Demystifying Intricate Factors of Nutritional Anemia Beyond Iron Deficiency-A Narrative Review.

Background & Aims: Nutritional anemia is a widespread public health issue, impacting about one-quarter of the global population (24.3% in 2021; ∼1.92 billion people).

Physicochemical characterization of polyoxyethylene (POE)-based nonionic surfactants in single and mixed micellar environments for anticancer drug solubilization enhancement.

This work reports the nanoscale micellar formation in single and mixed surfactant systems by combining an amphiphilic graft copolymer, Soluplus® (primary surfactant), blended with other polyoxyethylene (POE)-based nonionic surfactants such as Kolliphor® HS15, Kolliphor® EL, Tween-80, TPGS®, and Pluronics® P123 in an aqueous solution environment. The solution behaviour of these surfactants as a single system were analyzed in a wide range of surfactant concentrations and temperatures. Rheological measurements revealed distinct solution behaviour in the case of Soluplus®, ranging from low-viscosity () and fluid-like behavior at ≤20% w/v to a highly viscous state at ≥90% w/v, where the loss modulus ('') exceeded the storage modulus (').

Immunoinformatics-guided vaccine design: A review with case study on Marburg virus.

A primary concern for world health is the emergence of new infectious diseases. Conventional vaccine development techniques are time-consuming and often limited by issues such as antigen availability and safety concerns. Immunoinformatics, a computational approach that integrates immunology and informatics, presents a promising solution for accelerating vaccine design.

Red blood cell extracellular vesicles: new frontiers in hematological biomarker discovery.

Extracellular vesicles (EVs) offer promising opportunities in hematology for improved diagnostics, prognostics, and therapeutics, making them valuable tools in the molecular landscape. EVs derived from red blood cells (RBCs) are the primary source of EVs in the bloodstream. They perform several critical biological and physiological functions, such as facilitating intercellular communication and transferring biomolecules like DNA, RNA, and proteins.

Comprehensive Network pharmacology and in vitro investigation of L-mimosine: unveiling multi-targeted therapeutic potential against breast cancer.

Breast cancer remains the leading cause of mortality among women globally, primarily due to its heterogeneity and complex pathophysiology. Conventional treatments such as surgery, radiation therapy, and chemotherapy often face limitations, including significant side effects and the development of drug resistance. Consequently, there is an urgent need to identify novel, effective natural compounds with anti-tumor properties.

Natural compounds attenuate combined chromium and arsenic-induced oxidative stress and nephritic apoptosis by activating the Nrf2/Keap1 signaling and associated xenobiotic metabolizing enzymes.

Chromium (Cr) and arsenic (As) pose a threat to the exposed population, leading to various renal ailments. Although individual toxicity has been well investigated, little is known about their combined effects. In light of the mounting concern over the environmental impact of heavy metals, the current study investigated the potential benefits of the selected nutraceuticals, i.

Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals.

The progression of inflammation during sepsis represents a multifaceted biological cascade that requires effective therapeutic interventions to improve survival. In septic neonatal foals, oxidative stress (OS) arises due to a compromised antioxidant defense system. Oxidative stress may disrupt the functionality of redox-sensitive organelles, such as the endoplasmic reticulum (ER).

Sennoside A from Cassia angustifolia as a mixed-type inhibitor of DPP-IV: Integrative in vitro, in silico, and kinetic characterization.

Type 2 diabetes mellitus represents a growing global health crisis, with India alone projected to surpass 124 million cases by 2040. Its multifactorial pathophysiology-including oxidative stress, insulin resistance, β-cell dysfunction, and impaired incretin signaling-is often inadequately addressed by existing therapies, which may lose efficacy and cause side effects over time. This highlights the need for safer, multi-targeted agents from natural sources.

Partition constants of alcohols and surfactants in mixed alcohol/10-carbon dimeric amphiphile aggregates from NMR-diffusion experiments.

