Acute effects of sport-related concussion among adolescents with a self-reported history of treatment for anxiety or depression.

This study compared symptom reporting and cognitive test performance within 72 h of a suspected concussion between high school student-athletes with and without pre-injury self-reported mental health treatment. Eight hundred seventy-nine high school athletes with ( = 75) and without ( = 804) a self-reported history of treatment for anxiety or depression underwent preseason baseline testing, and post-injury testing within 72 h of suspected concussion. At baseline, adolescents with a self-reported history of treatment for anxiety or depression ( = 75, 8.

Mapping spatiotemporal variability of wet season surface water processes in the Cuvelai-Etosha Basin, Namibia using stable isotopes.

The natural tracers δO and δH are essential for tracing hydrological processes by identifying water sources, tracking evaporation loss and floodwater dynamics to enhance water management and flood mitigation strategies. This study employed this approach in the ephemeral, endorheic Cuvelai-Etosha Basin (CEB), spanning northern Namibia and southern Angola, to determine its viability in capturing spatial and temporal hydrological patterns, their timing and interactions during a medium flood condition (2017), and contrasted with a drought year (2014). During the 2017 wet season 219 grab surface water samples were collected from ephemeral waterbodies in four sampling campaigns (February, March, April and May) in addition to a single campaign in May 2014 (63 samples).

Ambivalent Agents: The Social Mobility Industry and Civil Society Under Neoliberalism in England.

This article examines civil society organisations working to enhance social mobility in England, especially through higher education. Against the backdrop of neoliberal governance, we investigate whether these organisations operate as protective counter-movements resisting marketisation or as institutional mechanisms that stabilise the inequalities they aim to address. Drawing on Karl Polanyi's concept of the 'double movement' and Nancy Fraser's critique of marketised social protections, we map and analyse over 100 charities and non-profits established since 1992.

INDIGO randomised controlled digital clinical trial: INvestigating DIgital outcomes and quality of life in cancer survivors - a study protocol.

Introduction: There are estimated to be 3.4 million patients in the UK living after a diagnosis of cancer. We know very little about their quality of life or healthcare usage.

Randomized clinical efficacy and safety study of peltopepimut-S plus cemiplimab compared to cemiplimab alone in patients with recurrent/metastatic HPV16-positive head and neck cancer.

Background: Peltopepimut-S is a therapeutic vaccine, which induces specific expansion of both CD4+helper and CD8+cytotoxic T-cells against human papillomavirus type 16 (HPV16) E6/E7 oncoproteins.

Patients And Methods: In a randomized phase 2 trial, we evaluated the efficacy and safety of peltopepimut-S plus cemiplimab compared with cemiplimab alone as first-line or second-line therapy in recurrent/metastatic HPV16-positive head and neck cancer. The primary efficacy endpoint was the objective response rate (ORR) by an independent review (Response Evaluation Criteria in Solid Tumors version 1.

Management of chronic venous insufficiency in older adults.

Chronic venous insufficiency (CVI) develops as a consequence of valvular incompetence or venous obstruction over time and can significantly impair quality of life. Its prevalence and burden are highest among older adults, as the physiological changes of aging predispose to the onset and progression of CVI. We present an overview of the evaluation and management of CVI in older adults, with a focus on superficial venous disease.

A vaccine emergency-when to overrule parental refusal of vaccination at birth for prevention of vertical transmission of hepatitis B virus?

Hepatitis B virus (HBV) is a potentially chronic infection that can be transmitted from mother to child with the risk of developing cirrhosis, liver failure and hepatocellular carcinoma. There is a safe and effective vaccine to prevent vertical transmission that is recommended to be given as soon as possible after birth and within 24 hours.When a woman with HBV refuses the birth dose of HBV vaccine for her baby, infectious diseases and safeguarding teams are asked to provide urgent opinions on whether this crosses the threshold for triggering child protection mechanisms.

Clinical predictors and prognostic impact of left ventricular thrombus recurrence.

Background: There is limited contemporary data available on the subject of left ventricular thrombus (LVT) recurrence. This study aimed to evaluate the incidence, outcomes and predictors of patients with LVT recurrence after resolution.

