Digital health and Buddhist network philosophy.

Heated online communication reveals global challenges in the digital age, often fuelled by collective outrage. This article investigates how Buddhist network perspectives, paralleling digital reality, can inform mental health. Avatamsaka philosophy provides practical ways to navigate web complexities, suggesting that individual actions ripple across society.

A cross-scale analysis for the determinants of bonding dynamics on the distributions of rolling velocities of cells in microvessels.

The interplay between subcellular adhesion dynamics and cellular-scale deformations under shear flow drives key physiological and pathological processes. While both bond kinetics and fluid-cell interactions have been extensively studied in rolling adhesion, how bond characteristics quantitatively determine cellular velocity distributions remains unclear. In this study, we systematically investigate how force-free bond kinetics and intrinsic mechanical properties govern rolling adhesion dynamics, using macroscopic velocity distributions as a reference.

Shigella type-III secretion system effectors counteract the induction of host inflammation and cell death.

Many enteric bacterial pathogens deliver virulence effectors to counteract host innate immune responses, such as inflammation and cell death, and colonize the intestinal epithelium. However, host cells recognize the disruption of their innate immune signaling by bacterial effectors and induce alternative immune responses, collectively termed "effector-triggered immunity", to clear bacterial pathogens. Here, we describe a mechanism of cell death induction via effector-triggered immunity and the bacterial countermeasures of the pathogen Shigella flexneri.

Late fluid flow in a primitive asteroid revealed by Lu-Hf isotopes in Ryugu.

Carbonaceous asteroids are the source of the most primitive meteorites and represent leftover planetesimals that formed from ice and dust in the outer Solar System and may have delivered volatiles to the terrestrial planets. Understanding the aqueous activity of asteroids is key to deciphering their thermal, chemical and orbital evolution, with implications for the origin of water on the terrestrial planets. Analyses of the objects, in particular pristine samples returned from asteroid Ryugu, have provided detailed information on fluid-rock interactions within a few million years after parent-body formation.

Space-Time Optical Hopfion Crystals.

Hopfions-higher-dimensional topological quasiparticles with sophisticated 3D knotted spin textures discovered in condensed matter and photonic systems-show promise in high-density data storage and transfer. Here, we present crystalline structures of hopfions lying in space-time constructed by spatiotemporally structured light. Practical methodologies using bichromatic structured light beams or dipole arrays to assemble 1D and higher dimensional hopfion lattices are proposed, and a technique for tailoring topological orders is elucidated.

Real-Time Continuous Tongue Pressure Measurement With Mouthguard-Type Pressure-Sensing Device.

Objective: It is well-established that occlusion and dental arch form are related to the morphology and function of the oral soft tissues. Oral soft tissue dynamic assessment is important for elucidating the causes of malocclusion and developing effective treatment methods. We previously developed a small mouthguard-type sensing device for measuring oral soft tissue pressure; however, its continuous measurement performance had not been thoroughly evaluated.

A Rare Case of Immune-related Adverse Events Localized to the Small Intestine.

Enterocolitis is a common gastrointestinal manifestation of immune-related adverse events (irAEs); however, only a few studies have reported on irAE enteritis with localized active inflammation in the small intestine. Here, we report the case of a 74-year-old man who developed diarrhea, abdominal pain, and oral intake difficulty and was subsequently hospitalized after receiving atezolizumab for pulmonary adenocarcinoma. Computed tomography and enterocolonoscopy revealed active inflammation in the small intestine but not in the colon, leading to the final diagnosis of irAE enteritis.

Electroactive ceramic biomaterials on the principle of bone piezoelectricity towards advanced bone engineering.

This review concentrates on the electroactive ceramic biointerfaces inspired by bone piezoelectricity for advanced ceramic biomaterials. Bone generates electrical potentials through the piezoelectric properties of collagen fibrils and apatite minerals under mechanical loading. These electrical signals influence osteoconductivity and regenerative capacity by osteogenic cells.

Adrenal lipoma formation via PI(3,4,5)P/AKT-dependent transdifferentiation of adrenocortical cells into adipocytes.

