The effect of chatbot-supported instruction on nursing students' history-taking questioning skills and stress level: A randomized controlled study.

Background: Comprehensive history-taking is crucial for patient assessment, prioritisation of care, and planning of care. While direct instruction methods effectively explain history-taking processes and components, they provide insufficient opportunities for practice, necessitating the implementation of supplementary teaching strategies.

Objective: This study aimed to examine the effects of AI chatbot-supported history-taking training on nursing students' questioning skills and clinical stress levels.

Development and clinical assessment of a novel AI-based diagnostic model for Hirschsprung's disease.

This study aimed to develop an AI-based diagnostic model for Hirschsprung's disease (HD) using deep learning on contrast enema (CE) images, with the goal of improving diagnostic accuracy while reducing invasiveness. The dataset included 725 CE images from histopathologically confirmed HD patients from 2013 to 2022. Employing Python and PyTorch, a deep learning model based on the YOLOv8 algorithm was trained and validated, emphasizing key metrics like mean average precision (mAP), precision, recall, and F1 score.

The Effects of PLGA Nanoparticles Containing Different Growth Factors on Neural Stem Cell Differentiation and Their Transition Efficiency After Targeting With TRF.

Aims: Nanoparticle-mediated drug delivery systems are being investigated for the controlled release of drugs to treat neurodegenerative diseases (ND). We aimed to investigate the effects of poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) containing different growth factors (GFs) on rat brain-derived neural stem cells (NSCs) in vitro differentiation, providing insights that may contribute to future approaches for treating Parkinson's disease.

Methods: Three different PLGA-NPs loaded with Brain-Derived Neurotrophic Factor (BDNF), Glial-Derived Neurotrophic Factor (GDNF), and Transforming Growth Factor beta 3 (TGF-β3) were developed and characterized in terms of size, zeta potential, encapsulation efficiency, and release profile.

Comparison of the efficacy of mFOLFOX-6 and mDCF regimens in the treatment of metastatic gastric cancer: a multicenter retrospective study.

Background: Metastatic gastric cancer (GC) and gastroesophageal junction (GEJ) cancer are associated with a poor prognosis. Recent advancements in treatment have incorporated trastuzumab, anti-PD-1 agents, and anti-claudin therapies alongside chemotherapy (ChT), significantly improving outcomes. Contemporary studies predominantly employ doublet ChT as the backbone for these regimens, although historically triplet ChT regimens have been favored, particularly in younger patients requiring rapid tumor shrinkage.

Epidemiology and Outcomes of Candida-Associated Osteoarticular Infections: A Multicenter Retrospective Study from Turkey.

This multicentre retrospective study investigated the epidemiology, clinical characteristics, and fluconazole resistance rates of Candida species in osteoarticular infections across Turkey as well as the factors influencing complete recovery. Data were gathered from 73 adult patients diagnosed with proven or probable Candida-associated osteoarticular infections between 2015 and 2025 from 20 healthcare centres. The most common clinical presentation was spondylodiscitis, followed by the involvement of phalangeal bones in the hands and feet.

Assessment of parental health literacy in children referred to pediatric rheumatology for musculoskeletal pain.

Background: Musculoskeletal (MSK) pain is a prevalent chronic condition in children, adversely affecting their physical and emotional well-being. Parental health literacy (HL) is essential for managing children's health needs, yet its role in pediatric MSK pain remains largely unexplored. This study aims to assess HL levels of parents of children with MSK pain.

Bismuth-based heterojunction photocatalysts for antibiotic remediation: A review of tetracycline degradation and mechanistic insights.

The present review focuses on the bismuth-based heterojunction photocatalysts for the degradation of tetracycline (TC) antibiotic. The frequent usage of antibiotics causes several environmental and health concerns due to their widespread occurrence and persistence in aquatic ecosystems. In this context, bismuth-based photocatalysts have extended noteworthy interest for their tunable structures, visible-light activity, suitable band gap energies, and unique physicochemical properties.

Comparative study by FEM of different liners of a transfemoral amputated lower limb.

The mechanical behavior of prosthetic liners significantly influences stress distribution, soft tissue protection, and the overall efficiency of the prosthetic. While extensive research has been conducted on liner materials, the impact of liner thickness (2 mm, 4 mm, and 6 mm) on biomechanical response remains underexplored. This study utilizes finite element analysis in Abaqus to investigate how liner material (Gel vs.

