Combination of neovestitol and vestitol impair the subgingival multispecies biofilm development.

The aim of this study was to evaluate effects of neovestitol-vestitol fraction (NVF) on an subgingival multispecies biofilm. The 33-species biofilm was formed for seven days using a Calgary device. Starting on day 3, treatments for applied twice daily for 1 min each: NV (400-1,600 µgml), chlorhexidine 0.

Statistical Gems and Cautions From the Statistical Advisory Board of Clinical Oral Implants Research.

Objective: Statistics is fundamental in implant dentistry research, playing a crucial role in study design, data analysis, and interpretation of findings. This editorial, authored by members of the Statistical Advisory Board of Clinical Oral Implants Research, aims to highlight common statistical pitfalls encountered in submitted manuscripts and provide practical recommendations to enhance the quality of statistical reporting.

Materials And Methods: In this editorial, study design considerations, sample size calculation, appropriate selection of statistical tests, multiplicity issues, handling hierarchical data structures, and best practices for data presentation are discussed.

Effects of Lycopene Supplementation on Bone Tissue: A Systematic Review of Clinical and Preclinical Evidence.

: Bone tissue undergoes continuous remodeling, and imbalances in this process can lead to osteometabolic disorders, such as osteoporosis. Thus, bioactive compounds, like lycopene (LYC), have been investigated for their potential protective effects in bone health. This systematic review (SR) aimed to evaluate the effects of LYC supplementation on bone tissue.

Clinical Efficacy of Er,Cr:YSGG Laser for Deepithelialization of Free Gingival Grafts in Gingival Recession Treatment: A Randomized, Split-Mouth Clinical Trial.

: The deepithelialized free gingival graft (DGG) technique provides high-quality connective tissue grafts (CTGs) with predictable outcomes for recession coverage. This study evaluates a novel method of free gingival graft (FGG) deepithelialization using an Er,Cr:YSGG laser (LDEE) for treating multiple gingival recessions. : A split-mouth study was conducted on 46 ( = 46) recessions in nine patients (23 per test and control group).

Dimensional Changes After Different Alveolar Ridge Preservation Techniques for Posterior Region: A Randomised Controlled Clinical Trial.

Aim: Alveolar ridge preservation (ARP) after tooth extraction aims to maintain ridge dimensions for future implant placement. However, limited evidence is available for posterior sites. We evaluated the dimensional changes in posterior extraction sockets using four approaches: modified free gingival graft (MFGG); MFGG with xenograft (MFGG + XG); guided bone regeneration with titanium membrane and xenograft (TM + XG); and unassisted socket healing (USH).

Phthalocyanine derivative as an antimicrobial agent against periodontitis-related multispecies biofilms.

The activity of iron tetracarboxyphthalocyanine (FeTcPc) was investigated in the formation of subgingival biofilm by bacterial species associated with periodontal disease. A multispecies biofilm model was developed using the Calgary biofilm device and incubated at 37 °C under anaerobic conditions for 7 days. Starting from day 3, the biofilm was treated with FeTcPc twice daily for one minute over four days, at concentrations ranging from 1,000 to 10,000 μM.

Pulsed electromagnetic field therapy on nonsurgical treatment of peri-implantitis: 12-26 months follow-up.

Background: Pulsed electromagnetic field (PEMF) therapy, renowned for its immunomodulatory effects and established efficacy in orthopedics, shows promise for managing peri-implantitis by reducing soft tissue inflammation and marginal bone loss. This study aimed to compare the long-term clinical and radiographic outcomes of nonsurgical peri-implantitis treatment with and without PEMF therapy. This multicenter retrospective-prospective analysis combined data from two centers.

Phenotypic Screening of H-Antihistamines Identifies Promethazine and Rupatadine as Active Compounds Against Infective Larvae.

: Parasitic worm infections remain among the most prevalent and neglected health issues worldwide, affecting both humans and animals. Toxocariasis, caused by spp., is a widespread zoonosis with significant public health and economic implications.

Age-specific vulnerabilities in paediatric dental emergencies before, during, and after COVID-19 lockdown: a retrospective comparative analysis with emphasis on early childhood (0-3 years).

Purpose: To examine the unique vulnerability patterns of very young children (0-3 years) in dental emergencies before, during, and after the COVID-19 lockdown period, compared to older paediatric patients. The study aimed to identify age-specific risk factors and treatment needs that demonstrate increased susceptibility to severe dental emergencies during healthcare crises.

