In-Hospital Mortality in Children Undergoing Congenital Heart Surgery in North Brazil: A 9-Year Analysis From a Regional Referrel Center.

To analyze in-hospital mortality in children undergoing congenital heart interventions in the only public referral center in Amazonas, North Brazil, between 2014 and 2022. This retrospective cohort study included 1041 patients undergoing cardiac interventions for congenital heart disease, of whom 135 died during hospitalization. Records were reviewed to obtain demographic, clinical, and surgical data.

Biparametric vs Multiparametric MRI for Prostate Cancer Diagnosis: The PRIME Diagnostic Clinical Trial.

Importance: Multiparametric magnetic resonance imaging (MRI), with or without prostate biopsy, has become the standard of care for diagnosing clinically significant prostate cancer. Resource capacity limits widespread adoption. Biparametric MRI, which omits the gadolinium contrast sequence, is a shorter and cheaper alternative offering time-saving capacity gains for health systems globally.

Experiences and preferences for HIV prevention modalities among transgender women and sex workers in São Paulo, Brazil: a qualitative study.

Transgender women and sex workers in Brazil underutilise HIV prevention services. Understanding preferences and decision-making regarding HIV prevention can help develop new programmes to meet their needs. We conducted semi-structured interviews with 26 transgender women and travesti sex workers in São Paulo, Brazil.

Adsorptive behavior of multi-walled carbon nanotubes functionalized with iron nanoparticles for bisphenol A removal.

Bisphenol A (BPA) is a persistent organic pollutant with toxic effects on human health and ecosystems. In this study, the performance of MWCNT-OH functionalized with iron nanoparticles (MWCNT-OH@Fe) using sugarcane bagasse extract as a reducing agent (green synthesis) was evaluated for BPA adsorption. The kinetics are fast, between 10 and 20 min in the range of concentrations evaluated and the resistance to external film diffusion (external film mass transfer) identified as the rate-limiting step of the process.

Atypical "opened-bottle" proximal tibial fractures in young male patients with growth hormone and aromatase inhibitor treatment: case series.

Atypical proximal tibial fractures in adolescents are rare, particularly when linked to hormonal therapy for short stature. This case series reports the clinical and imaging features of atypical proximal tibial and distal femoral physeal fractures in male adolescents undergoing combined growth hormone (GH) and aromatase inhibitor (AI) therapy for idiopathic short stature. We report three cases of skeletally immature male adolescents (ages 12-16) treated with GH and anastrozole who presented with acute leg pain following low-energy trauma during soccer.

Intraoral vs. extraoral photobiomodulation therapy for oral mucositis in head and neck cancer patients: a multicenter, randomized, single-blind clinical trial.

Purpose: To compare the efficacy of intraoral (IOPBM) and extraoral photobiomodulation (EOPBM) protocols for the prevention and treatment of oral mucositis (OM) in patients with oral or oropharyngeal squamous cell carcinoma (SCC) to submitted radiotherapy (RT).

Methods: This randomized, blinded, multicenter clinical trial enrolled 58 patients with oral or oropharyngeal SCC, who were allocated into two groups matched by treatment type, clinical stage, and RT modality. Group I (IOPBM) received intraoral photobiomodulation (PBM) with a continuous InGaAlP diode laser (660 nm, 100 mW, 0.

Effects of 2 Training Protocols on Aspects of Pain in Older Women With Chronic Low Back Pain: A Randomized Clinical Trial.

Objective: The purpose of this study was to compare the effects of 16 weeks of functional versus dual-task training on aspects of pain in older women with chronic nonspecific low back pain.

Methods: This randomized clinical trial included 38 participants aged 60 to 79 years divided into 2 groups: functional training (FT) and dual-task training (DT). We assessed pressure pain threshold (PPT), temporal summation of pain, conditioned pain modulation (CPM), trunk instability, isometric strength, and endurance of trunk muscles before and 16 weeks after training.

First Transcatheter Pulmonary Valve Replacement in Tanzania: Feasibility of Advanced Cardiac Interventions in Resource-Limited Settings.

