Whole genome sequencing and comparative genome analysis of three multidrug resistant clinical uropathogenic Escherichia coli isolates from India.

Aim: To investigate the phenotypic and genomic features of three multidrug-resistant (MDR) clinical mucoid and non-mucoid uropathogenic Escherichia coli (UPEC) strains to understand their antimicrobial resistance, biofilm formation, and virulence in urinary tract infections (UTIs).

Methods And Results: The UPEC strains A5, A10, and A15 were isolated from two UTI patients. Phenotypic assays included colony morphology, antibiotic susceptibility, motility, and biofilm formation.

Transformative Therapies for Wound Care: Insights into Tissue Engineering and Regenerative Medicine.

Wound healing is a dynamic and complex process that consists of four interconnected phases: hemostasis, inflammation, proliferation, and remodeling. This complex process is based on the coordinated actions of growth factors, cytokines, and other cellular interactions. However, conditions such as diabetes and chronic illnesses can disrupt this process and lead to nonhealing wounds or chronic ulcers.

From slime to sublime: the impact of snail mucin on scar therapy and wound healing in dermatology.

Purpose Of The Article: Snail mucin (SM) has garnered significant attention in dermatology, particularly for its potential in scar therapy and wound healing, due to its bioactive compounds, like allantoin, glycolic acid, and hyaluronic acid. These compounds are known to promote tissue regeneration, enhance skin hydration, and reduce scarring.

Materials And Methods: However, despite growing interest, significant gaps remain in the clinical understanding of SM's therapeutic potential, including a lack of standardised formulations and limited clinical trials.

The Psychological Impact of Male Infertility: A Narrative Review.

Male infertility is a major health concern worldwide. While biological causes are well understood, the psychological aspects receive less focus. This gap is evident in clinical practice and research, where emotional, social, and mental health issues linked to male infertility are often neglected or inadequately managed.

Effect of Kinetic Control Training and McKenzie's Approach on Pain and Mobility in Cervical Derangement Syndrome: A Comparative Study.

Background: Cervical derangement syndrome (CDS), a form of mechanical neck pain, arises from poor posture, repetitive stress, and segmental dysfunction, resulting in discomfort, restricted cervical mobility, and reduced functional capacity. The study focuses on changes associated with CDS, particularly range of motion (ROM), pain, and functional disability. The study aims to find the effect of kinetic control training (KCT) and the McKenzie approach on CDS.

Correction: Osteo-inductive potential of homoeopathy potencies of Asafoetida on multipotent mesenchymal stem cells in vitro.

[This corrects the article DOI: 10.1007/s13205-025-04245-1.].

Effect of parental educational programs on knowledge and attitude regarding guidelines on screen time and digital wellness among parents of children under 10 years in a selected rural community Puducherry - A pre-experimental study.

Background: Screen - -based media have become an important part of human lifestyle. Striking a balance between the digital and physical world is crucial. Proactive stance toward digital wellbeing can create a future in which technology and wellbeing coexist together The primary aim of the study was to evaluate the effect of parental educational programs on knowledge and attitude regarding guidelines of screen time and digital wellness among parents of children under 10 years in a selected community area, Puducherry.

Knowledge, awareness and attitude of healthcare professionals toward the use of ChatGpt: A cross-sectional study.

Background: ChatGPT is increasingly finding its applicability in various aspects of life, including the healthcare system. However, its use is not so much prevalent as of now among healthcare professionals. The present study aimed to assess the knowledge, awareness, and attitude of healthcare professionals toward the use of ChatGPT.

Correction: Impact of Phacoemulsification on Trabeculectomy Bleb Function and Morphology in Primary Angle Closure Glaucoma: A Comparative Study of the Visco-Cushion Effect.

[This corrects the article DOI: 10.7759/cureus.70749.

The bio-transformation of green tea infusion with tannase enzymes produced by KMS2-2.

Unlabelled: Green tea is one of the most widely drunk beverages globally; It is made from the processed leaves of the green shrub . The background study focused on the contained catechins and their hydrolysis by tannase-producing KMS2-2 strains were investigated. Tannin acyl-hydrolase is an inducible enzyme extensively used in the food industry.

A Bird's-Eye View of the Wings Apart-Like Protein in Cell Biology and Implications for Disease and Therapeutics.

Wings apart-like protein (WAPL) has emerged as a key player in maintaining genome integrity through its regulation of cohesin dynamics, which govern chromatin architecture and gene expression. WAPL mainly acts as a cohesin release factor and ensures proper chromosomal segregation during mitosis by promoting sister chromatid resolution. Owing to its prominent role in cell biology, WAPL dysregulation can cause genomic instability and disrupt chromosomal cohesion, leading to diseases such as cancer.

Design, Development and Evaluation of Orally Disintegrating Mini-tablets (ODMTs) Containing Cefixime for Paediatric Use: A Novel Approach.

Objectives: The study aimed to combine instant-release and mini-tablet methodologies to develop novel orally disintegrating mini-tablets (ODMTs) for a frequently pescribed antibiotic, cefixime trihydrate (CT), in paediatric patients.

Materials And Methods: CT-loaded microcapsules were prepared using Eudragit EPO and Hydroxy Propyl Methyl Cellulose E50 by spray drying technique. The optimized microcapsules were mixed with co-processed ready-to-use tableting excipients, Ludiflash and Pearlitol 200SD, in different proportions and then compressed into ODMTs and evaluated.

