Diagnostic and Therapeutic Strategies for Intraoperative and Postoperative Hypocalcemia in Pediatric Thyroidectomy Patients: A Single-Center Experience.

Background: The primary goals of surgical management in thyroid disorders are the treatment of malignancy, goiter, and thyrotoxicosis, while adhering to the principle of 'primum non nocere'. Hypocalcemia is among the most common complications, primarily resulting from inadvertent injury to the parathyroid glands.

Methods: A retrospective analysis of 2015-2023 records of Polish pediatric patients who underwent thyroid surgery.

Omics in NSAID-Exacerbated Respiratory Disease: Current Evidence From the Upper and Lower Airways.

Nonsteroidal anti-inflammatory drugs (NSAID)-exacerbated respiratory disease (N-ERD) is a mainly type 2 inflammatory condition that combines asthma, nasal polyps, and hypersensitivity to NSAIDs. Its pathogenesis involves both upper and lower airways, yet most studies to date have examined these compartments separately. It remains unclear whether the molecular mechanisms in the nose, sinuses, and lungs are distinct or overlapping-an important gap, given that clinical manifestations of N-ERD involve both sites.

Epigenome-wide DNA methylation profiling in aneurysmal subarachnoid hemorrhage and delayed ischemic neurologic deficit: a prospective observational study.

Background: The molecular mechanisms underlying aneurysmal subarachnoid hemorrhage (aSAH) and delayed ischemic neurologic deficit (DIND) remain poorly understood. We hereby present the study investigating epigenome-wide profile of DNA methylation in adults with aSAH and DIND.

Methods: A prospective observational epigenome-wide association study (EWAS) was conducted with DNA extracted from the peripheral whole blood of subjects with aSAH.

Transportation noise: its cardiovascular effects and their reversibility; a narrative review.

Background: Transportation noise seems to be inherent in modern urban living. However, many studies indicate that it can unfavorably affect human health, especially by influencing the cardiovascular outcome. The large number of people exposed to noise in the European Union becomes relevant to public health.

Clinical outcomes of intravascular lithotripsy according to the timing of stent failure: Insights from the COIL registry.

Background: Cumulative data has highlighted the efficacy of intra-vascular lithotripsy (IVL) in patients with stent failure (SF). However, it remains unclear whether the effectiveness of IVL, and subsequent clinical outcomes, are influenced by the timing of SF. We aimed to evaluate the outcomes of patients with SF undergoing IVL according to the age of index stent implantation.

Eustachian valve endocarditis in the context of right atrial embryonic remnants: A systematic review and meta-analysis.

Background: Eustachian valve endocarditis (EVE) is a rare right-sided infective endocarditis (RSIE) manifestation. This condition has scattered and limited clinical characteristics that require collection and systematization. This meta-analysis evaluates the predisposing factors, pathogens, and associated risk profiles in EVE cases.

Importance of an online educational platform for heart failure nurses in Poland: the results of the survey.

Background: Heart failure (HF) nurses play an important role in heart failure management. This study aimed to assess the knowledge of HF nurses in Poland regarding HF management.

Methods: 97 nurses from Poland provided their consent and completed an online questionnaire comprised of 20 questions.

Clinical characteristics and risk factors of metabolic dysfunction-associated steatotic liver disease in lean patients: results of the Polish Gallstone Surgery Registry.

Aim Of The Study: Data concerning the clinical manifestation and outcomes of lean metabolic dysfunction-associated steatotic liver disease (MASLD) are scarce and inconsistent. The aim of the study was to evaluate the clinical characteristics of MASLD and predictors of its occurrence.

Material And Methods: The study included patients from the Polish Gallstone Surgery Registry diagnosed with MASLD according to the current criteria.

Effectiveness and safety of nivolumab and ipilimumab in older adults with renal cell carcinoma: findings from a multicenter observational study in Poland.

Background: Nivolumab and ipilimumab (nivo+ipi) are recommended for treating metastatic clear cell renal cell carcinoma (mRCC), though their safety and efficacy in older adults remain uncertain. This study examines the outcomes of this regimen in Polish patients aged ≥65 years.

Methods: In this multicenter observational study, 138 patients with mRCC who received nivo+ipi between May 2022 and October 2024 were analyzed.

The Influence of Muscle Morphology on Oncological Outcomes: A Review.

Cancer is a common disease with significant impact on patients and society. Cancer and oncological treatment can negatively affect muscle, and muscle health impacts oncologic outcomes. This review studied the effect of different muscle parameters on oncologic outcomes.

Analysis of selected variables in body composition, upper limb strength, and resting energy expenditure among youth soccer players: insights based on field position.

Background: The study aimed to determine and compare selected variables of body composition, upper limb strength, and resting energy expenditure from the perspective of field position in youth soccer players.

Methods: The study group consisted of 189 boys aged 9 to 19 years ( = 14.7 ± 2.

