Outcomes of 5-aminosalicylates withdrawal due to non-adherence in ulcerative colitis patients: A step toward evaluating intermittent therapy.

Background: 5-aminosalicylates (5-ASA) are the primary treatment for mild to moderate ulcerative colitis (UC). Maintenance therapy with 5-ASA has been shown to reduce both the risk of relapse and colorectal cancer.

Aim: To evaluate the outcomes of 5-ASA withdrawal due to non-adherence in UC patients while in remission on monotherapy.

Safety and Clinical Outcome of Bleomycin-Electrosclerotherapy (BEST) Treating Lymphatic Malformations (LMs).

Introduction: Bleomycin-electrosclerotherapy (BEST) is a novel treatment for slow-flow vascular malformations (SFVMs), most studied in venous malformations. This study specifically evaluated its safety and clinical outcome in lymphatic/lymphatic-dominant lympho-venous malformations (LMs/ld-LVMs).

Materials And Methods: A monocentric cohort with symptomatic LMs or ld-LVMs treated by BEST was retrospectively assessed.

Cooperative Catalytic Role of Co and Mn Sites on LaCo Mn O Perovskite Nanoparticles in CO and NO Oxidation.

Perovskites have significant potential to improve efficiency, reduce the costs of conventional oxidation catalysts, and contribute to cleaner and more sustainable energy solutions. However, numerous structural factors influencing their catalytic performance are still a subject to debate. In this study, simple perovskite nanoparticles in the form of LaCoO (LC) and LaMnO (LM), as well as LaCo Mn O (LCM)-mixed B-site perovskites with different B-site cations, were synthesized and their performances in CO oxidation and NO oxidation reactions were examined.

Steroid Injection in the Treatment of Foreign Body-Associated Chronic Flexor Tenosynovitis: Never Without Ultrasound.

Background: Although cases of tenosynovitis associated with foreign bodies are documented in the literature, there is no reported instance of the treatment of foreign body-associated tenosynovitis with ultrasound (US)-guided steroid injection. The use of corticosteroid injection under US guidance for flexor tenosynovitis associated with foreign bodies is a noteworthy subject.

Case Report: In this case report, we present the contribution of US-guided targeted steroid injection to the treatment of flexor tenosynovitis of the third finger of the left hand associated with a foreign body.

The Heart Under Pressure: Traumatic Gerbode Defect and Aortic Dissection After a Tire Explosion: A Case Report and Literature Review.

We report an unusual case of a 13-year-old boy who sustained multiple traumatic cardiac injuries-including ventricular septal and Gerbode defects, aortic dissection, and severe tricuspid regurgitation (TR)-following a high-pressure truck tire explosion. The patient underwent successful endovascular and surgical repair, with full recovery observed at the 1-year follow-up. This case highlights the importance of thorough evaluation and individualized management in pediatric patients with complex cardiac trauma resulting from uncommon high-energy mechanisms.

Shear Wave Elastography for the Assessment of Thenar Muscle Elasticity in Trapeziometacarpal Osteoarthritis: A Cross-Sectional Study.

Purpose: Although recent studies have emphasized the importance of the adductor pollicis (AdP) and first dorsal interosseous (FDI) muscles in maintaining trapeziometacarpal (TMC) joint function, the viscoelastic properties of these muscles in the presence of TMC osteoarthritis (OA) remain unclear. This study aimed to investigate differences in the elasticity of the AdP and FDI muscles in patients with TMC OA, thereby contributing to the understanding of muscular changes associated with the disease.

Methods: Eighteen patients with TMC OA (29 thumbs) and 13 age- and sex-matched asymptomatic controls (26 thumbs) were included.

Neurological involvement in children with familial Mediterranean fever: a systematic review.

Background: Although typical findings of familial Mediterranean fever (FMF), such as brief fever episodes and abdominal or chest pain, have been largely described, little is known about the neurological manifestations of the disease in childhood.

Methods: A systematic search of the literature was conducted in PubMed/Medline, Cochrane, and Web of Science databases in accordance with the PRISMA guidelines, using MeSH terms related to FMF and neurological manifestations. Studies involving patients under 18 years of age diagnosed with FMF with neurological manifestations were included.

Comparison of forces applied to oropharyngeal tissues with different blades during laryngoscopy in a standard pediatric endotracheal intubation model.

Objectives: To measure the pressure exerted on the base of the tongue during endotracheal intubation using a standard pediatric model.

Methods: The study was conducted in October-November 2022 at Hacettepe University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey. Anesthesiology residents performed intubations with Glidescope-LoPro-T2, Storz-C-MAC-paediatric-D-blade, and standard-Macintosh-1-blade on the same pediatric intubation model.

Evaluation of creative project production performance in mathematical logic and computational thinking skills among gifted high school students.

