Effects of digital physical activity interventions on muscle mechanical function in community-dwelling older adults: a systematic review and meta-analysis.

Aim: To investigate the effect of digital exercise interventions on muscle mechanical function in community-dwelling older adults aged 60 and above.

Methods: Systematic review of randomised controlled trials (RCTs) retrieved from PubMed, EMBASE (Ovid), the Cochrane Central Register of Controlled Trials, and Web of Science until end of March 2024. The Cochrane RoB2.

Determination of Triazole-Derived Fungicides in Fruits, Vegetables, and Their Products by Capillary Electrophoresis with Online Preconcentration Using Field-Amplified Sample Injection.

To determine ametoctradine with five triazole-derived fungicides, a capillary electrophoretic technique in apple, grape, banana, cucumber, tomato, spinach, pepper, carrot, apple juices, grape juices, and red wine was created using 7.5 mM ammonium formate (pH 2.1, 10% v/v, methanol) as a background electrolyte (BGE), and water with 3 s via hydrodynamic injection for the preinjection plug (field-amplified sample injection method).

Effects of recreational football on body composition and blood pressure in sedentary older men: a feasibility study.

Introduction Or Background: Hypertension is a critical health risks that significantly affect the quality of life in older adults. Physical activity programs tailored to the needs of specific populations have proven effective in mitigating these risks.

Sources Of Data: The study employed a single-group pretest-posttest design to evaluate the effects of recreational football interventions on body composition and blood pressure (BP).

Laccase biomonomer crosslinked reusable cryogenic column for synthesis of novel tyrosine-based crosslinker.

This study introduces a reusable cryogenic column system immobilized with laccase enzyme (laccase-M) for the sustainable synthesis of a novel tyrosine-based crosslinker, dityrosine-dimethacrylate (Dityr-diMA). By leveraging methacrylated tyrosine (Tyr-MA) as a biocatalytic platform, the laccase-M column enables efficient polymerization via oxidative coupling, eliminating the need for toxic photoinitiators or metal catalysts. Compared to conventional HEMA-based columns, the laccase-M system achieved a 19.

Cross-Cultural Adaptation and Cutoff Score Determination of the Turkish Version of the Cumberland Ankle Instability Tool in Recreationally Active Individuals.

Background: Adaptation studies have evaluated ankle instability (AI) across various cultures and sports.

Purpose/hypothesis: The Cumberland Ankle Instability Tool (CAIT) is a valid patient-reported outcome measure used to assess the presence and severity of AI. The current study aimed to adapt the CAIT to the Turkish language, test its psychometric properties, and determine cutoff scores in a Turkish population with AI compared with observations in their healthy counterparts.

Synthesis, Anticancer Evaluation, Molecular Docking, and DFT Studies of Substituted Quinoline Derivatives.

Seven new quinoline derivatives with different functional groups at positions 2, 3, and 4 were synthesized and subsequently assessed for their biological activities. Four synthesized compounds exhibited significant cytotoxic effects against A549 and MCF7 cells. Compound 4f demonstrated IC values comparable to that of the standard drug doxorubicin and showed a similar selectivity profile, exhibiting low toxicity toward healthy NIH3T3 cells.

Intra-articular hexagonal boron nitride-hyaluronic acid composite hydrogels rebalance cytokine profiles and enhance extracellular matrix regeneration in a rabbit osteoarthritis model.

Objective: Osteoarthritis (OA) is a chronic, degenerative joint disease characterized by cartilage breakdown, inflammation, and progressive loss of joint function, leading to significant disability and reduced quality of life. Current treatment strategies, including pharmacological agents and intra-articular (IA) injections such as corticosteroids and hyaluronic acid (HA), provide symptomatic relief but fail to halt disease progression or promote cartilage regeneration. This study investigates the therapeutic potential of novel injectable hybrid hydrogels composed of hexagonal boron nitride (hBN) nanoparticles (NP) and nanosheets (NS) combined with HA.

Innovative utilization of organic cabin waste for hydrogen production: A case study at Antalya Airport.

This study suggested a way to produce valuable hydrogen from organic cabin waste collected at Antalya Airport, and it included energy and cost analyses of hydrogen production based on this method. In the proposed model, cabin waste is converted into biogas using anaerobic digestion technology, and hydrogen is produced from the biogas employing steam biogas reforming technology. Based on calculations, approximately 4126 m/day of biogas can be produced from 148 tonnes/day of organic cabin waste.

Reverse Transcription-qPCR-Based Investigation of Antiviral miRNAs in Medicinal Plants.

MicroRNAs (miRNAs) are endogenous regulators of gene expression that enable high adaptation to the living conditions of organisms. While plant antiviral miRNAs are effective in combating their viral pathogens, some plant miRNAs exhibit cross-kingdom interactions when targeting animal viruses. Current studies have reported that the miRNA contents of medicinal plants used in treating viral diseases are directly effective in combating the disease.

