A fuzzy-optimized hybrid ensemble model for yield prediction in maize-soybean intercropping system.

Maize-soybean intercropping is a sustainable farming practice that optimizes resource use efficiency and improves yield potential. Accurate yield prediction is essential for effective agricultural management in such systems. This study proposes a Fuzzy-Optimized Hybrid Ensemble Model (FOHEM), integrating stacked ensemble machine learning algorithms with a fuzzy inference system (FIS) to improve yield prediction.

Long non-coding RNAs PCAT-1 and FENDRR: diagnostic and prognostic potential in papillary thyroid carcinoma.

Background: Thyroid cancer is the most prevalent endocrine cancer worldwide. Certain histological subtypes of papillary thyroid carcinoma (PTC) exhibit aggressive behavior, with poor clinical outcomes. Long non-coding RNAs (lncRNAs) have emerged as critical regulators of various biological processes, making them promising candidates for cancer biomarkers.

An enhanced adaptive dynamic metaheuristic optimization algorithm for rainfall prediction depends on long short-term memory.

Sorting and analyzing different types of rainfall according to their intensity, duration, distribution, and associated meteorological circumstances is the process of rainfall prediction. Understanding rainfall patterns and predictions is crucial for various applications, such as climate studies, weather forecasting, agriculture, and water resource management. Making educated decisions about things like agricultural planning, effective use of water resources, precise weather forecasting, and a greater comprehension of climate-related phenomena is made more accessible when many components of rainfall are analyzed.

The ameliorative effect of gallic acid and/or Lasix on topiramate-induced renal impairment in male rats.

Background: Topiramate (TPM) is commonly used for migraine prophylaxis; nonetheless, it is linked to nephrotoxicity, which mostly results from oxidative stress and inflammatory mechanisms.

Aim: This study aimed to assess the preventive effects of gallic acid (GA) and furosemide (Lasix) against renal damage caused by TPM in rats.

Methods: Sixty male albino rats were categorized into six groups: control, TPM-only, TPM + Lasix, Lasix-only, TPM + GA, and GA-only.

Unveiling the therapeutic potential of anthocyanins in reserpine-induced fibromyalgia: A multi-dimensional study on behavioral, molecular, and pathological changes.

Fibromyalgia (FM) is a chronic syndrome, associated with unidentified musculoskeletal pain, depression, neuropathic pain, memory impairment, and chronic fatigue. As a natural therapy with minimal risk, the multi-therapeutic benefits of Anthocyanins (ANs) are unfolded. This study evaluates efficacy of two doses of ANs, compared to a common treatment for FM; Neurontin (Neu), against reserpine (Res)-induced FM-associated biochemical, molecular and behavioral alterations in rats.

Omarigliptin ameliorates cisplatin-induced renal damage: Cross-talk between glucagon-like peptide-1, HMGB1/RAGE/TLR4 signaling, and TXNIP/NLRP3 inflammasome/gasdermin D axis.

Background And Objectives: Cisplatin is a platinum compound that is effective in the management of neoplastic conditions including testicular, ovarian, and lung malignancies. However, the possible incidence of kidney damage may significantly affect its therapeutic value. Omarigliptin is a dipeptidyl peptidase-4 inhibitor that is effective in treatment of type 2 diabetes mellitus.

Efficacy of dietary Ceratonia silique and Zingiber offcinale on the immune-antioxidant-signaling pathways, growth, physiological response, and ammonia resistance in Oreochromis niloticus reared under unchanged water.

Prioritizing water management and maintaining its quality for as long as possible, while lowering related stressors, are crucial for sustainable aquaculture. To achieve this equilibrium, enriched aquafeed with natural immunostimulants is essential to success. In this trend, 6 weeks feeding trial was conducted to evaluate the effects of Ceratonia siliqua syrup (CSS) and Zingiber officinale powder (ZOP) in Nile tilapia (Oreochromis niloticus) reared under a zero-water exchange.

Fracture resistance of molars with class II MOD cavities restored with bulk-fill, no-cap flowable bulk-fill, and conventional resin composite restorative systems after 6-months water storage.

Background: Bulk-fill resin composites are innovative materials, developed to simplify the placement of direct composite restorations especially in large cavities. Recently, a new class of flowable bulk-fill resin composite is claimed to be placed without final capping layer. Thus, this study aimed to assess and compare the fracture resistance of molars with Class II MOD cavities restored with different types of resin composite restorative systems after 6-month water storage.

Short term effectevness of tibial nerve flossing technique in patients With tarsal tunnel syndrome.

