A Switchable Fluorescent Sensor Based on NH-MIL-53(Al) for Detection of Ascorbic Acid in Fresh Fruits.

The detection of ascorbic acid (AA) in foods is important for ensuring nutritional quality and monitoring the stability and shelf life of food products. In the present work, the amino-based metal-organic framework NH-MIL-53(Al) was used for highly sensitive and selective detection of AA. The NH-MIL-53(Al) nanocrystals were synthesized using a facile solvothermal method and characterized using different techniques.

A Microwire Embedded with a NiSe/MoSe Microsupercapacitor with Photoinduced Ultrahigh-Energy Amplification.

Microsupercapacitors (MSCs) have emerged as promising miniaturized energy-storage devices for self-powered electronics. However, their practical adoption is hindered by insufficient energy density, poor stability, and short lifespan, necessitating solutions for improved practicability. Herein, we report a novel microwire embedded NiSe/MoSe (NMS) heterostructure MSC that addresses these challenges through photoenhanced energy storage.

Upconversion enabled innovation: Transfer of lab sensor to smartphone based field device.

WHO alerted that over 200 diseases are caused by the presence of food borne contaminants that pose a long-term health effect. Existing techniques suffer with the sophisticated instrumentation and skilled labour requirement. Nanomaterials based fluorescence sensors for detection of food contaminants have revolutionised the food sector by delivering high throughput assay.

A combination of systemic mannitol and mannitol modified polyester nanoparticles for caveolae-mediated gene delivery to the brain.

Overcoming the blood-brain barrier (BBB) remains a significant challenge for nucleic acid delivery to the brain. We have explored a combination of mannitol-modified poly (β-amino ester) (PBAE) nanoparticles and systemic mannitol injection for crossing the BBB. We incorporated mannitol in the PBAE polymer for caveolae targeting and selected monomers that may help avoid delivery to the liver.

Fluorescent aptasensor for detection of Salmonella typhimurium using boric acid-functionalized terbium metal-organic framework and magnetic nanoparticles.

A fluorescent detection platform was designed using boric acid-functionalized terbium metal-organic framework (BA-Tb-MOF) and carboxyl-modified magnetic nanoparticles (MNPs) to identify Salmonella typhimurium (S. typhimurium) bacteria. Firstly, carboxyl-modified FeOMNPs were coated with specific aptamer (Apt-MNPs) as the capture probe for S.

Room Temperature Single-Component Organic Multiferroics with Large Magnetoelectric Coupling: Proficient Approach for Stray-Magnetic Field Harvesting.

Magnetoelectric materials are highly desirable for technological applications due to their ability to produce electricity under a magnetic field. Among the various types of magnetoelectric materials studied, their organic counterparts provide an opportunity to develop solution-processable, flexible, lightweight, and wearable electronic devices. However, there is a rare choice of solution-processable, flexible, lightweight magnetoelectric materials which has tremendous technological interest.

Green synthesis of magnesium oxide nanoparticles using Hyphaene thebaica extract and their photocatalytic activities.

Magnesium oxide nanoparticles (MgO NPs) represent an interesting inorganic material widely utilized across various fields including sensing, antimicrobial applications, optical coatings, water purification, fuel additives, absorbents, and catalysis, owing to their exceptional broad energy band gap, surface affinity, and strong chemical and thermal durability. In this investigation, MgO NPs were successfully synthesized through a green approach employing fruit extract from the gingerbread tree (Hyphaene thebaica). Analysis via scanning electron microscopy (SEM) and transmission electron microscopy (TEM) confirmed their agglomerated quasi-spherical shape with a size range of 20-60 nm.

Biogenic synthesis of nickel cobaltite nanoparticles via a green route for enhancing the photocatalytic and electrochemical performances.

Green synthesis aligns with the global demand for eco-friendly and sustainable technologies, reducing the dependency on harmful chemicals and high-energy processes typically used in conventional synthesis techniques. This study highlights a novel green synthesis route for nickel cobaltite nanoparticles (NiCOO NPs) utilizing Hyphaene thebaica extract as a natural reducing and stabilizing agent. The synthesized NiCOO NPs, with sizes ranging from 20 to 30 nm, exhibited uniform diamond-like structures as confirmed by SEM and TEM imaging.

Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-β Accumulation in Alzheimer's Disease.

Amyloid-β (Aβ) peptide aggregation in the brain is a key factor in Alzheimer's disease. However, direct inhibition of β-secretase or γ-secretase proves ineffective in reducing Aβ accumulation and improving cognition in Alzheimer's. Recent findings suggest that inhibiting gamma-secretase activating protein (GSAP) can decrease Aβ generation without affecting crucial γ-secretase substrates.

Silver Nanoparticle-Embedded Carbon Nitride: Antifungal Activity on and Toxicity toward Animal Cells.

The development of engineered nanomaterials has been considered a promising strategy to control oral infections. In this study, silver-embedded carbon nitrides (Ag@g-CN) were synthesized and tested against , investigating their antifungal action and biocompatibility in animal cells. Ag@g-CN was synthesized by a simple one-pot thermal polymerization technique and characterized by various analytical techniques.

Emerging biosensors in Phenylketonuria.

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder resulting from deficient phenylalanine hydroxylase (PAH) enzyme activity, leading to impaired phenylalanine (Phe) metabolism. This condition can lead to intellectual disability, epilepsy, and behavioural issues. Treatment typically involves strict dietary restrictions on natural protein intake, supplemented with chemically manufactured protein substitutes containing amino acids other than Phe.

Harnessing potential of avian eggshell membrane derived collagen hydrolysate for bone tissue regeneration.

Background: Natural bone grafts are the highly preferred materials for restoring the lost bone, while being constrained of donor availability and risk of disease transmission. As a result, tissue engineering is emerging as an efficacious and competitive technique for bone repair. Bone tissue engineering (TE) scaffolds to support bone regeneration and devoid of aforesaid limitations are being vastly explored and among these the avian eggshell membrane has drawn attention for TE owing to its low immunogenicity, similarity with the extracellular matrix, and easy availability.

Eye Drop with Fas-Blocking Peptide Attenuates Age-Related Macular Degeneration.

Age-related macular degeneration (AMD), characterized by macular retinal degeneration, poses a significant health concern due to the lack of effective treatments for prevalent dry AMD. The progression of AMD is closely linked to reactive oxygen species and Fas signaling, emphasizing the need for targeted interventions. In this study, we utilized a NaIO-induced retinal degeneration mouse model to assess the efficacy of Fas-blocking peptide (FBP).

Er-activated BaVO upconversion nanosheets for dual-mode temperature sensing.

So far, there has been substantial research on non-contact luminescence thermometry approaches that rely on luminescence intensity ratio (LIR) technology. However, there is limited availability of phosphors doped with Er ions that exhibit on-par luminescence and high sensitivity. In this work, samples of BaVO:Er were synthesized using a sol-gel method aided by citric acid.

Intranasal Delivery of Anti-Apoptotic siRNA Complexed with Fas-Signaling Blocking Peptides Attenuates Cellular Apoptosis in Brain Ischemia.

Ischemic stroke-induced neuronal cell death leads to the permanent impairment of brain function. The Fas-mediating extrinsic apoptosis pathway and the cytochrome c-mediating intrinsic apoptosis pathway are two major molecular mechanisms contributing to neuronal injury in ischemic stroke. In this study, we employed a Fas-blocking peptide (FBP) coupled with a positively charged nona-arginine peptide (9R) to form a complex with negatively charged siRNA targeting Bax (FBP9R/siBax).

Sugar alcohol-modified polyester nanoparticles for gene delivery selective caveolae-mediated endocytosis.

Nucleic acid-based drugs are changing the scope of emerging medicine in preventing and treating diseases. Nanoparticle systems based on lipids and polymers developed to navigate tissue-level and cellular-level barriers are now emerging as vector systems that can be translated to clinical settings. A class of polymers, poly(β-amino esters) (PBAEs) known for their chemical flexibility and biodegradability, has been explored for gene delivery.