Adrenal lipomas are benign tumors containing ectopic adipose tissue in the adrenal gland, an organ that normally lacks both adipocytes and their progenitors. The origin of this ectopic fat remains enigmatic, and the absence of a genetic animal model has hindered its investigation. Phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P], a key signaling lipid that regulates cellular growth and differentiation, is tightly regulated by the lipid phosphatases PTEN (phosphatase and tensin homolog) and SHIP2 (SH2-containing inositol phosphatase 2).

Association between transitional care in acute care hospitals and ambulatory care sensitive condition-related readmission.

Background: Little is known about how ambulatory care sensitive condition (ACSC)-related readmissions can be reduced in acute care settings.

Objective: This study examined the association between transitional care for hospitalised older patients with ACSC and ACSC-related readmissions.

Methods: This retrospective observational cohort study included patients aged 65 years and older admitted with ACSC as the primary diagnosis from 1 April 2022 to 31 January 2023, using linked data from the Diagnosis Procedure Combination and the medical functions of the hospital beds database.

Tunable cell separation using a thermo-responsive deterministic lateral displacement device.

Tunability in isolating target cells of varying sizes from complex heterogeneous samples is essential for biomedical research and diagnostics. However, conventional deterministic lateral displacement (DLD) systems lack flexibility due to their fixed critical diameters (). Here, we present a thermo-responsive DLD micropillar array that enables tunable cell separation by dynamically modulating through temperature control.

Short- and Long-Term Outcomes of Open, Laparoscopic, and Robot-Assisted Surgery for Rectal Cancer.

Background: Robot-assisted surgery has short-term benefits in rectal cancer surgery; however, its long-term advantages remain unclear. This study compared short- and long-term outcomes of open, laparoscopic, and robot-assisted rectal cancer surgeries using large-scale, database-driven evidence.

Methods: Patients (28 711) diagnosed with clinical stages I-III rectal cancer who underwent rectal resection and were registered in the Japanese Medical Data Vision Co.

Enhancing Accuracy of Newborn Screening for 21OHD: Strategic Use of 21-Deoxycortisol in a Large-Scale Tokyo Cohort.

Context: Newborn screening (NBS) for 21-hydroxylase deficiency (21OHD) has historically shown high false positive (FP) rates, especially in low birth weight (LBW) infants. In 2022, we proposed a second-tier liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based algorithm to improve screening specificity; however, its real-world performance remains unassessed prospectively.

Objective: To prospectively evaluate our LC-MS/MS-based screening algorithm for 21OHD and develop a refined version addressing newly identified clinical limitations.

Symptomatic visceral arterial thrombosis in a patient with polycythemia vera successfully treated with mesenteric revascularization: A case report.

Rationale: Polycythemia vera (PV) is a type of myeloproliferative disorder, and thrombosis is one of its important complications. Arterial thrombosis commonly occurs in the coronary and cerebral arteries; however, reports of thrombosis in other arteries are limited, and it is even rarer in visceral arteries.

Patient Concerns: A 50-year-old woman with PV presented with anorexia and epigastric pain.

Development of a predictive score for prolonged pelvic operation time in robot-assisted low anterior resection: a single-center, retrospective study in Japan.

Background: Robot-assisted surgery has been widely adopted for the treatment of rectal cancer. Preoperative identification of difficult cases is essential, particularly for surgical training and operating room management. This study aimed to identify preoperative risk factors and develop a predictive scoring system for prolonged pelvic operation time in robot-assisted low anterior resection.

An electrochemiluminescence device powered by streaming potential for the detection of amines in flowing solution.

The research and implementation of portable and low-cost analytical devices that possess high reproducibility and ease of operation is still a challenging task, and a growing field of importance, within the analytical research. Herein, we report the concept, design and optimization of a microfluidic device based on electrochemiluminescence (ECL) detection that can be potentially operated without electricity for analytical purposes. The device functions exploiting the concept of streaming potential-driven bipolar electrochemistry, where a potential difference, generated from the flow of an electrolyte through a microchannel under the influence of a pressure gradient, is the driving force for redox reactions.

