Integrated stress response in Behçet disease: expression analyses in peripheral blood and synovial monocytes.

Behçet disease (BD) is a chronic, relapsing inflammatory disorder, and human leukocyte antigen (HLA)-B*51 is considered to be the strongest genetic susceptibility factor. The integrated stress response (ISR), defined by the eIF2α/ATF4 axis, is a signaling network that maintains protein homeostasis and regulates innate immunity in eukaryotic cells; pathological activation of this pathway can affect the immune response and cause various diseases. In this study, we aimed to investigate the role of the ISR signaling pathway in the pathogenesis of BD.

The Validity and Reliability Study of the Turkish Version of Cognitive Complaints in Bipolar Disorder Rating Assessment.

Objectives: The Cognitive Complaints Rating Scale in Bipolar Disorder (COBRA) is a brief self-report measure designed to capture Subjective Cognitive Complaints (SCC) experienced by patients with Bipolar Disorder (BD). This study aimed to translate the 16-item COBRA into Turkish (COBRA-TR) and comprehensively assess its psychometric properties.

Methods: We recruited 160 participants, consisting of 80 BD patients in remission and 80 controls.

Unveiling the Silent Threat: Metabolic Dysfunction-Associated Steatotic Liver Disease Risk in Young Adults Through Noninvasive Assessment.

The global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing, particularly among young adults, posing significant long-term health risks. Early identification of at-risk individuals is crucial for timely intervention and prevention of liver fibrosis. This study aimed to evaluate the prevalence of MASLD in young adults aged 18-30 years and assess the utility of noninvasive fibrosis scores (fibrosis 4 index, AST-to-platelet ratio index [APRI], Hepamet fibrosis score) in risk stratification.

Impact of high-concentration office-type bleaching agent on physical properties of different types of bulk-fill composites.

Background: This study investigated the effect of a 45% carbamide peroxide-containing office-type bleaching agent on the microhardness (MH) and surface roughness (SR) of flowable and paste-type bulk-fill composite resins.

Methods: This study used two bulk-fill composite resins, 3 M Filtek Bulk-Fill (paste) and Estelite Bulk-Fill Flow (flowable). Twenty disc-shaped specimens were prepared and divided into two groups according to the type of bulk-fill materials.

Mathematical Modeling of Aβ-42 Dimerization Dynamics: Integrating Physics-Based Simulations, Graph-Based Variational Autoencoder-Driven Neural Relational Inference, and Chaos Theory.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by the pathological aggregation of amyloid-beta (Aβ) peptides, particularly Aβ-42, which plays a central role in disease progression. Soluble Aβ dimers have been implicated as the primary neurotoxic species contributing to synaptic dysfunction and cognitive impairment. In this study, we employ a comprehensive computational framework integrating molecular dynamics (MD) simulations, neural relational inference (NRI) modeling, and largest Lyapunov exponent (LLE) analysis to elucidate the molecular mechanisms underlying Aβ-42 dimerization and evaluate the inhibitory potential of small molecules, apigenin and caffeine.

Threaded K-wire vs cortical screw fixation in O'Driscoll type 2 and 3 coronoid fractures: a comparative biomechanical study.

Background: Coronoid fractures significantly impact elbow stability, yet limited biomechanical data exists comparing fixation methods for different fracture types. This study aimed to compare the biomechanical performance of threaded K-wire versus cortical screw fixation in O'Driscoll type 2 and 3 coronoid fractures.

Methods: Twenty-eight synthetic ulnar bones were divided into four groups (n = 7 each): Type 2 with K-wire fixation, Type 2 with screw fixation, Type 3 with K-wire fixation, and Type 3 with screw fixation.

Use of Protein Arginine Methyltransferase Inhibitors in Gliomas.

Gliomas are a type of CNS tumors. Protein arginine methyltransferases (PRMTs) play important epigenetic regulatory roles in various cancers, including gliomas, by regulating DNA repair and cellular signaling pathways. Recent studies have also identified overexpression of PRMTs in gliomas and have shown that it is associated with tumor progression and resistance to conventional therapies.

