Asparaginase Premedication With Hydrocortisone Decreases Hypersensitivity Reactions.

Background: While pegylated Escherichia coli asparaginase (PEG) is an integral component of leukemia and lymphoma treatment, hypersensitivity reactions (HSR) remain a common adverse event, often resulting in adjustments to the treatment regimen, increasing the burden on patients and families. HSR to asparaginase often indicates a transition to Erwinia asparaginase (ERW), which requires patients to return to the hospital 6 times for subcutaneous injections to replace one dose of IV PEG. Previous trials have demonstrated rates of HSR to pegylated E.

Indications for haematopoietic cell transplantation and CAR-T for haematological diseases, solid tumours and immune disorders: 2025 EBMT practice recommendations.

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the ninth special EBMT report on indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres.

Cadmium Availability in a Soil-Rice System Receiving Four Consecutive Seasons of Straw Removal.

Cadmium (Cd) pollution in rice agroecosystems has become a pressing worldwide environmental challenge. Straw return leads to Cd re-entering the soil, yet the impact of straw removal (SR) on Cd mobility and bioavailability within this system remains unclear. We implemented a four-season field study to evaluate how different SR intensities (NSR: no rice straw was removed; HSR: half of the rice straw was removed; TSR: all the rice straw was removed) influence Cd availability in this system.

Usefulness and timing of the third-trimester ultrasound scan: a review of guidelines and underlying evidence.

Objectives: Recommendations regarding the use of third-trimester ultrasound lack universal consensus. Yet, there is evidence which supports its value in assessing fetal growth, fetal well-being, and a number of pregnancy-related complications. This literature review evaluates the available scientific evidence regarding its applications, usefulness, and the timing of the third-trimester scan in a low-risk population.

Real incidence and management of patients with suspected iodinated contrast media allergy in our area.

Introduction: Adverse reactions to iodinated contrast media (ICM) are very common due to its widespread use. Despite the fact that overall incidence of hypersensitivity reactions (HSRs) to ICM is low, the risk of severe outcomes needs a careful patient evaluation and management.

Methods: We conducted a retrospective epidemiological study that included patients referred to our Allergy Unit for suspected allergy to ICM in whom we carried out a protocolized allergic study based on skin and drug provocation tests (DPT).

Adverse Reactions to Taxanes in Premedicated Cancer Patients: A Prospective Observational Study.

Introduction:  Taxanes, including paclitaxel, docetaxel, and cabazitaxel, are widely used anticancer agents that disrupt cell division by binding to microtubules, but are associated with significant adverse reactions, particularly infusion-related reactions (IRRs), such as flushing, urticaria, and respiratory symptoms. Despite premedication with steroids, antihistamines, and antiemetics per guidelines, taxane-induced side effects remain prevalent and can result in treatment delays or discontinuation, impacting patient outcomes. This study aimed to observe and document the incidence and spectrum of adverse reactions to taxanes among premedicated cancer patients to improve management and overall chemotherapy success.

Encampment Medicine: Innovating Care Delivery in a Community of Tiny Shelters on Veterans Affairs Grounds.

Veterans experiencing homelessness face barriers to traditional U.S. Department of Veterans Affairs (VA) care, even when temporarily housed on VA grounds.

Hospitals in Some States Under Report Medicaid Discharge Counts in Cost Report Data.

Objective: To investigate discrepancies in Medicaid enrollees' hospital discharges reported in two data sources widely used in health services research: the CMS Hospital Cost Report Information System (HCRIS) and the T-MSIS Analytic Files (TAF).

Study Setting And Design: This is a descriptive study comparing inpatient discharges reported in the two data sets. We included inpatient admissions at general hospitals in 2020-2021.

Construct validity, intrarater and interrater reliability of the Italian version of the systematic screening of handwriting difficulties (SOS) test in people with Parkinson's disease.

Background: The "Systematic Screening of Handwriting Difficulties in Parkinson's Disease" (SOS) test is the only tool specifically designed to evaluate handwriting in people with Parkinson's Disease (pwPD). It is language specific.

Objective: To assess the construct validity, intrarater and interrater reliability of the Italian version of the SOS test.

A Critical Examination of the Certified Community Behavioral Health Clinic Model: Provider Perceptions and Themes.

Objective: To explore the experiences of providers from two community behavioral health agencies involved in the implementation of Certified Community Behavioral Health Clinics (CCBHCs).

Study Setting And Design: This qualitative study was conducted as part of a larger evaluation of CCBHC implementation outcomes in two community-based behavioral health agencies. Ninety-one participants, including case managers, counselors, care coordinators, and leadership teams from both agencies, participated in focus group discussions to share their experiences regarding the implementation of the CCBHC model within their organizations.

Advances, challenges, and future directions in trauma-related Findable, Accessible, Interoperable, Reusable (FAIR) data efforts.

Findable, Accessible, Interoperable, and Reusable (FAIR) data advances are becoming more common and more important across research fields given the large amount of research data in need of synthesis and application. Many novel methods improve the efficiency and accuracy of data reuse, combination, and synthesis, which is necessary given that there are over 500 published randomized controlled trials of posttraumatic stress disorder treatments in adults; however, these methods are still relatively new to the field of traumatic stress research. We provide a brief overview of relevant FAIR data efforts from other fields and within trauma health care and research; share examples of trauma-related FAIR data efforts to demonstrate recent advances and challenges; and suggest potential next steps to continue making trauma data more FAIR.