Methods: A retrospective analysis of 6,024 emergency dental visits of children under 12 years was conducted, comparing three periods: pre-COVID (March-May 2019), during the first lockdown (March-May 2020), and post-lockdown (March-May 2021).

Cubebin, a Lignan Isolated from , Exhibits Potent and Selective Antiparasitic Activity against.

is a zoonotic parasitic nematode of growing global health concern, largely due to the limited efficacy of current anthelmintics such as albendazole. In this study, cubebina dibenzylbutyrolactole lignanwas isolated for the first time from (Winteraceae), a Chilean endemic plant, and evaluated for its antiparasitic activity. Chromatographic purification of fresh leaves yielded cubebin as a 3:2 epimeric mixture, with its structure confirmed by 500 MHz NMR and single-crystal X-ray diffraction.

Surveying coating strategies for peri-implantitis management: Clinical implications and classificatory approaches.

Background: Peri-implantitis, an inflammatory condition occurring in the supportive tissues, is triggered by a dysbiotic biofilm that grows on implant and/or abutment surfaces. Consequently, the entire surface becomes a notorious culprit, fostering bacterial adhesion that might lead to progressive loss of supporting bone. To combat peri-implantitis, research groups worldwide have diligently pursued the development of new antimicrobial coatings.

Antibacterial activity of a bioactive composite resins containing surface pre-reacted glass in a complex multispecies subgingival biofilm.

This study evaluated the antibacterial activity of three S-PRG composite resins on the microbial profile of subgingival multispecies biofilm. A 96-well cell plate was employed to cultivate a 39-species biofilm associated with periodontitis over 7 days. Cylindrical specimens with 2 mm high and 2 mm diameters were prepared of each bioactive tested group (Beautifil II, Beautifil LS, Beautifil Bulk-Shofu) and for a control non-bioactive group (Z350 XT-3M ESPE).

Enhanced collagenogenesis on three-dimensionally printed titanium surfaces by human gingival fibroblasts: An in vitro study.

The lack of cementum in peri-implant tissues leads to a deficiency in anchorage points for gingival collagen fibers. This arrangement is linked to reduced protective capabilities compared to teeth. Therefore, there is a pressing need to develop surfaces that optimize the interaction between soft tissue and implants.

Treatment patterns and clinical interventions in pediatric dental emergencies during COVID-19.

Background: While COVID-19’s impact on dental services has been widely studied, limited research exists on how the pandemic altered clinical decision-making and treatment selection in pediatric dental emergencies. This study examined changes in treatment patterns and clinical interventions for pediatric dental emergencies during the COVID-19 lockdown, aiming to understand how crisis conditions influence clinical approaches and treatment outcomes.

Methods: This retrospective study analyzed 6,024 emergency dental visits of children under 12 years across three distinct periods: pre-COVID (March-May 2019), during first lockdown (March-May 2020), and post-lockdown (March-May 2021).

Artificial Intelligence and Dentomaxillofacial Radiology Education: Innovations and Perspectives.

Artificial intelligence (AI) is transforming dentomaxillofacial radiology education by enabling adaptive, personalized, and data-driven learning experiences. This review critically examines the pedagogical potential of AI within dental curricula, focusing on its ability to enhance student engagement, improve diagnostic competencies, and streamline clinical decision-making processes. Key innovations include real-time feedback systems, AI-guided simulations, automated assessments, and clinical decision support tools.

3D-Printed Rehabilitation and Immediate Loading in a Completely Edentulous Patient With Computed Guided Surgery: A Case Report With a 24-Month Follow-Up.

Implant-supported fixed rehabilitations are a reliable solution to restore aesthetics and function to edentulous patients. Currently, practitioners can use digital flow with computer-aided design & computer-aided manufacturing (CAD/CAM) technology to enhance their productivity by reducing working time and providing more comfort to patients. This report presents a clinical case in which the digital flow was used to restore the inferior edentulous arch in a 55-year-old female patient with an implant-based Misch's FP3 denture.

Effect of smoking over one pack daily on implant healing and health: A cohort study.

Background: This prospective cohort trial examines the effects of heavy smoking on peri-implant marginal bone loss (MBL) and implant survival rates over 15 months.