P-Wave dispersion and atrial conduction abnormalities in migraine: implications for cardiovascular risk.

Introduction: Migraine is a common neurological disorder that is increasingly recognized for its systemic effects extending beyond the central nervous system. Emerging evidence suggests a potential association between migraine and cardiovascular dysfunction; however, the underlying pathophysiological mechanisms remain insufficiently elucidated. In this study we aimed to evaluate atrial electromechanical delay in patients with migraine and to test the hypothesis that migraine may be linked to subclinical cardiac alterations, particularly in atrial conduction.

The effect of exercise on menstrual symptoms: a randomized controlled trial.

Background: Menstrual symptoms are a prevalent and frequently encountered woman's health condition. This study aimed to examine the effect of exercise on menstrual symptoms, sleep quality, fatigue, and physical activity levels.

Methods: The study was designed as a randomized controlled trial between September 2023 and December 2023.

Thrombosis Risk in Patients With Mitral Paravalvular Leak: A New Phenomenon in Mechanical Prosthetic Valves.

Background: Mitral regurgitation modifies left atrial (LA) hemodynamics, potentially reducing thrombus formation through the "washout effect." However, the role of paravalvular leaks (PVLs) in thrombus formation remains unclear. In this study we examined the development of thrombosis in patients with mild-moderate and severe mitral PVL.

Purely endoscopic endonasal resection of extracranial trigeminal schwannomas: a descriptive systematic review and institutional case series.

Background: Trigeminal schwannomas (TSs) are uncommon, benign tumors that arise from the trigeminal nerve. They can spread to the middle cranial fossa, posterior fossa, and extracranially (pterygopalatine fossa (PPF), infratemporal fossa, orbita). Among these, extracranial involvement is the least frequent.

A real-time web-based telemedicine framework based on AI and IoMT for emergency triage and initial diagnostics: the TeleMedQuick solution.

Background: Rapid medical decision-making for emergency and chronic conditions remains a global challenge, especially in under-resourced and remote settings. Traditional triage models often rely on narrowly focused algorithms or limited sensor inputs, which can hinder timely diagnosis and treatment.

The Goal Of This Study Is To Introduce Telemedquick: This web-based telemedicine system helps with emergency triage and initial diagnosis by using organised clinical rules based on medical guidelines and approved by doctors.

Long-term retinal microvascular alterations after endoscopic endonasal surgery in patients with sellar region tumors.

Aim: To evaluate retinal microcirculation changes at the 3 and 12 months following endoscopic endonasal surgery in patients with sellar region tumors using optical coherence tomography angiography (OCT-A).

Methods: This prospective longitudinal observational study included 78 eyes of 39 patients with sellar tumors and 78 eyes of 39 age- and gender-matched healthy controls. Standard automated perimetry and OCT-A were performed preoperatively and at 3- and 12-month follow-ups.

Primary central nervous system lymphomas in three "blue books" and correlation of recently defined primary large B-cell lymphoma of immune-privileged sites: Single-center experience.

Background And Objectives: Primary central nervous system lymphomas (PCNSLs) are extranodal non-Hodgkin lymphomas confined to the brain, leptomeninges, eyes, or spinal cord without systemic involvement. The main goal of this study is to examine the incorporation of PCNSLs in three distinct "blue books" (WHO Classification of CNS Tumors [WHO-CNS5], WHO Classification of Hematopoietic and Lymphoid Tissues, Revised 4th edition [WHO-HAEM4R], WHO Classification of Hematolymphoid Tumors, 5th edition [beta version] [WHO-HAEM5-Beta]).

Materials And Methods: Fifteen immunocompetent patients diagnosed with PCNSL between 2016 and 2023 were included in this study.

Effects of chemical surface pretreatments on the surface roughness and shear bond strength of fiber post-resin cement interfaces: a preliminary study.

Background: This preliminary study evaluates the impact of different chemical surface pretreatments on the surface roughness (Ra) of fiber posts and the shear bond strength (SBS) at the interface between the horizontal surface of fiber posts and resin cement, highlighting an area that has not been extensively researched.