Methods: This was a retrospective cohort study involving 346 patients with resolved LVT at baseline, derived from an echocardiography database at a tertiary medical centre, from March 2011 to January 2021.

Identifying physical health concerns of people with a mental health condition: an RCT.

Introduction: PhysiCards© have been co-designed to support an interactive, person-led approach to help people with mental health conditions identify and respond to cardiovascular disease (CVD) and other physical health concerns. This study aimed to test the efficacy of the PhysiCards© in assisting people accessing support from a mental health community managed organisation to identify and take action to address CVD and other physical health concerns.

Study Design: Parallel-group randomised controlled trial.

Randomized Sham Controlled Trial of Targeted Lung Denervation in Patients with COPD (AIRFLOW-3).

Rationale: AIRFLOW-3 was a 1:1 randomized, double blind, sham controlled trial of the d'Nerva Targeted Lung Denervation (TLD) System in patients with COPD.

Objective: Evaluate the impact of TLD on COPD exacerbations compared to optimal medical treatment.

Methods: AIRFLOW-3 patients were symptomatic (CAT ≥10) with moderate to very severe airflow obstruction (25% ≤ FEV ≤ 80% predicted) and GOLD E status (≥2 moderate or ≥1 severe exacerbation over prior 12 months).

Effect of C-reactive protein and serum amyloid A point-of-care testing on antibiotic prescribing for acute respiratory-tract infections at village clinics in China: A study protocol for a cluster randomised controlled trial.

Background: Antimicrobial resistance is a globally recognised public health threat. In rural China, antibiotic use is common for acute respiratory infections (ARIs), which include symptoms such as coughing and fever that are most likely viral infections but with a small proportion as bacterial infections. This study aims to evaluate the effectiveness of a comprehensive intervention based on C-reactive protein and serum amyloid A point-of-care testing (CRP&SAA POCT) in reducing the inappropriate use of antibiotics for ARIs in Chinese village clinics.

Modern Trends in Hospital-based Cosmetic Surgery Utilization Across Racial and Ethnic Groups.

Background: Historically, cosmetic surgery has been primarily utilized by White patients. However, in recent decades, the population in the United States has become increasingly diversified. It is unknown how these national demographic changes have affected the racial and ethnic distribution of those utilizing cosmetic surgical services.

Elinzanetant for the Treatment of Vasomotor Symptoms Associated With Menopause: A Phase 3 Randomized Clinical Trial.

Importance: There is an unmet need for long-term, safe, effective, and hormone-free treatments for menopausal symptoms, including vasomotor symptoms (VMS) and sleep disturbances.

Objective: To evaluate the 52-week efficacy and safety of elinzanetant, a dual neurokinin-targeted therapy, for treating moderate to severe VMS associated with menopause.

Design, Setting, And Participants: OASIS-3 was a double-blind, placebo-controlled, randomized phase 3 clinical trial that was conducted at 83 sites in North America and Europe from August 27, 2021, to February 12, 2024, and included postmenopausal women aged 40 to 65 years who were seeking treatment for moderate to severe VMS (no requirement for a minimum number of VMS events per week).

Innovative Dual Catheter Irrigation Technique for Clot Retention in a Hospice Setting: A Case Report.

Clot retention can be challenging to manage in a hospice setting in the final days, especially if a blocked urethral catheter cannot be replaced. Small-bore suprapubic irrigation using equipment commonly available in hospices can provide symptom relief without the need to transfer to acute settings.

I am a Behavior Analyst and an Advocate for ABA: Are you?

Behavior analysis and applied behavior analysis (ABA) have had many opponents since their inception. These opponents present challenges to the understanding and acceptance of our perspective and our professional practice. Asserting that behavior is a product of environmental circumstances is in opposition to our everyday language understanding of the cause of a person's behavior in that their behavior is determined not autonomous.

The immeasurable value of plankton to humanity.