ObjectiveTo examine the short-term influence of adding tibial nerve flossing (TNF) technique to conventional therapy on foot pain, Dorsiflexion-Eversion (DF-E) test, ankle range of motion (ROM), and tibial nerve conduction study (NCS) in individuals with Tarsal Tunnel Syndrome (TTS).MethodsThis was a parallel randomized pre-post-test single blinded controlled trial, included 54 individuals with TTS randomized into study and control groups. Both groups received conventional therapy including transcutaneous electrical nerve stimulation (TENS), therapeutic ultrasound (US), gastrocnemius (GC) muscle stretching, and foot arches supports/wedges provided as needed with an additional (TNF) technique provided for the study group.

A dual GAN with identity blocks and pancreas-inspired loss for renewable energy optimization.

Integrating energy and solar imagery is essential for electrical engineers in renewable energy prediction, consumption analysis, regression modeling, and fault detection applications. A significant challenge in these areas is the limited availability of high-quality datasets, which can hinder the accuracy of the predictive models. To address this issue, this paper proposes leveraging Generative Adversarial Networks (GANs) to generate synthetic samples for training.

Verapamil inhibits TXNIP-dependent NLRP3 Inflammasome activation in an ulcerative colitis rat model: A new evolving role of the calcium channel blocker.

Ulcerative colitis (UC) is a long-term inflammatory bowel disease (IBD) associated with significant morbidity. It is marked by inflammation and damage to the colon's mucosal lining. Studies have shown that NLRP3 inflammasome activation, apoptosis, and impaired autophagy are critical in its pathogenesis.

Experimental verification of Myriocin molecular bioactivity in revoking rheumatoid arthritis: New emphasis on S100A1 repression and PPAR-γ activation via non-canonical pathways in the flare-up of cytokines.

Myriocin (MYR), the immunosuppressive agent isolated from Mycelia sterilia is recently nominated as a potential therapy for various inflammatory disorders. This work is a primary insight on the mechanistic pathways for its potential anti-arthritic effect against complete Freund's adjuvant-induced arthritis in mice. First day double injection of 0.

Impact of dental pulp cells-derived small extracellular vesicles on the properties and behavior of dental pulp cells: an in-vitro study.

Background: Dental pulp cells-derived small extracellular vesicles (DPCs-sEVs) had shown immunomodulatory, anti-inflammatory, and tissue function restorative abilities. Therefore, DPCs-sEVs should be considered as a promising regenerative tool for dentin-pulp complex or whole pulp regeneration. This study aimed to evaluate the effect of DPCs-sEVs on the proliferation rate, migration capability, and expression pattern of DPCs for osteo/odontogenic gene markers in comparison with mineral trioxide aggregate (MTA).

The combined effect of biofeedback training and osteopathic procedures for the treatment of functional daytime urinary incontinence: A prospective, randomized clinical trial.

Background: Functional daytime urinary incontinence (FDTUI) is characterized by involuntary urine leakage during the day. This prospective, randomized clinical trial investigated the effectiveness of combined biofeedback training and osteopathic procedures in treating FDTUI.

Methods: The study involved 117 randomly assigned to three groups: group A received combined therapy of biofeedback training, osteopathy techniques, and behavioural modifications; Group B received biofeedback training and behavioural modifications, while Group C received osteopathy techniques and behavioural modifications.

A reversible and robust hybrid image steganography framework using radon transform and integer lifting wavelet transform.

This study introduces a reliable and reversible image steganography framework that integrates Radon Transform (RT) and Integer Lifting Wavelet Transform (ILWT) to enhance security, imperceptibility, and robustness. The RT obscures data locations through rotations, scaling, and translations, while ILWT ensures full reversibility by maintaining integer wavelet coefficients, guaranteeing no data loss during reconstruction. Data embedding is performed in the middle bit planes of high-frequency sub-bands (LH, HL, HH) using Arithmetic Coding, optimizing space utilization while preserving visual quality.

Edaravone protects against cuprizone-induced demyelination in rats by modulating TNF-α/NF-ĸB/NLRP3 signaling and the kynurenine pathway.

Multiple sclerosis (MS) is a neurodegenerative disorder involving various pathways that affect disease progression and treatment. The kynurenine pathway (KP) has gained attention in MS studies, contributing to demyelination and disease progression. This study aimed to explore the pharmacological effects of edaravone (EDV) on the corpus callosum and the spinal cord in the cuprizone (CPZ) animal model of demyelination.