Timing of surgery and outcomes in patients with congenital pulmonary airway malformation: a national inpatient database study.

Purpose: The timing of elective surgery for asymptomatic congenital pulmonary airway malformation (CPAM) at birth remains controversial. We aimed to describe characteristics and outcomes of patients who underwent surgery for CPAM.

Methods: We retrospectively identified patients aged < 18 years who were hospitalized for CPAM during the neonatal period and underwent surgery between July 2010 and March 2022 using the Diagnosis Procedure Combination database in Japan.

Flatness-based control for generalized synchronization of chaotic systems with large dissipation and dimension mismatch.

A flat control law is based on the structural analysis of a controlled system, allowing optimal placement of sensors and actuators. Once designed, any desired dynamics can be imposed onto the system. When the target dynamics comes from a system structurally different from the controlled one, generalized synchronization can be achieved, provided the control gain is sufficiently large.

Peginterferon-alpha-2a add-on to treatment with siRNA JNJ-73763989 in virologically suppressed chronic hepatitis B: The phase II PENGUIN study.

Background & Aims: Previous studies showed that combination treatment with short interfering RNA JNJ-73763989 (JNJ-3989) ± capsid assembly modulator bersacapavir (JNJ-56136379) and nucleos(t)ide analogs (NAs) was well tolerated by patients with chronic HBV (CHB), with JNJ-3989 dose-dependent reductions in viral markers, including HBsAg. The open-label, single-arm phase IIa PENGUIN study (NCT04667104) evaluated this regimen plus pegylated interferon alpha-2a (PegIFN-α2a) in patients with virologically suppressed CHB.

Methods: Patients who were either HBeAg-positive or -negative virologically suppressed and taking NAs were included; all received JNJ-3989 ± bersacapavir for 24 weeks (some either did not start or discontinued bersacapavir as a result of protocol amendment) with PegIFN-α2a added during the final 12 weeks of treatment.

Measurement-Based Analysis of a Novel Method for Orthodontic Mandibular Molar Protraction Using an Improved Superelastic Ni-Ti Alloy Wire.

Purpose Improved superelastic nickel-titanium (Ni-Ti) alloy wires (ISWs) can be used not only for aligning but also for closing the extraction space. The objective of this study was to measure and compare the force and moment generated during mandibular molar protraction using an ISW combined with either short or long hooks under simulated crowded dentition conditions. Materials and methods Assuming crowded dentition following mandibular first premolar extraction, we designed a three-tooth model simulating the canine, the second premolar, and the first molar.

ECM-Preserving Decellularization of Dermis via Subtle Cell Membrane Disruption Induced by Subcritical Dimethyl Ether.

Decellularized tissues are used as biomaterials for transplantation. Many decellularized tissues in clinical applications are prepared using surfactants; however, we have developed a new decellularization method that uses subcritical dimethyl ether (DME) instead of surfactants. Subcritical DME perfusion is usually used for lipid extraction; therefore, by perfusing tissues with subcritical DME, phospholipid cell membranes may be destroyed.

Quality and representativeness of research online with Yahoo! Crowdsourcing.

Introduction: Conducting research online has become common in human participant research and notably in the field of human-computer interaction (HCI). Many researchers have used English-language and Western participant pool and recruitment platforms like Amazon Mechanical Turk and Prolific, with panel quality and representativeness known to vary greatly. Less is known about non-English, non-Western options.

Thoracic Duct Embolization via Retrograde Cannulation of a Leaking Stump through the Thoracic Cavity.

Thoracic duct embolization has emerged as an alternative treatment for refractory chylothorax, in addition to thoracic duct ligation. Thoracic duct embolization is typically performed via direct puncture of the cisterna chyli and cannulation of the thoracic duct, or via a retrograde approach to the thoracic duct through the venous angle. The former requires a long puncture through abdominal organs; the latter has anatomical limitations depending on the case.