Plankton, a diverse group of aquatic organisms, make Earth livable, regulate aquatic life, and provide benefits to human societies such as access to clean water, food security, and well-being. They also support economies and inspire biotechnological innovations. This article aims to raise awareness of the value of plankton to humanity and serves as an informative guide for aquatic professionals, policymakers, and anyone interested in plankton.

Do turtles get cancer?

Turtles are renowned for their extreme longevity and tremendous range in body size. Theoretically, large, long-lived organisms should face higher cancer risks because of increased cell numbers and lifetime cellular turnover, yet cancer appears to be exceptionally rare in turtles. In the present article, we synthesize the current knowledge on cancer prevalence in turtles, drawing from zoo necropsies, pathology reports, and comparative oncology studies, and present new data spanning additional species that reinforce this pattern.

Rare variant genetic landscape of familial chylomicronemia syndrome (FCS) in the United Kingdom.

Purpose: Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder. This study aimed to analyze the genotype distribution of FCS-causing genes in the United Kingdom.

Methods: Data were anonymously collated from 2 genetic testing laboratories providing national genetic diagnosis services for severe hypertriglyceridemia in the United Kingdom.

Digital-Based Nutrition Interventions Employing the Dietary Approaches to Stop Hypertension (DASH) Diet: A Systematic Scoping Review.

The Dietary Approaches to Stop Hypertension (DASH) diet is an internationally recognized anti-hypertensive dietary model. This systematic scoping review examines the effectiveness of digital-based interventions utilizing the DASH dietary pattern. A search was conducted using 14 databases to include relevant studies from 1997 to January 2025 using PRISMA guidelines for scoping reviews.

Pragmatic Comparative Effectiveness Trials in Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Multiperspective Qualitative Study.

Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) portends a devastating prognosis for patients, with survival typically being < 5 to 8 years after diagnosis. Limited clinical trial data exist to guide treatment strategies, and the efficacy of current strategies-immunomodulation and antifibrotics-remains uncertain. Large randomized controlled trials are costly, but pragmatic trial designs could reduce expenses.

Evaluation of outcomes for patients with nitrous oxide-related myeloneuropathy treated with self-injection of hydroxocobalamin versus nurse-led injections on an ambulatory care pathway.

Background: Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular (IM) hydroxocobalamin. This service development project evaluated a self-injection programme (SIP) compared with a nurse-led approach, within an established ambulatory care pathway, with the aim of improving treatment adherence and completion.

Motivational factors influencing radiography students' career choices: A survey study.

Background: Despite significant advancements in healthcare in the United Arab Emirates (UAE), limited research has explored the motivational factors influencing UAE radiography students' choice of this field.

Materials And Methods: Institutional using a cross-sectional survey, to explore motivational factors influencing career decisions among UAE radiography students. It was conducted in 2023 and involved 100 students from four universities across the UAE.

Strategy-based cognitive rehabilitation for childhood brain tumour: Protocol for an acceptability and feasibility trial of the Fatigue, Learning, and Memory Enrichment (FLaME) intervention.

Background: Medical treatments have improved survival rates for paediatric brain tumour (PBT), but the condition and treatment continue to be associated with significant cognitive morbidity. Nearly all survivors will experience some degree of cognitive impairment (neurocognitive 'late effects') that has a cascading impact on the development of intellectual and academic skills, quality of life, mental health, vocational attainment, and functional independence. Longstanding cognitive fatigue is also a prevalent symptom for survivors of PBT and further impacts engagement with therapeutic interventions and quality of life.

Examining for race-associated differences on Sway Medical System balance and cognitive tests used for sport-related concussion.

Background: Race associated differences and disparities in test scores, such as on neuropsychological measures, can complicate the interpretation of these test scores in student athletes following a concussion. It is unknown if there are race associated differences on the Sway Medical System, a battery that includes balance and cognitive tests for use in concussion management.

Purpose: To determine if there are race-associated differences in Sway Medical System balance and cognitive module scores among athletes undergoing preseason baseline testing.

The genome sequence of the Bordered Sallow moth, (Hufnagel, 1766).

We present a genome assembly from a female specimen of (Bordered Sallow; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence has a total length of 433.58 megabases.