In vitro repositioning therapy with olaparib, temozolomide and oxaliplatin in glioblastoma cell lines: U118, U87, U251, H4 and human fibroblasts.

Background: Central nervous system (CNS) tumors, including gliomas, are among the most aggressive cancers, with glioblastoma multiforme (GBM) being the most common and lethal. This study explores the potential of multidrug repositioning as a modern chemotherapy strategy for GBM cell lines. It combines the standard GBM chemotherapeutic temozolomide (TMZ) with olaparib (OLA) and oxaliplatin (OXA), both repurposed from other cancer types.

Evaluation of the morphology of anterior permanent mandibular teeth in a population of adolescents from Kraków aged 18-20 years on the basis of pantomography and volumetric tomography (CBCT) - a comparative analysis.

The use of cone beam computed tomography (CBCT) in endodontic diagnostics and treatment is gaining importance due to its ability to provide three-dimensional imaging of tooth structures and their surroundings. CBCT allows a precise assessment of the anatomy of the endodontic space, which is crucial in planning and performing effective root canal treatment. Traditional two-dimensional imaging techniques often prove insufficient in diagnosing the complex morphology of dental canals, increasing the risk of leaving areas untreated and potential treatment failure.

Exploring the Potential Benefits of Integrating Phenomenology into Everyday Healthcare Practice.

In contemporary medical practice, a reductionist focus on physical symptoms and biotechnological interventions often sidelines the relational and emotional dimensions of patient care. This paper explores the potential benefits of integrating phenomenological approaches into everyday healthcare practice. Drawing on the seminal works of Merleau-Ponty, Gallagher, Mazis, Benner, and Svenaeus, among others, the study illustrates how a phenomenological stance - characterized by a suspension of preconceptions and an embrace of "not-knowing" - can transform clinical encounters.

Atypical sites of origin of the main renal artery - narrative review.

Anatomical and clinical records were analyzed to identify cases of anomalous origins of the main renal artery. Instead of typically branching from the abdominal aorta at the vertebral level of L1-L2, the main renal artery can originate from the thoracic aorta, the inferior abdominal aorta (below the L2 vertebra), or from nearby arterial vessels such as the celiac trunk, superior mesenteric artery, inferior mesenteric artery, or common iliac artery.

Private Bariatric Surgery in Poland: Insights into Procedures, Distribution, and Standards of Care.

Introduction: Bariatric surgery is critical for management of pathological obesity. In Poland, there is a paucity of data regarding bariatric care in the private sector.

Aim: This study evaluates the characteristics of private bariatric centres in terms of performed procedure types, regional distribution, and the level of care in comparison to public facilities.

The analysis of the composition and antioxidant properties of freeze-dried chokeberry, strawberry, blackberry and selected raspberry fruits.

Unlabelled: Anthocyanins are a group of organic compounds believed to show anti-inflammatory, anti-proliferative, antioxidant, pro-apoptotic effects. For these reasons, anthocyanins may potentially be lied in the cancer chemoprevention as well as in providing a metabolic support during oncological treatment.

Objective: The aim of this study is to compare the antioxidant activity and analyze the content of bioactive substances in selected freeze-dried fruit species in order to determine the optimal source of anthocyanins for subsequent clinical trials involving patients undergoing treatment for colon cancer.

Jan (Johann, Johannes) Mikulicz-Radecki's cancer surgery in Krakow times.

Jan (Johann) Mikulicz-Radecki (1850-1905) was one of the most illustrious surgeons in the history of medicine, and eponyms in modern medicine bearing his name are still numerous. In this paper we present only a small part of his achievements, focusing on oncological aspects and narrowing our investigation to the period of 1882-1887, when Mikulicz was a professor in the Medical Faculty of Jagiellonian University, in Krakow.

The use of anterior segment optical coherence tomography (AS-OCT) in the imaging diagnostics of intracorneal foreign bodies.

Background: Eye injuries are a serious problem and may result in reduced visual acuity. The most common eye injuries include corneal damage, often involving the presence of a foreign body. OCT examination of the anterior segment - AS OCT - may be a valuable test in the diagnostics and follow-up of patients in whom the presence of a foreign body after eye trauma is suspected.

Association between cervical intraepithelial neoplasia progression and cervicovaginal microbiota status - narrative review.

In 2022, an estimated 660 000 women were diagnosed with cervical cancer worldwide and about 350 000 women died from the disease. Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections. However, only a small percentage of high-risk (HR) HPV infections progress to cervical precancer and cancer.

Dopa decarboxylase and angiotensin converting enzyme 2 immunoexpression in the gastrointestinal tract of control female Wistar rats - a pilot study.

Studies have shown important interactions between the local renin-angiotensin and monoaminergic systems in physiology and pathophysiology. Yet the understanding of such interactions in the gastrointestinal (GI) tract and GI-associated diseases is the least understood. Thus, the aim of our study was to characterize the expression pattern of DDC and ACE2 along the GI tract (duodenum, jejunum, ileum, and colon) of control female Wistar rats.