Global dominance of Haloquadratum walsbyi by a single genomovar with distinct gene content and viral cohorts from close relatives.

Haloquadratum walsbyi is generally the dominant species in hypersaline ecosystems at salt saturation conditions. Here, we followed the dynamics of its genomovars and associated viruses during recurrent evaporation-dilution disturbances of varying intensities at the mesocosm scale over 813 days. The diversity observed within a single mesocosm was also compared with that in a global-scale inventory of hypersaline environments of thalassohaline origin.

5(6)-Benzoyl-Substituted Benzimidazoles and Their Benzimidazolium Salts: Design, Synthesis, Characterization, Crystal Structure, and Some Metabolic Enzymes Inhibition Properties.

Herein, the synthesis of 1-alkyl-5(6)-benzoyl-substituted benzimidazoles and their 1,3-bisalkylbenzimidazolium halide salts are presented and evaluated for some metabolic enzyme inhibition. All compounds were characterized using various spectroscopic techniques. Single-crystal XRD analysis was performed to determine the molecular structure of two compounds.

Could Fingolimod Combined with Bevacizumab Be a New Hope in Glioblastoma Treatment?

Glioblastoma, classified as a grade IV astrocytoma, is an aggressive and malignant primary brain tumor with no known cure. Despite the implementation of standard medical and surgical treatment protocols, the disease often progresses with unsatisfactory outcomes. This study aimed to evaluate the cytotoxic, proapoptotic, and antimetastatic effects of anti-angiogenic monoclonal antibody bevacizumab combined with the sphingosine-1-phosphate receptor modulator fingolimod on rat glioma C6 cells.

Exploring Schiff Bases Derived from 2-hydroxybenzaldehyde as Potential Anticancer Agents: Synthesis, Characterization, Molecular Docking and in-vitro Evaluation.

Chemotherapy resistance is a major obstacle in cancer; thus, the development of new anticancer agents is being studied with great importance. Schiff bases containing an azomethine group have been widely used in various pharmaceutical applications. Here, five Schiff base derivatives of 2-hydroxybenzaldehyde (8S1-8S5) were synthesized and characterized.

Phytoestrogen Signal Pathways and Estrogen Signaling in Ovarian Cancer: A Narrative Review.

Ovarian cancer (OC) is the second most common gynecological cancer and the leading cause of death from gynecological malignancies. Ovarian cancer mortality rate ranks fifth among cancer-related deaths in Western societies. Hence, novel preventive and therapeutic ways are still in great demand to reduce the incidence and mortality rate of ovarian cancer.

The effect of pulmonary functions and respiratory muscle strength on sports performance in elite archers.

Background: The physical, physiological, and functional characteristics of archers affect target shooting performance. In our observational study, we aimed to examine the effect of pulmonary functions and respiratory muscle strength on sports performance in archers.

Methods: Our study included 46 (27 female, 19 male) professional archers registered in archery sports clubs in İstanbul.

Design, synthesis, and biological evaluation of novel vanillin-derived hydrazone compounds with antimicrobial, anticancer, and enzyme inhibition activities, along with molecular structure and drug-likeness assessment.

Vanillin-based compounds have recently gained attention in pharmaceutical chemistry as a novel class of organic molecules, demonstrating significant potential as drug candidates for various therapeutic applications. In this study, five novel bioactive Vanillin hydrazones (Van to Van) were synthesized and characterized. The synthesized compounds were evaluated for their anticancer activity against MDA-MB-231 breast cancer cells, acetylcholinesterase (AChE) inhibitory effects, antibacterial activity against Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, and Escherichia coli, as well as their biofilm inhibition against Pseudomonas aeruginosa.

Antibacterial Potential of a New Endiandric Acid From Beilschmiedia acuta (Lauraceae) Against Drug-resistant Bacteria.

A previously unidentified endiandric acid derivative named beilschmiedic acid P (1), together with eight (2-9) known compounds including four pentacyclic triterpenoids (3-6), one amide (2) and, three steroids (7-9) were isolated from Beilschmiedia acuta stem barks. Chromatographic techniques were used for these isolations while their characterization was based on their one-/two-dimensional nuclear magnetic resonance and mass spectrometry experiments. The antibacterial activity of the new compound (1) was tested via INT colourimetric assay against nine bacterial strains all expressing multidrug-resistant phenotypes including Klebsiella pneumoniae (KP55), Escherichia coli (AG102 and ATCC8739), Pseudomonas aeruginosa (PA124 and PA01), Enterobacter aerogenes (EA27 and ATCC13048) and Providencia stuartii (PS2636 and ATCC29916).

