Deciphering the molecular landscape of acute myeloid leukemia initiation and relapse: a systems biology approach.

Acute Myeloid Leukemia (AML) patient-derived Mesenchymal Stem Cells (MSCs) behave differently than normal ones, creating a more protective environment for leukemia cells, making relapse harder to prevent. This study aimed to identify prognostic biomarkers and elucidate relevant biological pathways in AML by leveraging microarray data and advanced bioinformatics techniques. We retrieved the GSE122917 dataset from the NCBI Gene Expression Omnibus and performed differential expression analysis (DEA) within R Studio to identify differentially expressed genes (DEGs) among healthy donors, newly diagnosed AML patients, and relapsed AML patients.

4-aminopyridine exerts anxiolytic and pro-cognitive effects in mice model of medial prefrontal cortex ischemia.

Brain ischemia is a major global cause of disability, frequently leading to psychoneurological issues. This study investigates the effects of 4-aminopyridine (4-AP) on anxiety, cognitive impairment, and potential underlying mechanisms in a mouse model of medial prefrontal cortex (mPFC) ischemia. Mice with mPFC ischemia were treated with normal saline (NS) or different doses of 4-AP (250, 500, and 1000 µg/kg) for 14 consecutive days.

Teachers' experiences of supporting the mental health needs of refugee students in resource-poor settings: a qualitative study in Iran.

Exposure to traumatic events is common amongst children from refugee backgrounds. Given the restricted access of refugee children to formal specialist resources and disrupted parental support mechanisms in low- and middle-income countries (LMICs), teachers are increasingly expected to be the primary responders to the complex psychosocial needs of trauma-exposed refugee children. However, despite LMICs hosting over two-thirds of the world's refugee children, our current knowledge of how teachers respond to these needs is predominantly drawn from studies conducted in well-resourced, high-income countries, which fails to capture the unique experiences of teachers in inadequately resourced schools in LMICs.

Evolution of mass loss at Alamkouh Glacier in Iran using multi-temporal high-resolution DEMs between 2010 and 2023.

Small glaciers situated in high mountainous areas are experiencing notable declines, characterized by unprecedented rates of ice loss in recent years. This study investigates the recent changes in surface elevation and mass loss occurring between 2010 and 2023 within the Alamkouh Glacier over three subperiods, one of the biggest glaciers in Iran and the Middle East. These assessments are derived from a combination of high-resolution LiDAR data in 2010 (with a spatial resolution of 20 cm) and multi-temporal surveys conducted using unmanned aerial vehicles (UAVs) in 2018, 2020, and 2023 (with spatial resolutions varied from 10 to 20 cm).

Photodynamic inactivation of bacterial biofilms on absorbable collagen membranes using indocyanine green in aqueous and hydrogen peroxide solutions.

Microbial contamination of absorbable collagen membranes used in guided bone regeneration (GBR) may compromise healing outcomes. This study aimed to investigate whether the minimum inhibitory concentration (MIC) of hydrogen peroxide (HO) can improve the antibacterial effect of indocyanine green (ICG)-mediated antimicrobial photodynamic therapy (PDT) on absorbable collagen membranes while reducing the need for high HO concentrations. A laboratory-based model was developed using Streptococcus sanguinis and Staphylococcus aureus.

Environmentally friendly synthesis of carbon quantum dots (CQDs) to enhance photocatalytic activity for the photodegradation of various organic dyes and the evolution of hydrogen and oxygen.

This review delivers a focused and critical evaluation of recent progress in the green synthesis of carbon quantum dots (CQDs), with particular attention to state-of-the-art approaches utilizing renewable biomass as precursors. The main objective is to systematically examine innovative, environmentally friendly methods and clarify their direct influence on the core properties and photocatalytic performance of CQDs. The novelty of this review stems from its comprehensive comparison of green synthetic pathways, revealing how specific processes determine key structural, optical, and electronic attributes of the resulting CQDs.

Effect of pentoxifylline on serum levels and gene expression of inflammatory markers: a systematic review and meta-analysis of randomized controlled trials.

Background: Pentoxifylline (PTX), a methylxanthine derivative, has been recognized as a potential anti-inflammatory treatment across various conditions, yet its effects on inflammatory markers remain inconsistent. This systematic review/meta-analysis evaluated the impact of PTX on serum levels and gene expression of key inflammatory markers in randomized controlled trials (RCTs).

Methods: A systematic search was conducted in PubMed, Scopus, Embase, Web of Science, and ProQuest up to May 2025.

