Solid-phase synthesis of polyunsaturated fatty acids facilitates precise structural investigation on FFAR1/4 agonist activities and the inhibition of neutrophil pseudopod formation.

Polyunsaturated fatty acids (PUFAs), fatty acids with multiple unsaturated carbon-carbon bonds, constitute a crucial class of lipids. While the vast diversity of PUFA species arises from their structural variations, most of them are poorly investigated due to their limited availability. Here, we utilize solid-phase synthesis of PUFAs, which we have recently developed, to construct a PUFA library.

Correction to "Preimplantation Genetic Testing for Aneuploidy and Chromosomal Structural Rearrangement: A Summary of a Nationwide Study by the Japan Society of Obstetrics and Gynecology".

[This corrects the article DOI: 10.1002/rmb2.12518.

Genetic Structure of (Peracarida: Cumacea): Effects of Topography and Historical Anoxic Events in the Sea of Japan.

Geohistorical events are among the most important factors determining population genetic structure. The Sea of Japan is an intriguing area because of its connection to neighboring seas via shallow straits (< 140 m deep) and the occurrence of deep-water anoxic events during glacial periods. Despite repeated anoxic events, species with low dispersal capabilities have been reported at depths deeper than the straits in both the Sea of Japan and the Pacific Ocean.

Development of a novel risk model to predict CRPC progression following IMRT: Implications for tailoring treatment intensity.

Objectives: To develop a novel risk score (RS) model to predict the probability of progression to castration-resistant prostate cancer (PCa) (CRPC) after intensity-modulated radiation therapy (IMRT) for patients with high- and very high-risk PCa according to the National Comprehensive Cancer Network (NCCN) risk classification, since accurate prediction of the clinical outcome of definitive radiation therapy for patients with high- and very high-risk PCa remains challenging due to its heterogeneity.

Materials And Methods: We conducted a retrospective review of 600 patients with high- and very high-risk PCa treated with IMRT at our institution. They were randomly divided into discovery (n = 300) and validation (n = 300) cohorts.

Corrigendum to: Impact of the COVID-19 outbreak on the field of hematopoietic cell transplantation in the Asia-Pacific region: APBMT Activity Survey 2020/2021 [Blood Cell Therapy. 2024; 7(4): 129-137. doi:10.31547/bct-2024-020].

[This corrects the article DOI: 10.31547/bct-2024-020.].

The effective and safe administration of Epcoritamab in relapsed CD19-CD5+ DLBCL following CAR-T therapy.

Background: Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the treatment landscape for relapsed or refractory non-Hodgkin lymphoma, achieving a 5-year overall survival rate of 40-50%. However, relapse remains a major challenge, especially due to CD19-negative clones. Epcoritamab, a bispecific antibody targeting CD20 and CD3, offers a potential solution for post-CAR-T relapse; however, clinical data in this setting remain limited, particularly in Japan.

Late-onset immune thrombocytopenia after unrelated cord blood transplantation for chronic myelomonocytic leukemia.

Several reports have been published on autoimmune hematologic complications, including immune thrombocytopenia (ITP), after cord blood transplantation (CBT). However, there have been no reports of late-onset ITP following CBT. A 51-year-old male with chronic myelomonocytic leukemia received unrelated CBT in 2012.

Prognostic impact of the acute reactiveness to intravenous administration of tolvaptan sodium phosphate in patients with acute decompensated heart failure.

Aims: Intravenous tolvaptan sodium phosphate (IV-tolvaptan) is a novel aquaretic agent for acute decompensated heart failure (ADHF). This study evaluated its short-term effects and prognostic implications in clinical practice.

Methods And Results: In this retrospective cohort of 169 consecutive ADHF patients receiving IV-tolvaptan for the first time (mean age 76.

Red Yeast Rice: A Review of the in vitro and in vivo Pharmacological Activities, Studies in Humans, and Case Reports.

Red yeast rice (RYR) is an Asian indigenous medicine that ferments grains using the Monascus fungi, specifically . Monacolins, pigments, phenols, sterols, and benzopyrans, such as the mycotoxin citrinin, were proven to be present in RYR, contributing to its numerous effects. This study aims to provide a thorough overview of the in vitro and in vivo pharmacological activities of red yeast rice, its studies in humans, and a summary of recent case reports.