Background: Transcatheter pulmonary valve implantation (TPVI) has emerged as a viable alternative to surgical pulmonary valve replacement for patients with congenital heart disease and right ventricular outflow tract dysfunction. However, its adoption in low-resource settings has been limited.

Case Summary: We report the first successful TPVI procedures in Tanzania.

Manual therapy and exercise targeted to the neck and orofacial regions for patients with orofacial pain: a systematic review and meta-analysis.

Purpose: To summarize the evidence on the effectiveness of manual therapy (MT) and exercise targeted to the neck or jaw and neck (combined) in the management of orofacial pain (OFP).

Material And Methods: The protocol was registered in PROSPERO (CRD42021227490). Electronic searches were conducted in MEDLINE, EMBASE, Cochrane Library, Web of Science, SCOPUS, and CINAHL.

What is the influence of fatigue, ALSFRS-R scores, cognitive status, and pain in individuals with Amyotrophic Lateral Sclerosis? A cross-sectional study.

Fatigue remains a poorly understood symptom in individuals with ALS, and little is known about its associtation with other symptoms, including functional impairment, cognition, and pain. To identify the levels of fatigue, pain, ALSFRS-R, and cognition of a Brazilian group of individuals with ALS, in order to verify possible influences between these symptoms and fatigue. This is a cross-sectional study conducted with individuals with ALS who were recruited intentionally, using a non-probabilistic sampling method.

Bent Ab interno Needle Goniotomy versus Gonioscopy-Assisted Transluminal Trabeculotomy in Primary Open Angle Glaucoma: A Randomized Clinical Trial.

Prcis: Gonioscopy-Assisted Transluminal Trabeculotomy achieved a higher success rate than Bent Ab interno Needle Goniotomy in pseudophakic primary open angle glaucoma eyes at 12-months.

Purpose: To evaluate and compare efficacy and safety of standalone Bent Ab interno Needle Goniotomy (BANG) and Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in pseudophakic primary open angle glaucoma (POAG) eyes.

Methods: Parallel, double-arm, 1:1 ratio, single masked, single surgeon, randomized clinical trial.

The role of inhibitory neuronal variability in modulating phase diversity between coupled networks.

Neuronal heterogeneity, characterized by a multitude of spiking neuronal patterns, is a widespread phenomenon throughout the nervous system. In particular, the brain exhibits strong variability among inhibitory neurons. Despite the huge neuronal heterogeneity across brain regions, which in principle could decrease synchronization due to differences in intrinsic neuronal properties, cortical areas coherently oscillate during various cognitive tasks.

Economics trumps biology: Corcyra cephalonica as the optimal factitious host for cost-effective mass production of Chelonus bifoveolatus, a key parasitoid of Spodoptera frugiperda.

Background: The parasitoid Chelonus bifoveolatus is a promising biocontrol agent against the invasive fall armyworm (FAW) Spodoptera frugiperda, but its practical application hinges on cost-effective mass rearing. This study compares the biological performance and production economics of Ch. bifoveolatus reared on two factitious hosts (Corcyra cephalonica and Spodoptera litura) under controlled laboratory conditions.

Core-Level Photoelectron Angular Distributions from Bulk-Solvated to Surface-Active Aqueous Potassium Carboxylate Salts.

Photoelectron angular distributions are reported for a series of aqueous potassium carboxylate solutions, ranging from bulk-solvated to strongly surface-active species. The quantitative information determined from this work demonstrates how the measured photoelectron angular distributions are influenced by the ions' increasing propensity for the surface in aqueous solutions. Our study provides insight into the relative depth and location of the carboxylate functional group, which is valuable for investigating the adsorption of organic molecules at liquid-vapor interfaces.

A general and epidemiological overview of strongyloidiasis in Brazil.

Strongyloidiasis, caused by , is a neglected parasitic disease and a major global public health issue. This infection exhibits diverse clinical manifestations that, along with the high rates of asymptomatic cases and low-sensitivity diagnostic methods, contribute to the underreporting of the disease. With an estimated 600 million people infected worldwide, this disease is particularly prevalent in tropical and subtropical regions with poor sanitary conditions, which includes Brazil.

