Mechanistic roles of long non-coding RNAs in DNA damage response and genome stability.

To maintain genomic stability, cells have evolved complex mechanisms collectively known as the DNA damage response (DDR), which includes DNA repair, cell cycle checkpoints, apoptosis, and gene expression regulation. Recent studies have revealed that long non-coding RNAs (lncRNAs) are pivotal regulators of the DDR. Beyond their established roles in recruiting repair proteins and modulating gene expression, emerging evidence highlights two particularly intriguing functions.

Vanadium shows no effect in stress-induced hyperthermia and the tail suspension test in healthy mice.

Vanadium (V) is a trace element in the environment; it is detected in soil, water, air, dust, and food products. V-containing compounds have shown therapeutic potential in the treatment of diabetes. However, studies on the effects of V on animal behavior remain limited and sporadic.

Intracellular Galectin-3 as a Crucial Regulator of Foam Cell Formation and Apoptosis Progression through the Modulation of Membrane Lipid Rafts.

Background: Atherosclerosis, a leading cause of cardiovascular disease (CVD) mortality worldwide, is characterized by dysregulated lipid metabolism and unresolved inflammation. Macrophage-derived foam cell formation and apoptosis contribute to plaque formation and vulnerability. Elevated serum galectin-3 (Gal-3) levels are associated with increased CVD risk, and Gal-3 in plaques is strongly associated with macrophages.

Combined SHR and SIRI biomarkers predict increased coronary heart disease risk in type 2 diabetes.

Coronary heart disease (CHD) is a leading cause of morbidity and mortality; patients with type 2 diabetes mellitus (T2DM) are at particularly high risk, highlighting the need for reliable biomarkers for early detection and risk stratification. We investigated whether combining the stress hyperglycemia ratio (SHR) and systemic inflammation response index (SIRI) improves CHD detection in T2DM. In this retrospective cohort of 943 T2DM patients undergoing coronary angiography, associations of SHR and SIRI with CHD were evaluated using multivariable logistic regression and restricted cubic splines; robustness was examined with subgroup and sensitivity analyses.

Perovskite Nanozyme-Mediated Sonocatalytic Therapy: A Mitochondrion-Targeted Strategy for Enhanced Cancer Therapy.

The generation of reactive oxygen species (ROS) through nanozyme-mediated sonocatalytic therapy has demonstrated remarkable therapeutic efficacy in the field of cancer. Nevertheless, it remains a significant challenge for nanozymes with a single catalytic active center to generate sufficient ROS via Fenton or Fenton-like reactions to effectively induce tumor cell death. In order to enhance the catalytic efficacy, we devised and synthesized a multiple active centre and mitochondrial-targeted perovskite nanozyme (NCFP), doped with cobalt (Co) element, and incorporated 4-carboxybutyltriphenylphosphonium bromide (TPP) as a mitochondrial targeting marker for ultrasound (US)-assisted enzyme-like catalytic treatment of tumors.

Microwave Spectroscopy and Structure of the 1-Fluoronaphthalene···HO Complex: Two Hydrogen Bonds Make the Complex a Rigid Rotor.

The microwave spectrum of the complex formed between 1-fluoronaphthalene and HO has been recorded using a chirped pulse Fourier transform microwave spectrometer within the frequency range of 2.0 to 8.0 GHz, with neon as the carrier gas.

Principles of Industry-Academic Partnerships Informed by Digital Mental Health Collaboration: Mixed Methods Study.

Background: Cross-sector collaboration is increasingly recognized as essential for addressing complex health challenges, including those in mental health. Industry-academic partnerships play a vital role in advancing research and developing health solutions, yet differing priorities and perspectives can make collaboration complex.

Objective: This study aimed to identify key principles to support effective industry-academic partnerships, from the perspective of industry partners, and develop this into actionable guidance, which can be applied across sectors.

A Self-Guided Digital Mental Health Promotion Service Targeting Young People: Protocol for a Randomized Controlled Trial.

Background: The high and increasing rate of poor mental health among young people is a matter of global concern. Experiencing poor mental health during this formative stage of life can adversely impact interpersonal relationships, academic and professional performance, and future health and well-being if not addressed early. However, only a few of those in need seek help.

Correction: Factors Affecting the Receptiveness of Chinese Internists and Surgeons Toward Artificial Intelligence-Driven Drug Prescription: Protocol for a Systematic Survey Study.

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Understanding and Addressing Challenges With Electronic Health Record Use in Gynecological Oncology: Cross-Sectional Survey of Multidisciplinary Professionals in the United Kingdom and Co-Design of an Integrated Informatics Platform to Support Clinical Decision-Making.

Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.

Quantum Chemical Modeling of Superbase-Mediated Self-Organization of Pyrroles from Acetylenes and Nitriles.

In this work, the superbase-mediated self-organization of tetrasubstituted pyrroles from three molecules of acetylenes and one molecule of nitriles was theoretically investigated. On the example of interaction of phenylacetylene with benzonitrile in the KOBu/DMSO medium, three possible pathways of the assembly of 2-benzyl-3,5-diphenyl-4-phenylethynyl-1-pyrrole have been studied using a combined B2PLYP-D3/6-311+G**//B3LYP-D3/6-31+G* quantum chemical approach. The calculated activation barriers correspond to mild reaction conditions (room temperature for 15 min).

Evaporation of Ethanol from Liquid Ethanol and Water-Ethanol Mixtures: Mechanism, Kinetics, and Free Energy Changes for Different Compositions of the Mixtures.

