Multicomponent oleogels of ethylcellulose-binary waxes: atomic force microscopy observation and synergistic effect analysis.

The interactions between ethylcellulose (EC) and waxes in multicomponent oleogel systems are underexplored. This study investigated the structural, functional, and physiochemical properties of rice bran oil (RBO) oleogels structured with various ratios of EC and a binary wax blend (9:1 beeswax (BW): carnauba wax (CRW)), varied in 0.5 % w/w increments at a constant total gelator concentration of 4 % w/w.

Comparative Analysis Methodologies in Nursing Research: A Scoping Review.

Background: Being a global profession, having evolved differently across different geographical areas, and with increasing global migration, nursing is well positioned to undertake comparative research to facilitate understanding and identify areas for development. Despite this, little is known about comparative research use in nursing, and there is little guidance for researchers on how to approach it. With increasingly sophisticated approaches, there is a need to understand how comparative analysis is currently being used.

Efficacy and welfare effects of different forms of physical restraint for upper airway endoscopy of horses.

Background: Physical restraint of horses for veterinary procedures is necessary to allow completion of tasks effectively and without injury to patient or personnel.

Objectives: To compare physiological effects and behavioural responses to four commonly used restraint techniques for upper respiratory tract (URT) endoscopy in unsedated horses.

Study Design: Blocked and randomised interventional study.

Highlights from the Manifesto on the Health Economics of Cardiovascular Disease Prevention.

Cardiovascular disease (CVD) is a major contributor to the health and economic burden of disease globally. In this paper we discuss the literature on the health economics of the prevention and early intervention in CVD. We reveal the large economic impact of CVD and provide the economic argument supporting the calls for early detection and diagnosis of CVD outlined in the Global Heart Hub's patient-led Manifesto for Change.

Confronting Violence: Advocacy Challenges and Community Development Strategies Against Corrective Rape in South African Townships.

This article explores the multifaceted challenges and potential strategies for addressing corrective rape in South African townships. Corrective rape, a violent form of gender-based violence primarily targeting lesbian women, is entrenched in patriarchal norms, homophobia, and racialized backlash that complicate anti-rape advocacy. Through a critical review of existing literature, this study highlights how these intersecting forces hinder progress while also identifying opportunities for intervention.

An old leukaemia in young patients-Genetic characteristics of paediatric chronic myeloid leukaemia.

Chronic myeloid leukaemia (CML) accounts for 2% of leukaemias in children and 9% in adolescents. While the BCR::ABL1 fusion gene remains a hallmark across all age groups, emerging evidence suggests that paediatric CML exhibits unique biological and clinical characteristics compared to its adult counterpart. Children often present with more aggressive clinical features and show distinct treatment response patterns.

Partial D variant with demonstrated risk of D alloimmunization in the Australian Indigenous population.

Background And Objectives: Two prior publications have identified a novel RHD variant in the Australian population with the pattern of single nucleotide variation (SNV) c.186G>T, c.410C>T, c.

The effects of low-yield nicotine cigarette smoke inhalation on orthodontic tooth movement.

Objective: This study aimed to investigate the effects of low-nicotine cigarette smoke (CS) inhalation on orthodontic tooth movement (OTM) in rats.

Methods: Forty 4-week-old male Wistar rats, were randomly divided into four groups: three experimental and one control. Group 1 (control group) had dental impressions taken at week 9.

Evaluating the implementation of the Deadly Aboriginal and Torres Strait Islander Nursing and Midwifery Mentoring (DANMM) programme: a mixed-methods pilot study conducted across four Local Health Districts in New South Wales, Australia.

Objective: Cultural safety is critical to addressing healthcare disparities for Aboriginal and Torres Strait Islander peoples. The Deadly Aboriginal and Torres Strait Islander Nursing and Midwifery Mentoring (DANMM) programme was developed to support Aboriginal and Torres Strait Islander Nurses and Midwives through culturally responsive mentorship. This pilot study evaluates the feasibility and acceptability of the DANMM programme and its impact on cultural safety knowledge and workplace experiences.

N-acetyl cysteine for the treatment of alcohol use disorder: study protocol for a multi-site, double-blind randomised controlled trial (NAC-AUD study).

Introduction: Current treatments for alcohol use disorders (AUD) have limited efficacy. A previous 28-day pilot trial of N-acetyl cysteine (NAC) vs placebo found NAC to be feasible and safe, with evidence of improvement on some measures of alcohol consumption. Thus, the primary aim of the NAC-AUD study is to examine the therapeutic and cost-effectiveness of NAC vs placebo in improving treatment outcomes for AUD.

Performance and Perceptual Responses to Cluster Sets in Pneumatic-Resistance Exercises: Impact of Exercise Selection, Sex, and Strength.

Purpose: This study examined the effects of cluster sets (CS) versus traditional sets (TRAD) on performance and perceptual responses during pneumatic chest press (CP) and leg press (LP). Exercise-specific differences and the influence of sex and strength were also explored.

Methods: Forty-seven recreationally resistance-trained young adults (23 male and 24 female) performed CP and LP at 70% 1-repetition maximum in either CS (4 × [2 × 5], 30-s intraset rest, 150 s between sets) or TRAD (4 × 10, 180-s rest between sets) in randomized order.

A Cross-National Survey of Basketball Strength and Conditioning Coaches' Warm-Up Practices.