Genome-wide identification and expression analysis of like genes in pearl millet under diverse biotic and abiotic stresses and phytohormone treatments.

Nonexpressor of pathogenesis-related genes 1 (NPR1) is a master regulator of salicylic acid (SA)- facilitated plant hormone signaling and plays a crucial role in plant defense through the activation of systemic acquired resistance (SAR). Although like genes are associated with stress responses in a variety of plant species, no thorough genome-wide investigation of these genes has been undertaken in pearl millet (). This study discovered seven -like genes on four pearl millet chromosomes (Chr1, Chr2, Chr4, and Chr6), which exhibit close affinity to NPRs from other plants and have common gene structures, conserved motifs, and domains.

Therapeutic potential of small peptides in Alzheimer's disease: Advances in memory restoration and targeted delivery systems.

Despite extensive research into Alzheimer's disease (AD), few therapeutic strategies have successfully addressed its core pathology at the synaptic level. Small peptides represent a promising class of therapeutic agents capable of modulating key molecular pathways involved in amyloid toxicity, tau hyperphosphorylation, and synaptic degeneration. Their unique ability to cross biological barriers, interact with intracellular targets, and be modified for enhanced stability positions them as viable candidates for next-generation treatments targeting cognitive decline in AD.

FoodABSANet: Developing an adaptive graph convolutional neural network for aspect-based sentiment analysis of food reviews with a weighted polarity score.

-Aspect-Based Sentiment Analysis (ABSA) is considered a unique variant, which intends to identify the opinions regarding delicate topics. However, it is a neglected topic of study, ABSA attempts to find out the sentiment polarity on particular characteristics within statements, enabling more precise mining of consumers' emotional polarities regarding various aspects. The conversion of the conventional rating-aided recommendation approach into an effective aspect-aided procedure is made easier by this evaluation.

Alterations in 3D Chromatin Spatial Organisation in Tumourigenesis and Therapy Resistance of Glioblastoma: The Recent Advances in Understanding Molecular Mechanisms, Clinical Implications, and Therapeutic Perspectives.

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of brain cancer, characterised by profound genetic, epigenetic, and phenotypic heterogeneity. Recent advancements in high-resolution genome mapping have unveiled the critical role of three-dimensional (3D) chromatin architecture-encompassing chromatin loops, topologically associating domains, and enhancer-promoter interactions-in driving GBM tumourigenesis and therapy resistance. This review summarises recent insights into the mechanistic contribution of 3D genome reorganisation in sustaining oncogenic transcriptional programs, promoting intratumoural heterogeneity, and facilitating adaptive resistance.

A comprehensive insight into NETosis-extracellular vesicle crosstalk in autoimmune diseases.

Neutrophils are granular and polymorphonuclear cells and one of the main participants of the innate immune system, which have received considerable attention due to the discovery of neutrophil extracellular traps (NETs). Extracellular vesicles (EVs), particularly those released by immune cells such as neutrophils, have been associated with the immunopathogenesis of autoimmune diseases. Besides, studies have reported a fundamental correlation between EVs and NETosis in autoimmune diseases.

Letter to the editor: "The recruitment of adolescents with obesity to a randomised controlled trial: A fast track to health sub-study".

We read with great interest the article by House et al. detailing recruitment strategies for the Fast Track to Health trial, which evaluated intermittent versus continuous energy restriction in adolescents with obesity and cardiometabolic complications [1]. The study provides valuable insight into recruitment yields across varied referral sources, highlighting the dominant role of specialist referrals (21.

Ultrasound pretreatment-enhanced OSA esterification of proso millet starch for application in low-fat mayonnaise.

Ultrasonication (US) pretreatment (10 and 20 min) before octenyl succinic anhydride (OSA, 3 %) esterification significantly increased the degree of substitution (DS) in proso millet starch, increasing it from 0.0078 to 0.0115.

Exploring the bioactive constituents from spices targeting N-methyl-d-aspartate receptors: An in silico and in vitro approach to identify druggable leads against neurological disability.

N-methyl-d-aspartate (NMDA) receptors are validated druggable targets for the treatment of Alzheimer's and other associated neurological conditions, particularly in individuals with disabilities. Considering the excitotoxicity associated with NMDA receptors, which leads to neuronal damage, cognitive impairment, and limitations of current therapeutic regimens, better therapeutic candidates are required. One of the validated drug discovery approaches is computer-assisted drug discovery, supplemented by molecular docking, mechanics, and dynamics.

2D-1D Self-Assembly of Water Delaminated Co-Fe-LDH Nanosheets and CNTs via Exfoliation-Restacking Approach for Efficient Oxygen Evolution Reaction.

Developing efficient, sustainable, earth-abundant, cost-effective electrocatalysts is extremely challenging. Cobalt-iron-layered double hydroxide nanosheets (Co-Fe-LDH NSs) hybridized with carbon nanotubes (CNTs) lead to anchors Co-Fe-LDH-CNTs (CFC) self-assembly with a mesoporous morphology, expanded surface area, fast charge transfer kinetics, and high electrical conductivity. The resultant anchored CFC nanohybrid is highly active for electrocatalytic oxygen evolution reaction (OER), showing a lower overpotential of 221 and 313 mV at a current density of 10 and 25 mA cm, respectively, compared to pristine Co-Fe-LDH (339 and 391 mV), showcasing the significant role of CNTs in improving the electrocatalytic performance of pristine Co-Fe-LDH.