The effect of therapeutic play-based intervention programme applied to earthquake victim preschool children on psychosocial well-being: a randomised controlled trial.

Objectives: Therapeutic play intervention is an effective strategy that can promote cognitive development, reduce anxiety and stress, and increase confidence, enabling children to explore their problems, find solutions, and regulate their emotions. The current study aims to evaluate the effectiveness of the therapeutic play-based intervention program (TOTEM), which was developed to reduce the adverse psychosocial effects of earthquakes in preschool children.

Methods: This study was conducted as a randomised, single-blinded, two-arm trial with a pre-test and post-test control.

Machinability of Basalt and Glass Fiber Hybrid Composites in Dry Drilling Using TiN/TiAlN-Coated Drill Bits.

Drilling-induced damage in fiber-reinforced polymer composite materials was measured excavating four laminates, basalt (B), glass (G) and their two sandwich type hybrids (BGB, GBG), with 6 mm twist drills at 1520 revolutions per minute and 0.10 mm rev under dry running with an uncoated high-speed steel (HSS-R), grind-coated high-speed steel (HSS-G) or physical vapor deposition-coated (high-speed steel coated with Titanium Nitride (TiN) and Titanium Aluminum Nitride (TiAlN)) drill bits. The hybrid sheets were deliberately incorporated to clarify how alternating basalt-glass architectures redistribute interlaminar stresses during drilling, while the hard, low-friction TiN and TiAlN ceramic coatings enhance cutting performance by forming a heat-resistant tribological barrier that lowers tool-workpiece adhesion, reduces interface temperature, and thereby suppresses thrust-induced delamination.

The Relationship Between Systemic Inflammatory Index and Other Inflammatory Markers with Clinical Severity of the Disease in Patients with Parkinson's Disease.

: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra (SN), pathological accumulation of alpha-synuclein, and chronic neuroinflammation. The aim of this study is to evaluate the serum levels of systemic inflammatory markers such as neutrophil-lymphocyte ratio (NLR), neutrophil-HDL ratio (NHR), monocyte-HDL ratio (MHR), platelet-lymphocyte ratio (PLR), IL-6, IGF-1, systemic immune-inflammation index (SII), and systemic inflammation response index (SIRI) in patients with PD, and to analyze the relationship between these markers and the clinical stage of the disease as well as its motor and non-motor symptoms. : Fifty-one patients diagnosed with PD and forty-nine HC matched for age and sex were evaluated prospectively.

Atlas of interventional cardiology 2023: European Society of Cardiology and European Association of Percutaneous Coronary Interventions.

Aims: To provide the most comprehensive assessment to date of interventional cardiology practices across ESC national society member countries, with a focus on infrastructure, procedural volumes, temporal trends (2013-2022), regional disparities, and adherence to guideline-recommended care.

Methods: The third edition of the ESC-EAPCI Atlas presents data from 50 ESC national society member countries, collected through a dedicated 2023 survey of national cardiac societies and interventional working groups. Data were subjected to a rigorous multi-step quality control process to ensure consistency and accuracy.

Idiopathic Granulomatous Mastitis: A Consensus Report on Treatment and Follow-Up Approaches Based on the Turkish Clinical Classification.

Objective: The second consensus study on idiopathic granulomatous mastitis (IGM) aimed to establish treatment options based on the clinical classification proposed in the first consensus, standardize criteria for treatment discontinuation, and develop follow-up protocols.

Method: A structured methodology, identical to the first consensus study, was employed. An 11-member working group of breast surgeons experienced in IGM from various clinics across the country was formed.

Prognostic significance and rationality of regular non-invasive imaging follow-up in Takayasu arteritis: A large multicenter cohort study.

Objectives: To investigate the prognostic significance of regular imaging follow-up in Takayasu arteritis (TAK) and assess its rationality.

Methods: This was a retrospective multicenter cohort study. A total of 204 adult patients with TAK from 11 tertiary centers, and 580 imaging studies of these patients were included to encompass all concurrent clinical and laboratory findings.

Evaluation of the Relationship Between Intake of Proton Pump Inhibitors and Peri-Implant Bone Microstructure by Using Fractal Analysis: A Retrospective Case-Control Study.

