and peripheral nerve blocks: A survey.

Background And Aims: Regional anesthesia plays a crucial role in perioperative medicine, influencing both immediate and long-term outcomes. However, there is a lack of data regarding the utilization and practices of plexus and peripheral nerve blocks. We attempted to investigate the practices of plexus and peripheral nerve blocks using a validated questionnaire.

Efficacy, Tolerability, and Safety of Glucagon-Like Peptide 1 Receptor Agonists (GLP1-RA) in Kidney Transplant Recipients With Diabetes.

Introduction: Uncontrolled diabetes after solid-organ transplantation has been associated with weight gain, high cardiovascular mortality, and transplant rejection. The current standard of care for uncontrolled diabetes after KT is insulin. Recently GLP1-RA have been proposed as an adjuvant medication for those with obesity, but there are concerns for side effects and safety.

A non-invasive way to enhance cosmetic efficacy by associating a cosmetic serum with a nanochip tapping.

Background: Skincare cosmetics have long been central to daily facial care routines, while recent years have seen a surge in the popularity of home beauty devices. Consumers increasingly seek more effective and efficient results from their beauty regimens while also expressing concerns about the potential risks of certain beauty procedures. Although various technological devices have been developed to meet these demands, research on the interactions between beauty devices and cosmetic products remains limited.

Inherited resilience to clonal hematopoiesis by modifying stem cell RNA regulation.

Somatic mutations that increase hematopoietic stem cell (HSC) fitness drive their expansion in clonal hematopoiesis (CH) and predispose to blood cancers. Although CH frequently occurs with aging, it rarely progresses to overt malignancy. Population variation in the growth rate and potential of mutant clones suggests the presence of genetic factors protecting against CH, but these remain largely undefined.

Review: Fructose, the Sweet Culprit behind Nonalcoholic Fatty Liver Disease and Type 2 Diabetes.

The composition of the diet has altered over the past few decades, with a significant increase in the consumption of dietary sugars, particularly fructose, which has risen more than tenfold. This elevated consumption of fructose and sugars is considered to be one of the major risk aspects for the emergence of obesity and other metabolic disorders. In this review, we discuss the correlation between insulin resistance and NAFLD (nonalcoholic fatty liver disease) due to dietary fructose intake.

Fetal Autopsy in Stillbirth: Its Acceptance and Role in Determining the Causes and Risk Factors in North India.

Background: Stillbirth is a major global health issue. The fetal autopsy is considered one of the primal diagnostic tools to determine the cause of stillbirth over MRI, ultrasound, and genetic testing. It is often the way to obtain a definitive diagnosis and can be helpful for families who are grieving the loss of a pregnancy.

Challenging Perioperative Management of a MEN2A Syndrome Patient Complicated by Eisenmenger Syndrome.

Multiple endocrine neoplasia type 2A (MEN2A), is associated with pheochromocytoma and medullary carcinoma of the thyroid. A surgical procedure in these patients can be complicated if they have any congenital heart disease (CHD). Nowadays, CHD patients are increasingly presenting at advanced age for non-cardiac surgeries, posing unique challenges to anesthesiologists.

Efficacy and Safety of Tyrosine Kinase Inhibitors in Downstaging and Palliation in Patients with Advanced Differentiated Thyroid Cancer - A Multicentre study.

Thyroid cancer (TC) is the most common endocrine malignancy worldwide, with differentiated thyroid cancer (DTC) comprising the majority of cases. Surgical treatment of locally advanced DTC can be challenging, prompting the exploration of tyrosine kinase inhibitors (TKIs) to downstage the disease burden before surgery. Sorafenib and Lenvatinib have shown promising response rates in managing refractory DTC.

Differentiation success of reprogrammed cells is heterogeneous in vivo and modulated by somatic cell identity memory.

Nuclear reprogramming can change cellular fates. Yet, reprogramming efficiency is low, and the resulting cell types are often not functional. Here, we used nuclear transfer to eggs to follow single cells during reprogramming in vivo.

High-resolution genetic and physical mapping reveals a peanut spotted wilt disease resistance locus, PSWDR-1, to Tomato spotted wilt virus (TSWV), within a recombination cold-spot on chromosome A01.