Methods: Fifty glass fiber posts (Cytec Blanco, Hahnenkratt) were used, and polishing discs were employed to create a horizontally flat surface. Their dimensions were standardized using a digital caliper and divided into two pieces from each post ( = 20).

Management of Chronic Spontaneous Urticaria Made Practical: What Every Clinician Should Know.

Despite its significant impact on quality of life, optimal management of chronic spontaneous urticaria remains challenging because of knowledge gaps regarding triggers, treatment response variability, and limited data for special populations. Second-generation H1-antihistamines are the first-line treatment and effective in approximately 50% of patients. For those who remain symptomatic, up-dosing up to fourfold is safe and recommended.

Effect of Intermittent Fasting on Anthropometric Measurements, Metabolic Profile, and Hormones in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis.

Background: Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder characterized by excess body weight, hyperandrogenism, hyperglycemia, and insulin resistance often resulting in hirsutism and infertility. Dietary strategies have been shown to ameliorate metabolic disturbances, hormonal imbalances, and inflammation associated with PCOS. Recent evidence indicates that intermittent fasting (IF) could effectively enhance health outcomes and regulate circadian rhythm; however, its impact on PCOS remain unclear.

Exploring the anticancer potential of novel benzimidazolium Salts: Synthesis, biological evaluation, DFT perspective, and docking simulation for inhibition of VEGFR2.

In this study, benzimidazolium salts were designed and prepared in two steps. Synthesized compounds 3a and 3b were evaluated on human cancer cell lines (A549, HepG2, and MCF-7). IC values and selectivity indices were calculated.

Comparison of analgesic efficacy, anti-inflammatory effect, and myotoxicity of ultrasound-guided suprainguinal fascia iliaca block and adductor canal with IPACK combination in patients undergoing total knee arthroplasty under spinal anesthesia: A prospective observational study.

Total knee arthroplasty (TKA) is associated with significant postoperative pain, managed with multimodal analgesia, including regional anesthesia techniques like peripheral nerve blocks. The knee joint's innervation by both sacral and lumbar plexuses often necessitates combined blocks for effective analgesia. This study aimed to compare the effects of suprainguinal fascia iliaca block (SIFIB) and a combination of popliteal artery and posterior knee capsule injection (IPACK) with adductor canal block (ACB) on 24-hour postoperative pain scores, as well as their impact on inflammatory markers and biochemical indicators of myotoxicity.

Neuro-ophthalmology and migraine: visual aura and its neural basis.

Background: Migraine, a chronic neurological condition often accompanied by visual aura, which affects 15-33% of migraineurs, often presents as transient visual disturbances such as scintillating scotoma and teichopsia. These symptoms arise primarily from cortical spreading depression (CSD) within the occipital cortex and significantly impacts the quality of life, with chronic and episodic migraineurs consistently scoring lower scores in vision-specific quality of life questionnaires. Therefore, this narrative review explores the pathophysiology pertaining to visual aura in migraines, focusing on the role of CSD while evaluating current diagnostic and therapeutic approaches employed.

Chemical Characterization, Cytotoxic Activity, and Antimicrobial Potential of Nanoemulsions Based on Essential Oils.

The essential oils (EOs) of (DC.) Stapf are globally recognized for their antimicrobial properties. However, their therapeutic potential is limited by their low solubility and potency.

A pilot single center study in children with enuresis; exploring frequency and charecteristics of monosymptomatic and non-monosymptomatic nocturnal enuresis.

Background: Identifying clinical features that differentiate monosymptomatic nocturnal enuresis (MNE) from non-monosymptomatic nocturnal enuresis (NMNE) would aid in quick diagnosis, which would foster the introduction of early and appropriate therapeutic care options. The aim of this study is to determine whether patients with nocturnal enuresis have more daytime symptoms than reported in the literature.

Methods: In this retrospective study, patients aged 5-18 years who presented with complaints of nocturnal enuresis were evaluated.