Systemic Treatment with Fas-Blocking Peptide Attenuates Apoptosis in Brain Ischemia.

Apoptosis plays a crucial role in neuronal injury, with substantial evidence implicating Fas-mediated cell death as a key factor in ischemic strokes. To address this, inhibition of Fas-signaling has emerged as a promising strategy in preventing neuronal cell death and alleviating brain ischemia. However, the challenge of overcoming the blood-brain barrier (BBB) hampers the effective delivery of therapeutic drugs to the central nervous system (CNS).

Recent advancements in nanomaterial based optical detection of food additives: a review.

Food additives have become a critical component in the food industry. They are employed as preservatives to decelerate the negative effects of environmental and microbial factors on food quality. Currently, food additives are used for a variety of purposes, including colorants, flavor enhancers, nutritional supplements, .

Starch wall of urea: Facile starch modification to residue-free stable urea coating for sustained release and crop productivity.

Quick leaching of urea fertilizer encourages different coatings, but achieving a stable coating without toxic linkers is still challenging. Here, the naturally abundant bio-polymer, i.e.

Chemical Knockdown of Phosphorylated p38 Mitogen-Activated Protein Kinase (MAPK) as a Novel Approach for the Treatment of Alzheimer's Disease.

Targeted protein degradation (TPD) provides unique advantages over gene knockdown in that it can induce selective degradation of disease-associated proteins attributed to pathological mutations or aberrant post-translational modifications (PTMs). Herein, we report a protein degrader, PRZ-18002, that selectively binds to an active form of p38 MAPK. PRZ-18002 induces degradation of phosphorylated p38 MAPK (p-p38) and a phosphomimetic mutant of p38 MAPK in a proteasome-dependent manner.

Modified cereal bran (MCB) from finger millet, kodo millet, and rice bran prevents high-fat diet-induced metabolic derangements.

Cereal bran consumption improves gastrointestinal and metabolic health. Unprocessed cereal brans have a limited shelf-life and contain anti-nutrient phytochemicals. In the present study, lipids and antinutrients (flavonoids, tannin, and polyphenol) were removed from finger millet, kodo millet and rice bran using chemo-enzymatic processing.

Lycopene: Sojourn from kitchen to an effective therapy in Alzheimer's disease.

Reports on a significant positive correlation between consumption of carotenoid-rich food and prevention of Alzheimer's disease (AD) led to the investigation of carotenoids for the treatment and prevention of AD. More than 1100 types of carotenoids are found naturally, out of which only around 50 are absorbed and metabolized in human body. Lycopene is one of the most commonly ingested members of fat-soluble carotenoid family that gives vegetables and fruits their red, yellow, or orange color.

Organ-restricted delivery through stimuli-responsive nanocarriers for lung cancer therapy.

Lung Cancer (LC) is the malignant tumor of the lungs which is defined by the unrestricted cell development in the lung tissues which if left untreated may migrate to different regions of the body. LC accounts for 12% of the total cancer diagnosis and is among the most occurring malignancies in both genders. Radiotherapy, surgery, and chemotherapy are the treatment options for LC.

Intrarectal Capsazepine Administration Modulates Colonic Mucosal Health in Mice.

Antagonism of transient receptor potential vanniloid-1 (TRPV1) and desensitization of transient receptor potential ankyrin-1 (TRPA1) nociceptors alleviate inflammatory bowel diseases (IBD)-associated chronic pain. However, there is limited literature available about their role in regulating the mucosal layer, its interaction with host physiology, and luminal microbial community. The present study focuses on the effects' intra rectal administration of capsazepine (modulator of TRPA1/TRPV1 expressing peptidergic sensory neurons) on colonic mucus production and gut health.

Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides for the Lungs.

Nucleic acids, both DNA and small RNAs, have emerged as potential therapeutics for the treatment of various lung disorders. However, delivery of nucleic acids to the lungs is challenging due to the barrier property imposed by mucus, which is further reinforced in disease conditions such as chronic obstructive pulmonary disease and asthma. The presence of negatively charged mucins imparts the electrostatic barrier property, and the mesh network structure of mucus provides steric hindrance to the delivery system.