Sustainable Tea Cultivation with a Rhizobacterial Consortium: A Microbiome-Driven Alternative to Chemical Fertilizers.

The excessive use of chemical fertilizers in tea cultivation threatens soil health, environmental sustainability, and long-term crop productivity. This study explores the application of plant growth-promoting bacteria (PGPB) as an eco-friendly alternative to conventional fertilizers. A bacterial consortium was developed using selected rhizobacterial isolates-, five strains of , and two spp.

Recent Advances in Gluten-Based Active and Intelligent Food Packaging: A Review.

Packaging is considered essential for protecting food from spoilage and enhancing food safety. Synthetic, petrochemical-derived plastics are commonly utilized, but improper use and inadequate recycling have resulted in severe environmental impacts and have imposed serious health risks. To address these concerns, biopolymer-based plastics with active and intelligent functions have been increasingly emphasized in the field of food science, with the goal of improving food safety and reducing packaging waste.

Responses in green alga Trentepohlia to ultraviolet-B (UV-B) radiation: Physiological and metabolic implications for stress adaptation.

In the present study, we evaluated the physiological and metabolic adaptations of UV-B stress in the green alga Trentepohlia sp. This green alga reflected remarkable resilience to UV-B stress by reflecting a strong adaptation, mediated by physiological and metabolic alterations. The pigment content, such as chlorophyll a, chlorophyll b, total chlorophyll, and carotenoid contents, was unchanged compared to the control, reflecting efficient photosynthetic activities under UV-B stress.

Pectin in gut health and beyond: A review.

The biodegradation of pectin in the distal colon induced by pectinases has emerged as a primary focus of growing research in the last two decades. Along with inulin and resistant starches, pectin belongs to dietary fibres known as microbiota-accessible carbohydrates. Although humans lack the enzymes necessary to break these polysaccharides down, the colonic microbiota metabolized them into products, including short-chain fatty acids (SCFAs), which are recognized to be highly bioactive.

Curcumin and quercetin can ameliorate arsenic and smokeless tobacco induced reproductive toxicity in female mice.

Arsenic contamination of ground water is a global problem. Consumption of smokeless tobacco called '' is a common lifestyle practice in Assam, India. As a result, the population is more vulnerable to health outcomes with regard to female reproductive anomalies.

Incidence of carbapenem non-susceptible Chromobacterium violaceum harboring bla from clinical-environmental interface.

Purpose: Chromobacterium violaceum is an opportunistic environmental pathogen, which act as a potential source of antimicrobial resistance genes. Acquisition of such genes by non-susceptible organisms, aided by mobile genetic elements possess a serious clinical threat. With the rise and expansion of carbapenem resistance worldwide, the present study investigates two carbapenem non-susceptible Chromobacterium violaceum isolates through whole genome sequencing.

Cancer Chemopreventive Potential of Grown in Southern Thailand: A Bioassay-Guided Isolation of Vicenin 1 as the Active Compound and Studies on Related -Glycosyl Flavones.

(Euphorbiaceae) is an indigenous vegetable that has been used in southern Thai traditional medicine and cuisine. A bioassay-guided approach was adopted to investigate the phytochemicals and chemopreventive potential of leaves and stems. Phytochemical investigation of the active MeOH fractions afforded six known compounds, including caffeic acid (), isovitexin (), and vicenins 1-3 () from leaves and hexadecanoic acid methyl ester () from stems.

Impact of anthropogenic disturbance and climate on bamboo distribution in shifting cultivation landscapes of Northeast India.

Bamboo, a multipurpose plant species found in tropical and subtropical regions, covers about 1% of the earth's landmass and provides numerous ecosystem services. This study focuses on mapping the distribution of bamboo in the Dima Hasao district of Assam, India, and examines the influence of anthropogenic disturbance and climate on bamboo occurrence in shifting cultivation landscapes. Bamboo distribution was mapped using spectral and textural variables from Sentinel-2 imagery (March and November 2022) and topographic data from the Shuttle Radar Topography Mission digital elevation model.

Silencing of ubiquitin specific protease-15 activates components of innate immune response and inhibits dengue virus infection.

Innate immune responses induced by interferons are one of the key defense mechanisms against virus infections. It is activated by specific sensors in host cells that detect particular features of viruses. Secretion of interferons stimulate interferon-stimulated genes (ISGs) that act as antiviral effectors and inhibit virus infections.

Assessing the role of cattle manure-derived biochar in stress mitigation of mung bean seedlings growing in arsenate-enriched soil.

Arsenic (As) contamination of agroecosystems is one of the most emerging threats affecting crop quality and human health. Thus, there is an insistent need to develop sustainable strategies for mitigating As-contamination and its impact on plants. Biochar, a porous carbonaceous material mainly derived from waste biomass, is known to sequester toxic elements from various substrates, including contaminated soil, and is considered a viable and sustainable option for remediation as well as stress mitigation.

The therapeutic potential of cyanidin-3-O-glucoside relating to female reproductive health.

Cyanidin-3-O-glucoside (C3G), a dietary flavonoid found in berries, exhibits strong antioxidant, anti-inflammatory, and anticancer properties. It plays a role in female reproductive health by protecting ovarian cells from oxidative stress while inhibiting tumour growth and inducing apoptosis in ovarian and cervical cancer cells. C3G can modulate estrogen receptors, growth factors, and apoptosis- and angiogenesis-related pathways.

Genistein - A Broad-spectrum Bioactive Compound with Diverse Pharmacological Potential: A Systematic Review.

