Formulation and Characterization of Bone-Targeting Vancomycin-Loaded Liposomes.

We report the successful formulation of a bone-targeted vancomycin-loaded liposomal carrier. The basic liposomal structure is composed of 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and dicetyl phosphate (DCP) in a molar ratio of 3:1:0.25, respectively.