Anti-neoplastic activity of celastrol in experimentally-induced mammary adenocarcinoma in mice: targeting wnt/β-catenin signaling pathway.

Natural bioactive compounds with anti-neoplastic effects, such as celastrol (CLS), have attracted considerable interest in recent years. The present study aimed to investigate the effect of CLS on wnt/β-catenin signaling, and its potential combination with doxorubicin (Dox) to enhance chemotherapeutic effects. After intramuscular inoculation of Ehrlich tumor cells, tumor-bearing mice received CLS (2 mg/kg, i.

Effect of High-Intensity Focused Electromagnetic Therapy on Balance and Quality of Life in Elderly Type 2 Diabetic Men: A Randomized Controlled Trial.

Objective: To assess the effect of high-intensity focused electromagnetic therapy (HIFEMT) on balance, core strength, fall risk, and quality of life (QoL) in elderly men with type 2 diabetes.

Design: A prospective randomized controlled trial with a single-center focus.

Setting: This study was conducted at a private geriatric rehabilitation unit from April to December 2024.

Neutrophil percentage-to-albumin ratio as predictor for mortality in patients undergoing endoscopic intervention for variceal hemorrhage.

Background: Variceal bleeding (VB) is a serious condition that can lead to increased hospital costs and mortality rates. The neutrophil percentage-to-albumin ratio (NPAR) has been recognized as a predictor of mortality in various diseases. However, the use of NPAR as a predictor of hospital mortality in patients with VB has not been studied previously.

Protective effect of against experimental hepatic ischemia reperfusion injury downregulating oxidative stress, inflammation, and apoptosis.

Hepatic ischemia/reperfusion (Hep I/R) is a great health burden during hepatic transplantation surgery. The present work aimed to examine the mitigative effect of against Hep I/R and its underlying protective mechanisms. The animals in the present research were classified into four equal experimental groups (n=6): the sham group, sham+ group, Hep I/R group, and Hep I/R+ group.

Developing a Urinary Catheter with Anti-Biofilm Coated Surface Using Phyto-Assisted Synthesis of Zinc Oxide Nanoparticles.

Background: Biofilm-related infections represent one of the major challenging health problems that enhances antimicrobial resistance with subsequent treatment failure of catheter-associated urinary tract infections (CAUTIs).

Aim: This study aimed to employ and comprehensively characterize the use of nanoparticles to inhibit bacterial biofilm formation. Zinc oxide nanoparticles (ZnO-NPs) are considered one of the most important biofilm inhibitors.

Comparative clinical performance of stainless steel, zirconia, and Bioflx crowns in primary molars: a randomized controlled trial.

Background: Choosing the appropriate crown type for primary molars is essential for effective restoration and oral health. Stainless steel crowns are durable and cost-effective, making them suitable for extensive decay. Zirconia crowns offer esthetic advantages, while Bioflx crowns require less preparation and provide optimal appearance.

Effect of deep brain stimulation for lateral hypothalamic area on memory decline and hippocampal neurofilaments expression dysfunctions in aged rats.

Objective: Studying the effect of deep brain stimulation (DBS) in the lateral hypothalamic area (LHA) in young and aging rats regarding memory changes, hippocampal neuronal dystrophy, and neurofilament expression.

Methods: Thirty-six male Sprague-Dawley rats were divided into two main groups: adult young ( n  = 18, 8 weeks old) and aged ( n  = 18, 24 months old). Each main group was further subdivided into three equal subgroups ( n  = 6) including control, sham, and DBS.

Efficacy of adjuvant use of midodrine in patients with septic shock: An open label randomized controlled trial.

Background: Midodrine has been primarily studied as an adjunctive oral therapy to reduce the need for vasopressors in intensive care units (ICU). Nonetheless, the available results evaluating midodrine as an adjuvant therapy in the treatment of septic shock are limited and inconclusive. This study aims to evaluate the efficacy of midodrine, specifically focusing on its effect on mortality outcomes in patients with septic shock.

Neutrophil Percentage-to-Albumin Ratio as a Predictor of Acute Kidney Injury in Cirrhotic Patients: A Novel Approach Utilizing Artificial Intelligence.

Introduction: Acute kidney injury (AKI) is common in cirrhotic patients and is associated with a poor prognosis. The neutrophil percentage-to-albumin ratio (NAR) is a novel marker of systemic inflammation. This study aimed to evaluate the predictive power of NAR for AKI in cirrhotic patients with ascites using AI tools such as Shapley Additive Explanations and a Random Forest (RF) model.