Clinical presentation and echocardiographic characteristics of women with peripartum cardiomyopathy: Insights from the Italian Multicentre Registry.

Background: Peripartum cardiomyopathy (PPCM) is a rare, life-threatening form of heart failure occurring in late pregnancy or postpartum, with variable clinical course and outcomes. We report preliminary clinical and echocardiographic findings from a national Italian registry of PPCM patients METHODS: The study was approved by the institutional Ethics Committee and registered at ClinicalTrials.gov (NCT05878041).

Can Machine Learning predict therapeutic outcomes in affective and not affective psychosis? A systematic review and meta-analysis.

Machine learning (ML) could be useful in identifying reliable predictors of treatment response in affective and not affective psychoses, potentially helping to propose personalized interventions. In this systematic review and meta-analysis, we evaluated studies exploiting ML algorithms to predict the improvement of psychotic symptoms, cognition and quality of life in psychoses related to different treatments. We searched MEDLINE (PubMed), Web of Science, and PsycINFO databases updated until February 2024, identifying 64 articles published in English in peer-reviewed journals.

A Causal Machine Learning Framework for Estimating the Impact of Cancer Diagnosis on Receipt of Advance Care Planning.

Objective: Develop a causal machine learning (causal ML) framework for estimating how a diagnosis (cancer in this study) affects the likelihood of receiving a specific health care service (advance care planning in this study) and associated heterogeneity.

Study Setting And Design: Our proposed framework leverages the causal forest method, combined with a population-weighted resampling and averaging over estimations strategy, to estimate average treatment effects (ATEs) and conditional average treatment effects (CATEs). Post hoc, we used best linear projections to identify covariates associated with variation in the CATEs.

The Impact of Team-Based Ordering Workflows on Ambulatory Physician EHR Time, Order Volume, and Visit Volume.

Objective: To analyze national rates of team-based ordering and evaluate changes in key outcomes following adoption.

Study Setting And Design: We conducted an observational pre-post intervention-comparison study of 249,463 ambulatory physicians across 401 organizations using the Epic EHR. Our intervention was the adoption of team-based ordering, measured as the proportion of orders involving team support.

[Health services research as a job market: A document analysis of job advertisements].

Introduction: Since the mid-2010s, health services research (HSR) in Germany has been increasingly institutionalized. However, little is known about actual career paths within the field. The aim of this study was to describe the HSR job market in Germany, both in general terms and specifically for graduates of health services research master degree programs.

Clinician Specialties, Quality Score and Shared Savings Receipt in Accountable Care Organizations.

Objective: To assess the relationship between the changing Accountable Care Organizations-ACO workforce and ACOs' shared savings earnings and quality performance.

Data Sources: Medicare Shared Savings Program-MSSP provider-level research identifiable files, performance year financial and quality report public use files, and National Physician Compare data (2013-2021).

Study Setting And Design: We characterized 865 MSSPs, separately pre- (2013-2019) and post-pandemic (2020-2021) according to the percentage of primary care physicians (PCPs), non-physicians, specialists, and other specialty, financial risk model, assigned Medicare beneficiary demographics, clinical risk factors, and provider supply by specialty within the MSSP's primary service state, (total and per-capita) shared savings earnings/losses owed and quality score.

Caregiving Network Characteristics and Mental Health Care Utilization by Older Adults.

Background: Rates of mental health service use are low among older adults. This study examined associations between mental health care utilization and caregiving network characteristics, including caregiving network size, caregiving intensity, the presence of formal helpers, and primary caregiver characteristics.

Methods: Using a sample of 692 respondents in the health and retirement study (HRS) with linkage to veterans affairs healthcare records (mean age = 78.

Impact of letermovir on Cytomegalovirus-specific T-cells reconstitution after allogeneic hematopoietic stem cell transplantation in the post-transplant cyclophosphamide era.

Not available.

Management of cocaine-induced midline lesion (CIMDL) extended to skull base: a case report and systematic review.

Purpose: Cocaine-induced midline destructive lesions (CIMDL) represent a rare but severe consequence of intranasal cocaine abuse, occasionally progressing to skull base involvement with life-threatening complications. The aim of this manuscript is to describe an exceptional case of CIMDL with clival destruction and brainstem exposure, and to review current management strategies based on a systematic literature review.

Methods: We report a unique case of a 39-year-old woman with CIMDL extending to the clivus, resulting in encephalocele with basilar artery and brainstem exposure.

Intrinsic disorder and fuzzy interactions drive multiple functions of HMGB1.

HMGB1, a multitasking protein, is scrutinized here through the lens of the 'fuzzy interactions' driven by its intrinsically disordered regions (IDRs). Although the multiple intracellular and extracellular functions of this protein have been studied for decades, viewing HMGB1 as fuzzy and dynamic provides a novel perspective. Recent breakthroughs emphasize the crucial role of its IDRs, especially the acidic C-terminal tail, in mediating dynamic multivalent interactions.