Comparing mortality burdens attributable to ambient temperature and seasonal variation across major causes of death in Spain.

Background: Seasonal variation in mortality results from a combination of environmental, biological, and social factors, with ambient temperature recognized as a key contributor. However, comprehensive assessments disentangling temperature effects from other seasonal influences across a broad range of mortality causes remain limited. This study aimed to quantify and compare the mortality burden attributable to ambient temperature and broader seasonal variation across major causes of death in Spain.

Clinical and Healthcare Cost Characteristics of Severe Asthma Patients with Long-Term Control on Omalizumab: A Comparative Analysis with Patients Who Switched to Other Biologics.

Background And Purpose: Biologics are crucial for severe asthma treatment, but their high costs pose challenges. Omalizumab (OML) is dosed on the basis of patient-specific factors. The purpose of this study is to clarify the clinical characteristics of severe asthmatics who maintain long-term control on omalizumab including healthcare cost considerations.

Pancreatic Hemangioblastoma in a Patient with von Hippel-Lindau Disease: A Case Report.

Introduction: von Hippel-Lindau (VHL) disease is an autosomal dominant hereditary disorder characterized by the development of tumor-like lesions in multiple organs. While central nervous system hemangioblastomas, pancreatic neuroendocrine tumors, and pancreatic cysts are commonly associated with VHL disease, there have been few reported cases of pancreatic hemangioblastoma in patients with VHL disease.

Case Presentation: A male patient in his 30s had been diagnosed with VHL disease and had been followed for cerebellar and spinal hemangioblastomas, and renal cell carcinoma, for which he had undergone several tumor resections, radiation therapy, and a ventriculoperitoneal shunt.

Liver Transplantation Using a Whole-Liver Graft Donated from a Brain-Dead Donor Complicated with Rendu-Osler-Weber Syndrome: A Case Report.

Introduction: Osler-Weber-Rendu syndrome, or hereditary hemorrhagic telangiectasia (HHT), is a rare autosomal dominant genetic vascular disease characterized by arteriovenous malformations, vascular wall fragility, dilatation, and rupture of the vessels with hepatic symptoms. As HHT with hepatic symptoms is recognized as the primary etiology for liver transplantation, liver transplantation with liver grafts from donors affected by HHT is extremely rare. Herein, we report a successful liver transplantation in a patient with biliary atresia who received a whole-liver graft from a young brain-dead donor with HHT.

McKeown Esophagectomy for Esophageal Cancer Following Pancreaticoduodenectomy Using a Mesenteric Approach for Pancreatic Cancer: A Case Report.

Introduction: There are no reports of patients undergoing McKeown esophagectomy for esophageal cancer after undergoing pancreaticoduodenectomy for pancreatic cancer. We report the case of a patient who underwent subtotal esophagectomy and colon reconstruction after pancreaticoduodenectomy using the mesenteric approach.

Case Presentation: A 71-year-old male was diagnosed with advanced esophageal cancer.

Unique halogen-π association detected in single crystals of C-N atropisomeric -(2-halophenyl)quinolin-2-one derivatives and the thione analogue.

In single crystals of C-N atropisomeric -(2-halophenyl)quinolin-2-one and the thione analogue, a unique association based on a halogen-π interaction was detected. In racemic and optically pure -(2-bromo- or 2-chlorophenyl)quinolin-2-ones, homochiral layered polymers, which consist of ()- or ()-atropisomers, were formed through intermolecular halogen-π association. The halogen-π association in the racemates is due to a halogen bond (C-X···π) between a σ-hole on the halogen atom and a π-electron on the quinolinone benzene ring, while that in optically pure forms is caused by an n-π* interaction between a lone electron pair on the halogen atom and a π* orbital of the quinolinone.

The feature and significance of lower limb MRI in adult myositis patients with anti-NXP2 antibody: a retrospective cohort study in China.

Objective: This study aimed to describe the MRI features of lower limbs (thighs and calves) in patients with anti-NXP2 antibody positive myositis, and explore their relationship with clinical manifestations and prognosis.

Methods: Adult patients with anti-NXP2 antibody who underwent both thigh and calf MRI examinations simultaneously were enrolled between 2017 and 2023. The MRI features and medical records of patients were reviewed.

Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma.