Antimicrobial activity of partially purified polysaccharide extract of Arthrospira platensis PCST5.

Arthrospira platensis (Spirulina) is one the highly valuable cyanobacteria in food and pharmaceutical industry. The intracellular and extracellular polysaccharide (PS) extracts of A. platensis have been exhibited different biological functions.

Thermotolerant yeasts promoting climate-resilient bioproduction.

The growing challenges posed by global warming and the demand for sustainable food and feed resources underscore the need for robust microbial platforms in bioprocessing. Thermotolerant yeasts have emerged as promising candidates due to their ability to thrive at elevated temperatures and other industrially relevant stresses. This review examines the industrial potential of thermotolerant yeasts in the context of climate change, emphasizing how their resilience can lead to more energy-efficient and cost-effective bioprocesses.

Prognostic models for radiation-induced complications after radiotherapy in head and neck cancer patients.

Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.

A Review on Biomarker-Enhanced Machine Learning for Early Diagnosis and Outcome Prediction in Ovarian Cancer Management.

Background: Ovarian cancer (OC) remains the most lethal gynecological malignancy, largely due to its late-stage diagnosis and nonspecific early symptoms. Advances in biomarker identification and machine learning offer promising avenues for improving early detection and prognosis. This review evaluates the role of biomarker-driven ML models in enhancing the early detection, risk stratification, and treatment planning of OC.

Localisation of an assessment tool for disease registry software.

Background: The success of disease registry systems (DRSs) depends on developing software that aligns with the registry's specific needs.

Objective: This study focuses on localising the Checklist with Items for Patient Registry sOftware Systems (CIPROS) to facilitate the DRS assessment.

Method: This applied and cross-sectional study was carried out in 2023 in six phases.

The Health Belief Model and Pediatric Fissure Sealant Therapy: Identifying Predictors of Parental Behavior-A Cross-Sectional Study.

Background And Aims: Dental caries in children remains a global health challenge. Fissure sealant therapy (FST) is an effective preventive measure, yet parental acceptance remains low. This study aimed to identify predictors of parental FST behavior for children aged 6-12 years in Bandar Abbas, Iran, using the health belief model (HBM).

Intraosseous Hemangioma of the Zygomatic Bone: A Rare Maxillofacial Case in a 57-Year-Old Woman.

Central hemangioma is one of the rare lesions of the jawbones, with a prevalence ranging between 0.5% and 1%. It more commonly occurs in the vertebral column and cranial bones, with rare occurrences in the jaws.

Utilizing biomaterials for laryngeal respiratory mucosal tissue repair in an animal model.

Introduction: The airway mucosa plays a crucial role in protection and various physiological functions. Current methods for restoring airway mucosa, such as myocutaneous flaps or split skin grafts, create a stratified squamous layer that lacks the cilia and mucus-secreting glands of the native columnar-lined airway. This study examines the application of various injectable biopolymers as active molecules for a potential approach to regenerating laryngeal epithelial tissue.

Efficient methylene blue elimination from water media by nanocomposite adsorbent-based carboxymethyl cellulose-grafted poly(acrylamide)/magnetic biochar decorated with ZIF-67.

A free radical polymerization approach was applied to synthesize different carboxymethyl cellulose-grafted poly(acrylamide) hydrogels (Hyd) composited with biochar, magnetic biochar, and magnetic biochar decorated with ZIF-67 to decontaminate methylene blue (MB) from water media. Biochar was obtained from walnut shells (WS) by a pyrolysis method, and magnetic biochar (WS/CoFeO) and biochar-decorated ZIF-67 (WS/CoFeO/ZIF-67) were prepared by chemical co-precipitation and hydrothermal methods, respectively. An increase in the amount of these particles by up to 10 wt% enhanced the removal performance.

Extraction and determination of esteric compounds in wound disinfectants.

This study focuses on developing an analytical method to efficiently extract and concentrate several adipate and phthalate plasticizers that can migrate from plastic packaging into various wound disinfectants. The study employed an approach that combined dispersive micro solid phase extraction with dispersive liquid-liquid microextraction using ZIF-4 as an adsorbent. The adsorbent was thoroughly characterized to understand its properties.

The impact of socioeconomic status on the burden of foodborne illnesses: a scoping review in the Middle East and North African region.

Background: Foodborne diseases remain a significant global health concern. Conversely, socioeconomic status represents a crucial predictor of diseases with increased morbidity and mortality rates. This scoping review (ScR) aims to provide an understanding of the impact of socioeconomic status on the occurrence of foodborne illnesses in the Middle East and North Africa (MENA) region.