Aurora B inhibition induces polyploidy and mitotic catastrophe in HER2-amplified breast cancer: Telomere shortening as a potential anticancer mechanism of AZD1152-HQPA.

Polyploidy, a conserved mechanism involved in normal development and tissue homeostasis, plays a paradoxical role in cancer by facilitating both tumor progression and therapeutic vulnerability. Although polyploidization may confer survival advantages to cancer cells, its controlled induction could represent an effective anticancer strategy. Aurora B kinase, a critical regulator of mitosis, plays a pivotal role in ensuring chromosomal integrity and preventing polyploidy.

The effect of aromatherapy massage with peppermint oil on functional impairments in patients with knee osteoarthritis.

Background: Knee osteoarthritis (KOA) is a prevalent degenerative joint disorder that significantly impairs physical function and daily activities. While conventional treatments focus on symptom management, complementary therapies such as aromatherapy massage have gained attention for their potential benefits.

Objective: This study evaluates the effects of peppermint oil aromatherapy massage on functional impairments in KOA patients.

Shaping resilient flood control system design through net present value assessments.

Designing sustainable Flood Control Systems (FCSs) requires considering both the resiliency of the system and the long-term viability of investments. In this regard, our research aimed at integrating concepts of hydrological resiliency and cost-benefit analysis to design the most effective flood control network. To do so, first, the Storm Water Management Model (SWMM) was developed for simulating flood condition.

Curcumin Liposomal Nanoparticles Provide Superior Neuroprotection by Attenuating Neuropathic Pain, Neuroinflammation, and Anxiety in Chronic Sciatic Nerve Injury in rats.

Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability.

Early-Start vs. Late-Start Icodextrin for Children Receiving Chronic Peritoneal Dialysis: Findings from the International Pediatric Peritoneal Dialysis Network.

Background: Experience with icodextrin use in children on long-term peritoneal dialysis is limited. We describe international icodextrin prescription practices and their impact on clinical outcomes: ultrafiltration, blood pressure control, residual kidney function (RKF), technique and patient survival.

Methods: We included patients under 21 years enrolled in the International Pediatric Peritoneal Dialysis Network (IPPN) between 2007 and 2024, on automated PD with a daytime dwell.

engineering of acetylesterase for enhanced thermal stability and efficiency.

Acetylesterase, produced by , plays a crucial role in deacetylating hemicellulose during pulp production. Thermostable variants of this enzyme, although rare, can significantly enhance industrial efficiency by retaining activity at high temperatures. This research aims to design a thermostable variant of acetylesterase from (EC 3.

Melatonin Ameliorates Isoproterenol-Induced Cardiac Fibrosis by Suppressing BIP/PERK/CHOP Signaling Pathways; Insights from In Silico and In vivo Studies.

In cardiovascular research, melatonin has shown promise in exhibiting antifibrotic properties and modulating endoplasmic reticulum (ER) stress. However, the exact mechanism by which it influences myocardial fibrosis has not been fully clarified. Therefore, this research aimed to investigate the inhibitory effect of melatonin on the progression of myocardial fibrosis through a mechanism involving the BIP/PERK/CHOP signaling pathway, both in silico and in vivo experimental models.

Natural and synthetic antimicrobial peptides against anaerobic bacteria: A review of activities and mechanisms of action.

Anaerobic bacteria cause a wide range of infections, varying from mild to severe, whether localized, implant-associated, or invasive, often leading to high morbidity and mortality. These infections are challenging to manage due to antimicrobial resistance against common antibiotics such as carbapenems and nitroimidazoles. The empirical use of antibiotics has contributed to the emergence of resistant organisms, making the identification and development of new antibiotics increasingly difficult.

NPY-functionalized niosomes for targeted delivery of margatoxin in breast cancer therapy.

Neuropeptide Y (NPY) and the voltage-gated potassium channel Kv1.3 are closely associated with breast cancer progression and apoptosis regulation, respectively. NPY receptors (NPYRs), which are overexpressed in breast tumors, contribute to tumor growth, migration, and angiogenesis.

The effect of magnetic fields on the antimicrobial and antioxidant properties of toothpaste produced by phycoerythrin and Oliveria decumbens Vent. oil.

Streptococcus mutans, a key cause of dental caries, is not treated by conventional toothpaste, brushing, flossing, or antiseptic mouthwashes. This necessitates the development of enriched toothpaste. Cyanobacteria-derived phycoerythrin (PE) has antioxidant and antibacterial properties.

National Update on Healthcare-Associated Infections in Iran for 2023-Based on the Iranian Nosocomial Infections Surveillance (INIS) System.

Background: Healthcare-associated infections (HCAIs) pose a serious threat to healthcare systems. Accurately determining the incidence of HCAIs is crucial for planning and implementing efficient interventions, as they are associated with a wide range of challenges. The objective of this study was to assess and update the incidence rates of HCAIs in Iran in 2023, using data from the Iranian Nosocomial Infection Surveillance (INIS) system, a nationwide hospital-based surveillance program.

Targeting the tumor microenvironment in colorectal cancer: the effect of Rapamycin on angiogenesis, apoptosis, and STAT5A/TORC1 signaling.