Methods: Thirty subjects, categorized as either smokers (more than 20 cigarettes daily for over 5 years) or non-smokers, were initially recruited with pocket depths ≤ 5 mm and at least one missing tooth. Urine cotinine assay was used to confirm smoking status.

Exploring the Antimicrobial Potential of a Peptide Against Mixed Biofilm of Staphylococcus aureus and Candida albicans.

Candida albicans and Staphylococcus aureus species are, respectively, the most common fungal and bacterial agents isolated from bloodstream infections worldwide. In addition, 20% of all C. albicans bloodstream infections have been shown to be polymicrobial in nature, and the bacterium Staphylococcus aureus is the third most common co-isolated organism.

Can combination syndrome influence functional performance and peri-implant bone remodeling in mandibular overdenture users? Results from a 5-year cohort study.

Purpose: This longitudinal clinical study aimed to investigate the circumferential peri‑implant bone level (CPBL), posterior mandibular resorption (PMR), and masticatory function (MF) in users of implant-retained mandibular overdentures (IMOs), comparing individuals with and without combination syndrome (CS) over a 5-year follow-up period.

Materials And Methods: A total of 39 patients were enrolled and stratified into two groups: absence of CS (ACS; n = 23) and presence of CS (PCS; n = 16). Assessments were conducted at 1, 3, and 5 years.

Skin Protection With Hydrofibre Foam and Silicone-Based Dressing Can Help Prevent Pressure Injuries: A Preliminary Evaluation in Brazil.

Understanding skin microclimate-the temperature and humidity at the interface between the skin and other surfaces-is critical for preventing pressure injury (PI). This prospective case series evaluated the performance of a hydrofibre multilayer foam dressing with silicone coating in managing the sacral microclimate in intensive care patients with intact skin at high PI risk when used with a standard PI prevention protocol. Sacral temperature and humidity were measured using a thermographic imaging camera and electrical bioimpedance device, respectively.

Clear orthodontic aligners in patients with a history of severe periodontitis: Two case reports with 12 months of follow-up.

Background: The orthodontic treatment of patients with a history of severe periodontitis helps to improve periodontal health, functional occlusion, and esthetics. The use of aligners in patients with a history of severe periodontitis, with a single protocol of periodontal treatment, and the report of periodontal parameters throughout the orthodontic treatment has not yet been evidenced. Therefore, this manuscript aimed to describe the treatment with a clear orthodontic aligner system in two patients with reduced periodontium associated with a history of severe periodontitis.

Improving TMJ MRI diagnostics in juvenile idiopathic arthritis: a comparative evaluation of image enhancement filters.

Objectives: To assess the effectiveness of two enhancement filters for magnetic resonance images of temporomandibular joint (TMJ) in patients with juvenile idiopathic arthritis (JIA).

Material: Magnetic resonance image (MRI) of 44 patients with JIA (15 males and 29 females) was analysed using OnDemand 3D software. Two experienced evaluators who were previously calibrated and blinded to the images assessed them subjectively regarding the use of Sharpen 1 and Sharpen 2 filters.

Brazilian Organic Honeydew Reduces In Vitro and In Vivo Periodontal Disease-Related Subgingival Biofilm.

We investigated the antimicrobial properties and effects on bone resorption of Brazilian organic honeydew (OHD) from the Bracatinga tree ( Benth.), a rare honey certified with Denomination of Origin, using a periodontal disease model. Antibiofilm activity was assessed using a subgingival biofilm adhered to the Calgary device.

Investigating the Clinical Merit of Contraction Patterns for Glabellar Neuromodulator Injections-A Clinical Retrospective Investigation Following the 3-Point Glabellar Injection Technique.

Background: Since the introduction of glabellar contraction patterns as a guide for neuromodulator treatments, feedback regarding its clinical utility has been mixed. Recent studies have cast doubt on the value of such contraction-pattern-driven treatment paradigms.

Objective: The aim of this retrospective study is to evaluate the clinical outcome of identical glabellar injections independent of glabellar contraction pattern types.

Brazilian red propolis as a potential antimicrobial additive in orthodontic primers.

This study evaluated the effect of adding ethanolic extract of red propolis (EERP) on antimicrobial activity, polymerization kinetics (PK), degree of conversion (DC), and shear bond strength (SBS) of the orthodontic adhesive system. Transbond XT Primer was the control group (G1). The experimental adhesives contained 3.