Production of boron nitride/titanium dioxide composite nanofibers sustainable electrospinning methods and their environmentally friendly photocatalytic and antibacterial applications.

Low-cost and environmentally friendly nanomaterials fabricated using sol-gel, electrospinning, hydrothermal and solvothermal methods are highly important for the removal of dyes (which are important water pollutants) from water sources and for reducing biological activity on the membrane surface of treatment facilities. In this study, boron nitride/titanium dioxide composite nanofibers (BTFs) were synthesized using an electrospinning method. The structural and optical properties of the BTFs were investigated using various analytical techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), ultraviolet-visible spectroscopy (UV-vis) and Fourier transform infrared spectroscopy (FTIR), and then, their capability for photocatalytic dye removal and antibacterial activity was studied.

The development of biopolyol/chitosan modified single-use disposable electrochemical biosensor and its application for the voltammetric monitoring of the biointeraction between ziram and double stranded DNA.

The main objective of the present study is to develop a novel and sustainable electrochemical biosensor for the monitoring of genotoxic effect of ziram. For this purpose, pencil graphite electrodes (PGEs) were modified with biopolyol obtained by liquefying olive pomace in polyhydric alcohols with an acid catalyst (BPL) and chitosan (CHIT), and the biointeraction between commercial form of ziram and DNA was performed at the surface of the CHIT/BPL-PGEs. Changes at the cathodic peak current (I) measured in 2.

Benefiting from Both Ethanol Oxidation and Bidentate Thiol Groups of DHLA Ligands under Photoirradiation for Synthesis of Au Nanoparticles With Their Catalytic and Peroxidase Like Activity.

In this work, we rationally synthesized quite stable gold nanoparticles (AuNPs) using dihydrolipoic acid (DHLA) and DHLA-aspartame (DHLA-Asptm) as both reducing and stabilizing agents in a mixture of water/ethanol at RT under photoirradiation in 10 min. The novelty of this work is that benefiting from both the oxidation of ethanol to ethanal and having the bidentate thiol groups of DHLA, stable DHLA@AuNPs and DHLA-Asptm@AuNPs were successfully and rapidly formed without additional reducing reagents. We systematically examined the formation of DHLA@AuNPs and DHLA-Asptm@AuNPs under different pH values and reaction temperatures.

Salicylaldehyde-derived Hydrazones: Synthesis, characterization, antibacterial activity, antioxidant and anti-inflammatory effects on LPS-induced RAW264.7 macrophage cells, drug-likeness properties, and molecular docking analysis.

The rising incidence of pathogenic microorganisms underscores the urgent need to develop innovative anti-inflammatory agents. This study aims to investigate the anti-inflammatory and antibacterial mechanisms of Schiff base (SB) derived from salicylaldehyde (SA) compounds in stimulated and unstimulated macrophage cell line (RAW264.7) cells.

Synthesis of Thiazole-methylsulfonyl Derivatives, X-ray Study, and Investigation of Their Carbonic Anhydrase Activities: and Potentials.

This study focused on the design, synthesis, chemical characterization, and potential inhibitory study of thiazole-methylsulfonyl derivatives against carbonic anhydrase enzymes. The synthesized compounds, with the characteristics of both the thiazole ring and methyl sulfonyl group, were synthesized through a two-step scheme, and their structures were confirmed through NMR spectroscopy and HRMS. Additionally, the structure of compound was elucidated by an X-ray study.

Boron Prevents Oral Acrylamide Damage in Bone Marrow and Hematologic Parameters of Wistar Rats.

The purpose of this study is to measure the effects of acrylamide (AA) on bone marrow and blood and the protective efficacy of boric acid (B) in rats. The animals were divided into five groups: control, B, low-dose B + AA, and high-dose B + AA. After the 15 th day of the experiment, their blood and bone marrow were harvested to be kept for hematological analyses.

A model for assessing the urban heat Island effect in urban regeneration areas: case of mamak and the north ankara.

Urban regeneration, which aims to provide increased sustainability in terms of higher quality urban environment and better urban livability, has been on the agenda in Türkiye. Ankara, the capital city, has long faced uncontrolled development of squatter areas due to rural-to-urban migration, resulting in critical structural problems, including low-quality constructions, poor infrastructure, and insufficient urban services. Urban regeneration has been presented as a solution to those problems.

Tuning the electronic properties of ZnO nanofilms strain-induced structural phase transformations and quantum confinement.

ZnO nanostructures have huge potential in a wide range of technologies, including photocatalysis, optoelectronics, and energy harvesting. ZnO commonly exhibits the wurtzite polymorphic phase (wz-ZnO) and is one of the few inorganic materials where nanoscale structural phase engineering has revealed alternative polymorphs. These structurally novel nanophases also have properties ( mechanical, electronic) that differ from those of wz-ZnO, and thus may pave the way to new applications.