Objectives: Proton pump inhibitors (PPIs) have been suggested to influence bone metabolism and osseointegration. This study aimed to assess the long-term effects of PPI usage on trabecular bone patterns around dental implants through fractal analysis of periapical radiographs.

Material And Methods: This retrospective, matched case-control study analyzed a database of 27 PPI users (87 dental implants) and established a control group of 27 nonusers (88 dental implants), matching them by age, sex, smoking status, total follow-up duration, and history of augmentation procedures.

Enhanced vs. standard low dose dexamethasone treatment on respiratory outcomes of preterm infants with bronchopulmonary dysplasia.

Background: Premature infants are particularly vulnerable to complications such as bronchopulmonary dysplasia (BPD). Although systemic steroids have been used for some time, no effective alternative treatments have emerged. This has led clinicians to investigate various dosing regimens and discuss the necessity of revising systemic steroid dosages.

DHEA-carbamate derivatives as dual cholinesterase inhibitors: Integration of enzymatic and biomolecular interactions in Alzheimer's disease.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and cholinergic dysfunction. Given the limitations of current acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors, novel multi-target drug candidates are urgently needed. In this study, a series of DHEA-carbamate derivatives were rationally designed and synthesized to integrate cholinesterase inhibition with potential neuroprotective and pharmacokinetic advantages.

European Consensus on Functional Bloating and Abdominal Distension-An ESNM/UEG Recommendations for Clinical Management.

Introduction: Abdominal distension is an objective visible sign of increased abdominal girth. Bloating is a feeling of abdominal fullness and discomfort. Bloating may be associated or not with abdominal distension.

Purely endoscopic endonasal resection of extracranial trigeminal schwannomas: a descriptive systematic review and institutional case series.

Background: Trigeminal schwannomas (TSs) are uncommon, benign tumors that arise from the trigeminal nerve. They can spread to the middle cranial fossa, posterior fossa, and extracranially (pterygopalatine fossa (PPF), infratemporal fossa, orbita). Among these, extracranial involvement is the least frequent.

Long-term retinal microvascular alterations after endoscopic endonasal surgery in patients with sellar region tumors.

Aim: To evaluate retinal microcirculation changes at the 3 and 12 months following endoscopic endonasal surgery in patients with sellar region tumors using optical coherence tomography angiography (OCT-A).

Methods: This prospective longitudinal observational study included 78 eyes of 39 patients with sellar tumors and 78 eyes of 39 age- and gender-matched healthy controls. Standard automated perimetry and OCT-A were performed preoperatively and at 3- and 12-month follow-ups.

Molecular Interaction of the Coumarin Derivative Umbelliferone with Cu/Zn-SOD1 and DNA: Insights into Binding Mode and Antioxidant Mechanism.

A member of the coumarin family, umbelliferone is a naturally abundant compound known for its diverse pharmacological and therapeutic properties. Therefore, to gain insight into its molecular recognition mechanism, we plan to conduct an in-depth investigation of its interactions with calf thymus DNA (CT-DNA) and Cu/Zn superoxide dismutase enzyme (SOD1) through a combination of spectroscopic techniques and computational modeling. Results from competitive displacement experiments with EB and Hoechst 33,258, supported by molecular docking analyses, indicate that the umbelliferone preferentially binds to the minor groove of CT-DNA.

Innovative utilization of organic cabin waste for hydrogen production: A case study at Antalya Airport.

This study suggested a way to produce valuable hydrogen from organic cabin waste collected at Antalya Airport, and it included energy and cost analyses of hydrogen production based on this method. In the proposed model, cabin waste is converted into biogas using anaerobic digestion technology, and hydrogen is produced from the biogas employing steam biogas reforming technology. Based on calculations, approximately 4126 m/day of biogas can be produced from 148 tonnes/day of organic cabin waste.

How early is early for JIA? Insights from the infantile-onset juvenile idiopathic arthritis patients of the PERA research group cohort.

Objective: Juvenile idiopathic arthritis (JIA) is the most common chronic childhood arthritis, with distinct categories based on pathophysiology and clinical manifestations. The age of onset varies by category but is reported to be approximately six years. This study aimed to evaluate the clinical, laboratory, and outcome characteristics of patients with the infantile-onset JIA.