Purpose: This study investigated the warm-up practices implemented by strength and conditioning coaches in basketball prior to practices and games. Methods: A total of 88 strength and conditioning coaches from 19 countries, representing leagues such as the NBA, Women's NBA, Euroleague, and International Basketball Federation, completed a semistructured online survey comprising 15 questions. The survey explored various aspects of warm-up routines, including objectives, components, duration, methods, and equipment used.

Identification of α-Azacyclic Acetamide-Based Inhibitors of Na Pump (ATP4) with Fast-Killing Asexual Blood-Stage Antimalarial Activity by Phenotypic Screening.

Malaria treatments are compromised by drug resistance, creating an urgent need to discover new drugs. We used a phenotypic high-throughput screening (HTS) platform to identify new antimalarials, uncovering three related pyrrole-, indole-, and indoline-based series with a shared α-azacyclic acetamide core. These compounds showed fast-killing activity on asexual blood-stage parasites, were not cytotoxic, and disrupted parasite intracellular pH and Na regulation similarly to cipargamin (KAE609), a clinically advanced inhibitor of the Na pump (ATP4).

Novel hypoglossal stimulation markedly improves airflow and airway collapsibility in OSA.

Background: Hypoglossal nerve stimulation (HNS) to treat obstructive sleep apnea (OSA) currently requires placement of a cuff or 'saddle' electrode around or adjacent to the hypoglossal nerve(s). Limitations for this therapy include cost, invasiveness, and variable efficacy.

Research Question: Can HNS applied via percutaneous implantation of a linear, multi-pair electrode array restore airflow to airway narrowing and/or obstruction, and improve airway collapsibility in people with OSA?

Study Design And Methods: Participants with OSA undergoing drug induced sleep endoscopy with propofol were instrumented with an epiglottic pressure catheter, nasal mask and pneumotachograph.

Identifying physical health concerns of people with a mental health condition: an RCT.

Introduction: PhysiCards© have been co-designed to support an interactive, person-led approach to help people with mental health conditions identify and respond to cardiovascular disease (CVD) and other physical health concerns. This study aimed to test the efficacy of the PhysiCards© in assisting people accessing support from a mental health community managed organisation to identify and take action to address CVD and other physical health concerns.

Study Design: Parallel-group randomised controlled trial.

Quality of life in patients with euthymic bipolar disorder: a systematic review and meta-analysis of comparative studies.

Introduction: Bipolar disorder (BD) is a chronic psychiatric condition associated with significant impairments in quality of life (QoL). Although relevant studies have been conducted, findings on QoL among euthymic BD patients have been inconsistent. This systematic review and meta-analysis aimed to quantify QoL impairments across different domains in euthymic BD patients compared to healthy controls and examine potential moderators.

Endocrinologist-led genomic testing for monogenic diabetes in adult diabetes clinics: a feasibility and outcome study.

Aims: Monogenic diabetes (MGD), such as Maturity-Onset Diabetes of the Young (MODY), is under-recognised and under-diagnosed. Accurate diagnosis of MGD requires genetic testing and has important treatment implications. Integrating MGD testing within diabetes clinics can increase testing uptake and MGD diagnosis.

Melatonin's Role in Enhancing Waterlogging Tolerance in Plants: Current Understanding and Future Directions.

Waterlogging, increasingly intensified by climate change, limits oxygen availability in the root zone, disrupting carbon and sugar metabolism, leading to energy deficits and oxidative stress that ultimately impair plant growth and productivity. Melatonin, a versatile signaling molecule, mitigates waterlogging-induced stress by enhancing anaerobic respiration and fermentation under oxygen-deprived conditions, upregulating stress-responsive genes, and restoring energy balance through optimized sugar metabolism. It also reduces oxidative damage by strengthening the antioxidant defense system and further improves stress tolerance by modulating phytohormone signaling and influencing rhizosphere microbiome dynamics.

Adjuvant chemoradiotherapy versus radiotherapy alone in women with high-risk endometrial cancer (PORTEC-3): 10-year clinical outcomes and post-hoc analysis by molecular classification from a randomised phase 3 trial.

Background: The PORTEC-3 trial investigated the benefit of chemoradiotherapy versus pelvic radiotherapy alone for women with high-risk endometrial cancer. We present the preplanned long-term analysis of the randomised PORTEC-3 trial with a post-hoc analysis including molecular classification of the tumours.

Methods: PORTEC-3 was an open-label, multicentre, randomised, international phase 3 trial.

Impurity Profiling of ATS Synthesized From Ring-Substituted APAAN and MAPA Analogs.

Designer precursors for the synthesis of amphetamine-type stimulants pose a significant challenge to law enforcement. The precursors APAAN (α-phenylacetoacetonitrile) and MAPA (methyl α-acetylphenylacetate) became popular in the previous decade and have since been restricted. Recently, a ring-substituted analog of MAPA used for the synthesis of MDMA (3,4-methylenedioxymethamphetamine) was detected, highlighting the potential for criminal misuse of substituted analogs of these designer precursors.

Reimagining Acute Diabetes Care: Insights From the Victorian Virtual Emergency Department.

Objective: New approaches to diabetes care are needed to better identify and manage diabetes emergencies outside of hospitals.

Research Design And Methods: A descriptive analysis of routinely collected data was conducted using data from the Victorian Virtual Emergency Department (VVED) Diabetes, a telehealth service that provides emergency care, including ketone testing by ambulance personnel, for patients across Victoria, Australia, experiencing non-life-threatening diabetes-related emergencies.

Results: Between July and December 2024, VVED Diabetes managed 868 diabetes-related emergencies, with 82.