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with limited treatment options and poor prognosis. Recent advances in cancer genomic analysis enable the identification of actionable gene alterations, opening new opportunities for personalized therapy. Among these, homologous recombination DNA repair (HRR) gene alterations are associated with distinct biological behavior, favorable prognosis, and increased sensitivity to platinum-based chemotherapy.

A modification of swimmer plot for overviewing the postoperative longitudinal course.

Background: Long-term follow-up is essential for assessing the efficacy of surgical methods in pediatric patients. However, cohort dropouts tend to increase over time. These losses to follow-up make it difficult to obtain reliable and convincing results.

Immunoregulatory Microenvironment in the Elderly Skin.

Previous studies have revealed that skin T cells accumulate and maintain immune responses in the elderly. However, we questioned why these functional T cells fail to recognize and eliminate malignant cells, making elderly skin more prone to developing malignant tumors. To address this question, we examined the overall skin microenvironment in aging using the Nanostring nCounter system and 10x Xenium digital spatial RNA sequencing.

Clinical Outcomes of a Multicenter Study Following Implantation of an Isofocal Optic IOL with Double C-Loop Haptics.

Purpose: To report clinical outcomes in patients implanted with an isofocal optic-design intraocular lens (IOL) with double C-loop haptics following cataract surgery.

Methods: This was a multicentre-prospective-study involving 108 eyes (54 subjects) implanted with the Isopure Serenity (BVI, Inc). IOL.

Left Ventricular Noncompaction Cardiomyopathy in Children: A Focus on Genetic and Molecular Mechanisms.

Left ventricular noncompaction (LVNC), also called noncompaction cardiomyopathy (NCM), is a myocardial disease that affects children and adults. Morphological features of LVNC include a noncompacted spongiform myocardium due to the presence of excessive trabeculations and deep recesses between prominent trabeculae. Incidence and prevalence rates of this disease remain contentious due to varying clinical phenotypes, ranging from an asymptomatic phenotype to fulminant heart failure, cardiac dysrhythmias, and sudden death.

Prevalence of Sleep-Disordered Breathing and Cheyne-Stokes Respiration in Patients With Atrial Fibrillation.

Background: Limited data are available regarding the prevalence of sleep-disordered breathing (SDB), particularly Cheyne-Stokes respiration (CSR), in patients with atrial fibrillation (AF) and left ventricular (LV) systolic dysfunction. Thus, this study aimed to investigate the prevalence of SDB and CSR, as well as the factors associated with these conditions, in patients with AF without LV systolic dysfunction.

Methods: Patients with paroxysmal and non-paroxysmal AF underwent echocardiography and cardiorespiratory polygraphy.

Updated Trends in Valvular Heart Disease-Related Heart Failure in G20-the Group of Twenty Countries: Insights From the Global Burden of Disease Study 2021.

Background: Valvular heart disease (VHD), including both non-rheumatic valvular heart disease (NRVHD) and rheumatic valvular heart disease (RVHD), is a major global health concern. Moreover, the progression of VHD to heart failure (HF) poses substantial clinical and public health challenges. In light of the global population aging, alongside increasing cardiovascular risk factors, and the additional strain imposed by the COVID-19 pandemic, a timely reassessment of the VHD-related HF burden is urgently needed.

Successful embolization of a large intrahepatic portosystemic shunt using the coil-in-plug technique: A case report assessed with four-dimensional flow magnetic resonance imaging.

Congenital intrahepatic portosystemic shunts are uncommon vascular anomalies that can lead to hyperammonemia and liver dysfunction. We report a 48-year-old woman with a large intrahepatic shunt presenting with elevated blood ammonia and progressive hepatic atrophy. She underwent percutaneous coil-in-plug embolization using an Amplatzer Vascular Plug II filled with coils.

Epithelioid glioblastoma mimicking metastatic brain tumor: A case report and literature review.

Epithelioid glioblastoma (eGBM) is a rare subtype of glioblastoma, generally associated with a poorer prognosis than conventional GBM despite maximum resection and standard chemoradiotherapy. Here, we report a case of a 78-year-old man who presented with left hemiplegia and a well-circumscribed right frontal lobe lesion on imaging, initially suspected to be a metastatic brain tumor. Surgical resection revealed a firm, clearly demarcated mass.