Understanding the evaporation mechanism of liquid ethanol and ethanol-water binary mixtures is important for numerous scientific and industrial processes. The amount of water in liquid water-ethanol mixtures can significantly affect how quickly ethanol molecules evaporate. Here, we study the mechanism and rate of evaporation of ethanol from pure liquid ethanol and ethanol/water binary mixtures through both unbiased molecular dynamics simulations and biased simulations using the umbrella sampling method.

Construction of Zeolite Framework-Anchored Rh-(O-Zn) Sites for Ethylene Hydroformylation.

Zeolite-confined Rh-based catalysts have emerged as promising heterogeneous candidates for olefin hydroformylation. However, they face challenges of reactant- and product-induced Rh leaching and aggregation. Herein, zeolite framework-anchored Rh-(O-Zn) sites were designed and are shown to have remarkable activity and stability for gas-phase ethylene hydroformylation.

Enhancing Readability of Lay Abstracts and Summaries for Urologic Oncology Literature Using Generative Artificial Intelligence: BRIDGE-AI 6 Randomized Controlled Trial.

Purpose: To evaluate a generative artificial intelligence (GAI) framework for creating readable lay abstracts and summaries (LASs) of urologic oncology research, while maintaining accuracy, completeness, and clarity, for the purpose of assessing their comprehension and perception among patients and caregivers.

Methods: Forty original abstracts (OAs) on prostate, bladder, kidney, and testis cancers from leading journals were selected. LASs were generated using a free GAI tool, with three versions per abstract for consistency.

Complement Factor I Deficiency With Acute Hemorrhagic Leukoencephalitis and Longitudinally Extensive Transverse Myelitis: A Case Report.

Objectives: Complement factor I (CFI) deficiency is a rare condition that can present with fulminant relapsing CNS autoinflammation. In this report, we highlight the utility of genetic testing in unexplained CNS autoinflammation.

Methods: This case report describes a young adult with partial CFI deficiency, presenting with acute hemorrhagic leukoencephalitis and longitudinally extensive transverse myelitis.

Germline Findings From Tumor-Only Comprehensive Genomic Profiling in the RATIONAL Study: A Missed Opportunity?

Purpose: Tumor comprehensive genomic profiling (CGP) may detect potential germline pathogenic/likely pathogenic (P/LP) alterations as secondary findings. We analyzed the frequency of potentially germline variants and large rearrangements (LRs) in the RATIONAL study, an Italian multicenter, observational clinical trial that collects next-generation sequencing-based tumor profiling data, and evaluated how these findings were managed by the enrolling centers.

Patients And Methods: Patients prospectively enrolled in the pathway-B of the RATIONAL study and undergoing CGP with the FoundationOne CDx assays were included in the analysis.

Cycling-Based Telerehabilitation: Acceptability and Feasibility Study.

Background: Telerehabilitation is a promising solution to provide continuity of care. Most existing telerehabilitation platforms focus on rehabilitating upper limbs, balance, and cognitive training, but exercises improving cardiovascular fitness are often neglected.

Objective: The objective of this study is to evaluate the acceptability and feasibility of a telerehabilitation intervention combining cognitive and aerobic exercises.

Identifying Success Factors for Optimizing COVID-19 Vaccine Uptake Among Indigenous Populations in Taiwan: Cross-Sectional Questionnaire Survey.

Background: The COVID-19 pandemic has devastated economies and strained health care systems worldwide. Vaccination is crucial for outbreak control, but disparities persist between and within countries. In Taiwan, certain indigenous regions show lower vaccination rates, prompting comprehensive inquiries.

Predicting Unplanned Readmission Risk in Patients With Cirrhosis: Complication-Aware Dynamic Classifier Selection Approach.

Background: Cirrhosis is a leading cause of noncancer deaths in gastrointestinal diseases, resulting in high hospitalization and readmission rates. Early identification of high-risk patients is vital for proactive interventions and improving health care outcomes. However, the quality and integrity of real-world electronic health records (EHRs) limit their utility in developing risk assessment tools.

Effect of Samarium Doping on the Energy Storage Properties of Bismuth Sodium Titanate-Based Lead-Free Ceramics.

Lead-free electroceramics have attracted significant research interest as alternatives to lead-containing systems due to concerns related to lead's toxicity to human health and the environment. Solid solutions based on bismuth sodium titanate (BNT) and barium titanate (BT), particularly those with compositions near the morphotropic phase boundary (MPB), such as 0.94 BiNaTiO-0.

Hamiltonian Grid-Based QM/MM Method with Mean-Field Embedding for Simulating Arbitrary Slab Geometries.

The quantum mechanics/molecular mechanics (QM/MM) method is a powerful approach for investigating solid surfaces in contact with various types of media, since it allows for flexible modeling of complex interfaces while maintaining an all-atom representation. The mean-field QM/MM method is an average reaction field model within the QM/MM framework. The method addresses the challenges associated with the statistical sampling of interfacial atomic configurations of a medium and enables efficient calculation of free energies.

Precise Modulation of Zeolite Acidity by Alkali Metal Ions for Enhancing Catalytic Performance in CO Cycloaddition Reactions.

The CO cycloaddition route is an effective way to achieve efficient conversion and utilization of CO. Zeolites with diverse topologies and tunable acidic sites can efficiently promote the cycloaddition reaction of CO with epoxides. The exchangeable cations in zeolites have a great influence on the performance of the CO cycloaddition, but there are few studies on it.