Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
HuD plays a critical role in neurite outgrowth, neuronal plasticity, and survival. However, HuD autoantibodies from patients with paraneoplastic gut dysmotility can trigger the apoptotic cascade in human neuroblastoma cell line and myenteric neurons. The mechanism by which HuD regulates the apoptotic pathway is unclear. Apoptosis is one of the underlying causes of neurodegenerative diseases like Alzheimer's disease. In the current study, we found that HuD interacts with Msi2 transcript and positively regulates it in the mouse neuroblastoma (N2a) cells. MSI2 being an RNA binding protein has diverse mRNA targets and regulates the mitochondrial apoptotic pathway by interacting with and repressing APAF1 transcript. Conversely, the reduced levels of HuD leads to decreased Msi2 expression and increased APAF1 levels, which results in apoptosis in N2a cells. Overall, our research indicates that HuD and Msi2 possess an anti-apoptotic role in N2A cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11649143 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0315535 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Thionine modulates tau phosphorylation in an Alzheimer's disease cell culture model.
Turk J Biol
June 2025
Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, Turkiye.
Background/aim: Tau protein, which is crucial for sustaining the cytoskeletal network by assisting microtubule construction, contributes significantly to the pathophysiology of Alzheimer's disease (AD). The hyperphosphorylation of tau causes it to detach from microtubules (MTs), leading to the formation of neurofibrillary tangles (NFTs) in neurons, which ultimately results in cell death. Thionine (TH), a cationic phenothiazine-structured compound, has been the topic of extensive research due to its interesting physicochemical properties.
View Article and Find Full Text PDF[7]Helicene-backboned quaternary ammonium salts: synthesis, photophysical investigation, and lysosomal tracking.
J Mater Chem B
September 2025
Department of Chemistry, Indian Institute of Technology, Ropar (IIT Ropar), Rupnagar, Punjab - 140 001, India.
Polyaromatic quaternary ammonium salts (PQASs) are of significant interest due to their promising applications in biological and materials sciences. The incorporation of a heteroatom significantly modifies the electronic and chemical properties of these molecules, influencing their absorption and emission characteristics, as well as the HOMO-LUMO gap. Herein, we report the synthesis and photophysical investigation of [7]helicene-backboned quaternary ammonium salts.
View Article and Find Full Text PDFNeuroprotective effect of Urolithin A via downregulating VDAC1-mediated autophagy in Alzheimer's disease.
Acta Histochem
September 2025
Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. Electronic address:
Background: Amyloid β (Aβ) accumulation in the brains of patients with Alzheimer's disease (AD) contributes to cognitive impairment and neuronal damage. Urolithin A (UA), a gut microbiota-derived metabolite of ellagic acid, has been reported to cross the blood-brain barrier to exert anti-inflammatory and anti-oxidation effects in the brain. However, the molecular mechanisms of UA in AD were still unclear.
View Article and Find Full Text PDFN2A, MCF7, and HepG2 Cells Support Intracellular Replication of .
MicroPubl Biol
August 2025
Department of Biomedical Sciences, Quinnipiac University, Hamden, Connecticut, United States.
is a gram-negative, obligate, intracellular bacterial pathogen that causes zoonotic Q fever in humans. In a mammalian host, may infect macrophage, heart, brain, liver, and placental cells. is routinely cultured in HeLa (human cervical) and Vero (African green monkey kidney) cells for research, but these cell types poorly reflect the natural replicative niche.
View Article and Find Full Text PDFSFXN2 contributes mitochondrial dysfunction-induced apoptosis as a substrate of Parkin.
Front Cell Neurosci
August 2025
Hengyang Medical School, University of South China, Hengyang, China.
Introduction: Mitochondria, situated at the center of intricate signaling networks, play crucial roles in maintaining health and driving disease progression. SFXN2, a recently identified member of the mitochondrial transporter family, is localized to the outer mitochondrial membrane and regulates several critical mitochondrial functions, including iron metabolism, heme biosynthesis, bioenergetics, and redox homeostasis. New evidence also suggests a connection between SFXN2 and mitochondrial dysfunction related human diseases such as Parkinson's disease (PD).
View Article and Find Full Text PDF