The partition constants (-values) of primary alcohols in solutions containing aggregates of some symmetric dimeric (gemini) surfactants ,'-dimethyl,'-didecyl-α,ω-alkanediammonium dibromide (10--10 gemini surfactants) have been computed from the diffusion coefficients NMR spectroscopy. From the partition constants, thermodynamic partition coefficients and Gibbs energies of transfer for the alcohols from the bulk DO phase to the dimeric aggregate phase have been calculated. For 10-6-10 and 10-8-10 surfactants, the partition constants for two primary alcohols, 1-butanol (COH) and 1-pentanol (COH), increased with increasing the amount of the surfactant in the solution, while the thermodynamic partition coefficients and the calculated Gibbs transfer energies were constant with increasing surfactant concentration.

Ab-initio analysis of CrX (X = S, Se and Te) monolayers as bifunctional electrocatalysts for oxygen reduction and evolution reaction in nonaqueous lithium-oxygen batteries.

Lithium-oxygen batteries are next-generation battery devices due to lightweight nature and high energy density with compared to conventional Li-ion batteries. These batteries consist a metal anode terminal and an oxygen diffused cathode terminal, in which oxygen is used as a reactant with metal atoms from surrounding air. Nonetheless, these systems facing the problems related to sluggish kinetics and higher overpotential due to formation of insoluble products at negative electrode during redox reaction.

Integrative bioinformatics and drug repurposing for metastatic prostate cancer: identifying novel therapeutic targets by transcriptional profiling and molecular Modeling.

Metastasis is one of the leading factors of cancer-related deaths worldwide. New potential targets and treatment strategies are needed to extend survival and enhance the quality of life for these patients. We performed an in-depth bioinformatics analysis to identify potential genes and associated potential therapeutic compounds for metastasis of prostate adenocarcinoma.

Management of intra-bony defects using nano HA+PRF over its combination with a diode laser.

Patients with periodontitis frequently have intra-bony defects. Therefore, it is of interest to evaluate the use of a diode laser and a bone graft (nano hydroxyapatite [HA] + platelet rich fibrin [PRF]) in healing of intra-bony defects. In this split-mouth evaluation, 20 patients with bilateral intra-bony defects were divided into 2 groups as; Group I (control) - nano HA + PRF and Group II (Test group)--bone graft (nano HA + PRF)+ diode laser and treated accordingly.

Detecting oral cancer in edentulous patients during denture fabrication by Prosthodontists.

Detection of potentially malignant disorders (PMDs) and oral cancer among completely edentulous patients by Prosthodontists is of interest. Hence, a thorough soft tissue examination was conducted at five key stages of denture fabrication on 500 edentulous patients. Information on tobacco and alcohol consumption was collected and biopsies were performed.

Microplastic ingestion in wild zoanthids: first evidence and a global meta-analysis on cnidarian.

Nowadays, microplastics (MPs) are widespread across the planet and are recognized as a major threat to life on Earth. This study investigates the prevalence of microplastics in three species of zoanthids (Palythoa mutuki, Palythoa tuberculosa, and Zoanthus sansibaricus), sediment, and surface water samples collected from four rocky shores of Gujarat state, India. The extraction of MPs was carried out using a standard method.

Investigation of dielectric studies of paracetamol-diethylamine solutions: Experimental and machine learning approach.

This paper discusses about the dielectric studies of binary mixtures of paracetamol (PCM) and Diethylamine (DEA). Parallel resistance (R) and Parallel capacitance (C) measured using a precision LCR meter over a frequency range of 20 Hz-2 MHz at four distinct temperatures, starting from 293.15 K and increasing by 10 K for each subsequent measurement.

Anticancer Efficacy and Metabolomic Profiling of Punica granatum Leaf Extracts: In vitro and In silico Approaches.

Introduction: Current research focuses on identifying and analyzing bioactive metabolites with significant therapeutic properties derived from Punic granatum L. (Pomegranate) leaves.

Methods: The biological potential of these metabolites was evaluated through anticancer activity.

Inferior Vena Cava/Aorta Diameter Index for the Evaluation of Intravascular Volume Status in Children with Idiopathic Nephrotic Syndrome.