This study examines the experiences of gifted high school students in transforming mathematical logic knowledge and skills into creative project productivity and computational thinking skills (CTS) through their logic-based project productions. A sequential exploratory mixed-methods research design was employed, involving 153 gifted youth. In the qualitative phase, a case study was used to examine the experiences of participants who attended the Logic-based Project Production and Management Program (PPMP) over 25 weekly sessions.

Living with and without AI: A mixed-methods study on AI usage, addiction, and 'AIlessphobia' in nursing students.

Aim: The aim of this study is to examine nursing students' attitudes toward AI use, their patterns of use and levels of AI addiction, as well as to evaluate the impact of emerging fears such as AIlessphobia.

Background: Generative artificial intelligence (AI) is rapidly evolving and is increasingly being used among university students. Concepts such as "AIlessphobia" -the fear of being without AI- highlight the emergence of these issues.

Association of dietary inflammatory index with serum asprosin and omentin levels in women with prediabetes.

Background And Objectives: The objective of present study was to assess the relationship between the Dietary Inflammatory Index (DII) and the Glycemic Index (GI), serum TNF-α (tumor necrosis factor alpha), IL-6 (interleukin 6), serum asprosin, and omentin adipokines in prediabetic adult women.

Methods: The study included a total of 60 women: 30 women with prediabetes, aged 19-50 years, with a body mass index (BMI) ranging from 25 to 35 kg/m, and 30 healthy women with similar age and BMI as the control group. Dietary data for calculating DII and GI were obtained from food frequency questionnaires and food consumption records, respectively.

Clinicians' view on non-adherence: sharing expert opinion.

Introduction: Medication non-adherence (NA) remains a persistent challenge across all medical specialties, contributing to adverse patient outcomes and increased healthcare burdens. While numerous studies have explored patient-related factors influencing adherence, the perspectives of healthcare professionals remain underrepresented in literature. This study aims to document the individual experiences of seven international physicians across diverse medical fields, highlighting barriers, detection methods, and strategies employed to address NA in their daily practice.

might serve as a new negative prognostic biomarker in gastric cancer.

Unlabelled: Gastric cancer is a common malignancy with a high mortality rate. Improvement in survival has been observed with therapies targeting HER2 and Claudin 18.2 or with immune checkpoint inhibitors.

Potential Role of SGLT-2 Inhibitors in Improving Allograft Function and Reducing Rejection in Kidney Transplantation.

Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have demonstrated renoprotective and cardioprotective benefits beyond their antiglycemic effects. Their potential utility in kidney transplant recipients (KTRs) for preserving graft function and reducing rejection risk is currently under active investigation. Preliminary studies indicate that SGLT-2i therapy stabilizes estimated glomerular filtration rate (eGFR), decreases glomerular hyperfiltration, and improves metabolic outcomes in KTRs.

Responses of Different Artificial Intelligence Systems to Questions Related with Short Stature as Assessed by Pediatric Endocrinologists.

Objective: Artificial intelligence (AI) is increasingly utilized in medicine, including pediatric endocrinology. AI models have the potential to support clinical decision-making, patient education, and guidance. However, their accuracy, reliability, and effectiveness in providing medical information and recommendations remain unclear.

Temporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.

Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.

Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols.

Learning styles or study approaches in medical schools: a study of a pebble thrown into the water.

Background: This study investigates the relationships between medical students’ learning styles and their study approaches. While learning styles have been criticized and debated, study approaches are recognized for their association with academic success. Understanding these dynamics can enhance educational practices in medical education by catering to diverse student needs.

A diagnostic algorithm to evaluate elevated C-reactive protein levels in juvenile systemic lupus erythematosus.

Objective: C-reactive protein (CRP) levels are generally not correlated with systemic lupus erythematosus (SLE) disease activity. We aimed to develop an algorithm to evaluate juvenile SLE (JSLE) patients with elevated CRP.

Methods: JSLE patients diagnosed at <18 years were included.

Teamwork effectiveness in intensive care units: development and validation of a brief and reliable assessment tool (TES-ICU).

Background: Effective teamwork is essential for patient safety and quality of care in intensive care units (ICUs), where complexity, high cognitive demands, and multidisciplinary collaboration prevail. Despite its critical role, there is a lack of validated instruments specifically designed to assess teamwork effectiveness in ICUs. This study aimed to develop and validate a context-specific tool-the Teamwork Effectiveness Scale in Intensive Care Units (TES-ICU).

Perceived food literacy in women with gynecologic cancer receiving chemotherapy.

Purpose: Cancer patients must develop food literacy to successfully adapt to dietary changes and enhance their health management. This study is aimed at assessing the perceived food literacy of women undergoing chemotherapy for gynecologic cancer.

Method: This descriptive, cross-sectional study was conducted with 136 gynecologic cancer patients undergoing chemotherapy at the Chemotherapy Unit of the Department of Gynecologic Oncology Surgery in a university hospital in Turkey.