Background: Peanut (Arachis hypogaea L.) is a vital global crop, frequently threatened by both abiotic and biotic stresses. Among the most damaging biotic stresses is Tomato spotted wilt virus (TSWV), which causes peanut spotted wilt disease resulting in significant yield loss.

A Review on Medicinal Approaches of Novel Imatinib Derivatives.

Phenyl amino pyrimidine attracts researchers due to its versatile scaffold and medicinal significance. This significant moiety present in the Imatinib contributed to medicinal chemistry. In this manuscript, we reviewed various derivatives of Imatinib containing 2-phenylaminopyrimidine, which has a variety of roles, especially in the anti-cancer category.

HuD regulates apoptosis in N2a cells by regulating Msi2 expression.

HuD plays a critical role in neurite outgrowth, neuronal plasticity, and survival. However, HuD autoantibodies from patients with paraneoplastic gut dysmotility can trigger the apoptotic cascade in human neuroblastoma cell line and myenteric neurons. The mechanism by which HuD regulates the apoptotic pathway is unclear.

Adductor canal block (ACB) plus infiltration of the posterior capsule of the knee (iPACK) block versus 4-in-1 block in an arthroscopic anterior cruciate ligament (ACL) repair: A randomised study.

Background And Aims: Anterior cruciate ligament (ACL) repair is a common sports-related surgery requiring early rehabilitation. Injection between the popliteal artery and the capsule of the knee (iPACK) provides analgesia to the posterior knee and, when combined with adductor canal block (ACB), can provide complete analgesia for knee surgery. A 4-in-1 block, a single injection, has been studied for analgesia in TKR but not ACL repair.

A Novel Approach for Improving XML Querying over Wireless Broadcast Channels.

The querying of large XML data over wireless broadcast channels can reduce bandwidth utilization, cause significant latency, and produce inefficient energy usage. This paper proposes a scheme to improve XML querying over wireless broadcast channels in order to address the issues mentioned above. Various techniques, including partitioning, load balancing, and query routing, have been combined into one approach.

The Relative Risk of COVID-19 in Solid Organ Transplant Recipients Over Waves of the Pandemic.

Solid organ transplant recipients (SOTR) are at increased risk from COVID-19. Over time, the absolute risk of adverse outcomes after COVID-19 has decreased in both the non-immunosuppressed/immunocompromised (non-ISC) general population, and amongst SOTR. Using the N3C, we examined the absolute risk of mortality, major adverse renal or cardiac events, and hospitalization after COVID-19 diagnosis amongst non-ISC and SOTR populations over five waves of the pandemic (Wave 1: Ancestral COVID; Wave 2: Alpha; Wave 3: Delta; Wave 4: Omicron; Wave 5: Omicron).

Outcomes of Kidney Transplantation in Highly HLA-Sensitized Patients Treated with Intravenous Immuno-Globulin, Plasmapheresis and Rituximab: A Meta-Analysis.

(1) Background: We aimed to investigate the outcomes of human leukocyte antigen (HLA)-incompatible transplantation for patients who received desensitization with intravenous immunoglobulins (IVIg), plasmapheresis, and rituximab. (2) Methods: A comprehensive search of multiple electronic databases to identify studies that utilized desensitization was conducted. The random-effects model was used to calculate the pooled rates and the 95% confidence interval (CI).

Extreme phenotype sampling and next generation sequencing to identify genetic variants associated with tacrolimus in African American kidney transplant recipients.

African American (AA) kidney transplant recipients (KTRs) have poor outcomes, which may in-part be due to tacrolimus (TAC) sub-optimal immunosuppression. We previously determined the common genetic regulators of TAC pharmacokinetics in AAs which were CYP3A5 *3, *6, and *7. To identify low-frequency variants that impact TAC pharmacokinetics, we used extreme phenotype sampling and compared individuals with extreme high (n = 58) and low (n = 60) TAC troughs (N = 515 AA KTRs).

Bioflavonoid combination attenuates diabetes-induced nephropathy in rats via modulation of MMP-9/TIMP-1, TGF-β, and GLUT-4-associated pathways.

Background: Diabetic nephropathy represents a significant microvascular complication of diabetes, characterized by extracellular matrix accumulation, loss of cell-cell junctions, microalbuminuria, and diminished creatinine clearance. Despite its prevalence, therapeutic options dedicated to this condition are currently lacking. Natural products like bioflavonoids have garnered attention for their potential therapeutic benefits.