Objectives: To correlate the inferior vena cava/aorta diameter (IVC/Ao index) in children with nephrotic syndrome with clinical indicators of volume status, and to compare the IVC/Ao index between children in relapse and in remission.

Methods: This prospective longitudinal study included children aged 2-18 years presenting with relapsed nephrotic syndrome. Low intravascular volume status was diagnosed if two of the three criteria (tachycardia, hypotension, prolonged capillary filling time) were present.

Emerging Trends in Advanced Materials for C─S Coupling Reactions: Design Strategies and Future Perspectives.

The carbon─sulfur (C─S) bond is an essential structural unit in various therapeutic agents, including antibiotics and anticancer drugs. C─S coupling reactions involving organothiols and aryl electrophiles have emerged as a powerful strategy. Recently, C─S coupling using heterogeneous catalysts like metals, metal oxides, and single-atom sites on polymers, 2D materials, and nanoporous metal-organic frameworks (MOFs) has shown promise due to synergistic properties enhancing nanoscale dispersion, stability, activity, recyclability, and control over key textural parameters.

Identification of the HLA-C*18:06 Allele in a Prospective Bone Marrow Donor.

HLA-C*18:06 was identified by a single nucleotide (G>A) substitution at position 275 in HLA-C*18:02.

Recent advances in the bioremediation of wastewater pollutants by using bacterial magnetic nanoparticles and magnetotactic bacteria.

The potential of bacterial magnetic nanoparticles and magnetotactic bacteria has increased significantly in wastewater treatment. Magnetotactic bacteria and their magnetosomes exhibit unique magnetic and structural properties that facilitate the efficient removal of pollutants, including heavy metals, dyes, pesticides, and radionuclides. Unlike chemically synthesized nanoparticles, bacterial magnetosomes are biocompatible, recyclable, and can be manipulated using external magnetic fields, making them suitable for repeated use in treatment systems.

Targeting TRPC6 in podocytopathies: Why clinical translation remains a challenge?

Podocytopathies, driven by injury to glomerular podocytes, are a major cause of proteinuric kidney diseases like focal segmental glomerulosclerosis (FSGS) and diabetic kidney disease (DKD). The transient receptor potential canonical 6 (TRPC6) channel, expressed in podocytes, is critical for maintaining the glomerular filtration barrier. Dysregulation of TRPC6 activity-whether due to gain-of-function mutations or pathological activation-induces excessive calcium influx, leading to podocyte cytoskeletal disruption, oxidative stress, and apoptosis.

Haloalkaliphilic Archaea as Sources of Carotenoids: Ecological Distribution, Biosynthesis and Therapeutic Applications.

The haloalkaliphilic archaea are a group of unique organisms that can thrive in environments with high salinity and alkaline pH. Theses microorganisms have developed various strategies to survive in polyextereme conditions, carotenoids production included as a one of defense mechanism. The ecological distribution of haloalkaliphilic archaea is in soda lakes.

Green Synthetic Strategies for Pyrazole Derivatives: A Comprehensive Review.

Pyrazole derivatives have emerged as a vital class of heterocyclic compounds due to their wide range of biological activities and promising therapeutic applications. In recent years, the shift toward greener and more sustainable chemical practices has fueled interest in the eco-friendly synthesis of pyrazole-based molecules. This review presents recent advancements in the green synthesis of pyrazole scaffolds, with a special focus on methods that avoid hazardous reagents, employ green solvents, utilize renewable energy sources, and incorporate recyclable catalysts.

Clinical presentation of children with lupus nephritis from a low- and middle-income country (LMIC): an initial report from the Indian pSLE Nephritis Registry.

Introduction: Limited prospective data exist on pediatric LN (pLN) from low- and middle-income countries (LMIC), where ethnicity, socioeconomic factors, and healthcare access are likely to differ from high-income countries.

Methods: The Indian Pediatric Lupus Nephritis registry has been running since 2020 across multiple centers in India. Children (≤ 18 years) diagnosed with lupus (as per 2012 SLICC criteria), presenting with nephritis, and confirmed by kidney biopsy are being prospectively enrolled.