Background: Colorectal cancer (CRC) remains one of the leading causes of cancer-related mortality worldwide. The tumor microenvironment (TME), particularly the interactions between endothelial cells and cancer-associated fibroblasts (CAFs), plays a pivotal role in promoting tumor growth, angiogenesis, oxidative stress, and therapy resistance. The HUVEC-fibroblast co-culture model closely mimics stromal-endothelial interactions observed in CRC, enabling mechanistic insights not achievable in monocultures.

Exploring the therapeutic potential of L-arginine in chronic anal fissure management: a comprehensive review.

Anal fissure causes pain and bleeding during or after bowel movements, significantly impacting individuals' quality of life. Current treatments aim to interrupt this cycle but have associated risks and limitations. The emergence of arginine, crucial for protein creation and nitric oxide (NO) production, presents an intriguing therapeutic avenue by the impact on reducing anal sphincter pressure and enhancing anoderm blood flow, due to its roles in vasodilation, anti-inflammatory responses, and collagen synthesis, which can promote wound healing and highlighting its potential as an alternative therapy.

Hookah Use and Knowledge of Harmful Substances among University Students in Iran.

Hookah use is a growing global health concern, particularly among young adults, with significant misconceptions about its safety. This study aimed to investigate the prevalence of hookah use and its association with knowledge of harmful substances and future susceptibility among university students in Iran. A cross-sectional study was conducted among 561 undergraduate students from Golestan University of Medical Sciences in Iran between April and June 2024.

The Effect of the Nurse's Compassionate Speech on the Pain Associated With Intravenous Catheter Insertion in Premature Neonates.

Background: Venipuncture is a common and painful procedure in the neonatal intensive care unit (NICU), Thus, there is a necessity for cost-effective, safe, and nonpharmacological interventions to alleviate pain associated with frequent and painful procedures in infants.

Objective: This study aimed to investigate the effect of compassionate speech by nurses on the pain caused by venipuncture in premature infants.

Method: This quasi-experimental study was conducted on 65 premature infants admitted to the neonatal intensive care units of the Imam Reza and Qaem hospitals in Mashhad, Iran.

Sex-specific behavioral impairments and neuronal alterations in Wistar rats following repeated sevoflurane exposure during developmental stages.

Objectives: This study aimed to investigate the effects of repeated exposure to sevoflurane as an anesthetic agent during various developmental stages, namely neonatal, preadolescent, and adult, on behavioral, synaptic, and neuronal plasticity in male and female Wistar rats.

Methods: Rats were exposed to sevoflurane during three developmental stages: neonatal (PN7), pre-adolescence (PN28), and adulthood (PN90). Behavioral performance was evaluated with the Morris Water Maze.

Dynamic systems modeling for quality improvement in reducing neonatal mortality: evidence from Kerman and Bam, Iran.

Purpose: Neonatal mortality is a significant global health issue, particularly in low- and middle-income countries. This study aims to identify and understand the factors contributing to high neonatal mortality rates in the cities of Kerman and Bam, Iran, to develop effective strategies for improvement.

Design/methodology/approach: We employed systems dynamics to develop Causal Loop Diagrams that capture qualitative interactions among determinants of neonatal mortality.

Randomized Clinical Trial on the Efficacy of Oral Tranexamic Acid Versus Topical Tranexamic Acid in Treatment of Melasma.

Background: Melasma is a prevalent skin condition that primarily affects females of reproductive age. Despite the various available treatments, managing melasma is challenging due to frequent relapses and partial responses. Tranexamic acid (TXA) has gained attention as a potential treatment because of its antifibrinolytic and anti-melanogenic properties.

Composite Scaffolds of Decellularized Placenta/PRP Enhance the Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells Into Insulin-Producing Cells In Vitro.

In the current in vitro experiment, we fabricated and characterized placenta/platelet-rich plasma (PL/Pt) composite scaffolds and evaluated their effect on differentiating adipose stem cells (ASCs) into insulin-producing cells (IPCs) in vitro. The human placenta (PL) was decellularized (dPL), characterized, and digested in pepsin. PRP was extracted using a two-step centrifugation process and then freeze-dried.

Time perception deficits in attention deficit hyperactivity disorder (ADHD): The role of working memory, attention and reaction time.

Objective: Attention deficit hyperactivity disorder (ADHD) is linked to time perception deficits, with theories such as Scalar Expectancy Theory (SET) and Dynamic Attending Theory (DAT) offering different explanations. SET suggests time perception relies on a pacemaker-counter system influenced by working memory, whereas DAT highlights the role of attention in modulating time perception. This study examines the impact of attention, working memory, and motor response on time perception in children with ADHD.

Variation of Morphology and Optical Properties of PVD Coated Titanium Dioxide Layers at Different Oxygen Flows.

Titanium dioxide (TiO) thin films were deposited on glass substrates under HV conditions at room temperature by the physical vapor deposition method. Produced titanium thin films were post-annealed at 573 K at different oxygen flows (0, 9 and 23 cm/s). The influence of different oxygen flows on nano-structure, crystallography, and optical parameters of TiO films was investigated by XRD, AFM, and spectrophotometer in the UV-VIS wavelength range.

Studying the relationship between allergo-inflammation and left atrium and pulmonary vein pathological changes in allergic asthma.

Allergic asthma is an inflammatory airway disease influenced by genetic and environmental factors and orchestrated by imbalance between T helper 1 cell (Th1) and two immune responses. Inflammation contributes to pathological changes and remodeling in tissues such as the vascular, lung, heart, and beds. The purpose for this study was to evaluate the effects of allergic asthma on heart pathology and remodeling.