A New Family of Ternary Intermetallic Compounds with Dualistic Atomic Ordering - The ZIP Phases.

A new family of nanostructured ternary intermetallic compounds - named the ZIP phases - is introduced in this work. The ZIP phases exhibit dualistic atomic ordering, i.e.

Association between physician specialty and first-attempt intubation success in the emergency department.

Background And Importance: Emergency airway management in the emergency department (ED) is a high-risk procedure associated with patient outcomes. First-attempt success is a widely recognized quality metric, as multiple attempts are associated with an increased risk of peri-intubation complications. In Brazil, where emergency medicine is a recently established specialty, many ED are staffed by physicians without formal emergency medicine training.

Clinical, Radiographic and Histopathological Analysis of Cemento-Ossifying Fibromas and Fibro-Osseous Lesions of the Oral and Maxillofacial Region: A 53-Year Retrospective Study and Update of Current Concepts.

Background: Fibro-osseous lesions (FOL) of the jawbones and cemento-ossifying fibroma (COF) represent a heterogeneous group of lesions with overlapping histopathological features and variability in biological behavior. Thus, this study aimed to evaluate the clinical, radiographic, and histopathological characteristics of FOLs (cemento-osseous dysplasia-COD, fibrous dysplasia-FD, ossifying fibroma-OF) as well as COF, diagnosed at a reference center in oral pathology over 53 years.

Methods: Sex, age, symptoms, clinical diagnosis, time of evolution, anatomical site, size of the lesion, and radiographic characteristics were collected from all cases of lesions previously diagnosed as FOLs.

Sex-Related Differences in Histone Acetylation and Tumor Development in a 4-Nitroquinoline 1-Oxide and Ethanol-Induced Oral Squamous Cell Carcinoma Mouse Model.

Background: Oral squamous cell carcinoma (OSCC) is one of the most frequent head and neck cancers. The 4-nitroquinoline 1-oxide (4NQO) mouse model of oral carcinogenesis is a well-established model to investigate the mechanism behind OSCC development, including epigenetic alterations. Studies have shown that histone acetylation is a key regulator of gene expression and may play a role in such a tumor.

Models of care for children and adolescents with type 1 diabetes in low- and middle-income countries: a scoping review.

Background: In order to improve the outcomes of children and adolescents with type 1 diabetes mellitus (T1DM), access to and quality of comprehensive acute and chronic care services in low- and middle-income countries (LMIC) must be improved.

Objectives: To identify and summarise the characteristics of models of care for T1DM in children and adolescents in LMIC.

Search Methods: We searched MEDLINE, Scopus, the Cochrane Central Register of Controlled Trials (CENTRAL), and the World Health Organization (WHO) Global Index Medicus from inception to 11 December 2023 without restrictions.

Multiyear Drought Strengthens Positive and Negative Functional Diversity Effects on Tree Growth Response.

Mixed-species forests are proposed to enhance tree resistance and resilience to drought. However, growing evidence shows that tree species richness does not consistently improve tree growth responses to drought. The underlying mechanisms remain uncertain, especially under unprecedented multiyear droughts.

Deep Vein Thrombosis in Critically Ill Patients with COVID-19 Pneumonia: Incidence, Wells Score Diagnostic Performance, and Hospital Prognosis.

Objectives: The risk of major venous thromboembolism (VTE) among patients with COVID-19 is high but varies with disease severity. Estimate the incidence of lower extremity deep venous thrombosis (DVT) in critically ill hospitalized patients with COVID-19, validate the Wells score for DVT diagnosis, and determine patients' prognosis.

Methods: This was an observational follow-up study in the context of the diagnosis and prognosis of DVT.

Surgical outcomes from haematoma evacuation for intracerebral haemorrhage in the INTERACT3 study.

Background: There is ongoing controversy as to whether surgical intervention to haematoma evacuation benefits patients with acute intracerebral haemorrhage (ICH). This study aimed to evaluate the association of surgical intervention to evacuate the haematoma and 6-month functional outcome in participants of the third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3).

Methods: This was a secondary analysis of INTERACT3, which enrolled adults (age ≥18 years) spontaneous ICH patients within 6 h after onset.