Introduction: Genistein is an isoflavone primarily extracted from soybeans and the Dyer's broom (Genista tinctora L.). It has been extensively studied using various extraction methods and characterized via NMR for structural elucidation.

Echocardiographic Evidence of Left Ventricular Dysfunction in COPD: Relationship with Disease Severity.

: Chronic obstructive pulmonary disease (COPD) significantly impacts morbidity and mortality, often due to cardiovascular comorbidities that are frequently overlooked. This study examines the prevalence of left ventricular dysfunction in COPD patients and its association with disease severity, hypoxemia, and exacerbation frequency. : COPD patients ( = 114) were evaluated using spirometry and transthoracic echocardiography.

Determination of precipitating factors for breakthrough seizures among patients with epilepsy in a tribal area of Jharkhand: A retrospective study.

Background: Breakthrough seizures are an essential aspect to consider while treating epilepsy. No study has been done on the precipitating factors for breakthrough seizures in the tribal area of Jharkhand. Hence, awareness regarding the possible precipitating factors of breakthrough seizures is vital to prevent their occurrence.

Unveiling potent anti-leishmanial agents: a QSAR exploration of diverse chemical scaffolds targeting amastigotes.

Leishmaniasis, caused by spp. remains a major global health concern due to drug resistance, toxicity, non-specificity, and prolonged treatments. Addressing the need for new therapeutics, we investigated a range of bioactive compounds, including chalcones, pyrimidines, quinolines, azoles, sulphonamides, flavonoids, and quinazoline derivatives, targeting amastigotes.

Protocol for the economic evaluation alongside the PARTICIPATE (PArticipatory Research model for medicaTIon adherenCe In People with diAbetes and hyperTEnsion) multicenter cluster randomized trial.

Introduction: Using the community-based participatory research (CBPR) methodology, sustained peer group treatment has effectively improved medication adherence. Although many studies investigate the effectiveness of peer group therapy, there is a lack of evidence addressing the cost-effectiveness of CBPR models in low- and middle-income countries. This protocol outlines the methods for the economic evaluation of the PArticipatory Research model for medicaTIon adherenCe In People with diAbetes and hyperTEnsion (PARTICIPATE) trial to determine whether the CBPR approach to enhance medication adherence among patients with diabetes and/or hypertension is cost-effective in India.

Alginate-based coating in post-harvest fruits preservation: A comprehensive review.

Alginate-based films and coatings are known to improve food quality and extend the shelf life. Fruits are inherently perishable, and the application of coatings, particularly those based on alginate, is gaining traction as an effective method to extend their shelf life and improve preservation. The chemistry of alginate, its role in food packaging, and its challenges are also briefly discussed.

Designing a cellular MicroRNA-based approach to silence bat-borne Nipah virus genes.

The bat-borne Nipah virus, known for causing high mortality rates in humans, has been reported in India (Megaderma spasma), Bangladesh (Pteropus medius), and Malaysia (Pteropus vampyrus) with different bat species serving as reservoirs. The virus also infects various animals, which often act as intermediate hosts in the transmission to humans. Due to the high fatality rates associated with Nipah virus outbreaks, the World Health Organization has flagged it as a significant public health concern, prompting extensive research into the development of antiviral therapeutics and vaccines.

Review on various activator-assisted polymer grafting techniques for smart drug delivery applications.

Activator-assisted polymer grafting has emerged as a crucial approach in the development of advanced drug delivery systems, enabling precise regulation of drug release, targeting, and biocompatibility. In contrast to traditional formulation techniques, activator-mediated grafting methods, including redox initiation, photo-induced reactions, plasma treatment, and enzymatic catalysis, provide improved functionalization of polymers, achieving high grafting efficiency and adjustable properties. This review presents a thorough assessment of polymer grafting methodologies, encompassing grafting-to, grafting-from, and grafting-through techniques, with a detailed examination of the function of activators in facilitating these processes.

Assessment of potential probiotic lactic acid bacteria in rice-based fermented products of Southern Assam, Northeast India.

Introduction: Indigenous ethnic fermented products have gained recognition as valuable sources of probiotic bacteria, which play a crucial role in maintaining the natural balance of the gut microbiota.

Methods: Twenty-five samples of rice-based fermented products were analyzed, recovering 16 LAB isolates, preliminarily identified by morphological and biochemical tests, and further confirmed using 16S rRNA gene sequencing. Subsequent assessments, safety evaluations and technological properties were performed on all isolated strains.

pH-responsive nanocapsules loaded with 5-fluorouracil-coated green-synthesized CuO-ZnO NPs for enhanced anticancer activity against HeLa cells.

Cancer represents a form of unregulated cellular proliferation, persisting as a significant challenge to global health. Despite the progress made in therapeutic interventions, challenges such as inadequate drug selectivity, systemic toxicity, and the development of drug resistance continue to pose considerable obstacles. In response to these barriers, we prepared pH (Stimuli)-responsive gelatin (GA) nanocapsules (NCs) that encapsulate 5-fluorouracil (5-FU)-coated CuO-ZnO nanoparticles (NPs) to achieve a combined effect in anticancer activity.

The Global State of Contemporary Andrology Practice: A Comprehensive Analysis of Clinical Practice, Training Pathways, and Emerging Challenges.

Purpose: This study evaluates the current state of andrology practice worldwide, identifies challenges faced by clinicians, and explores training, certification, and research opportunities. It also seeks to redefine the qualifications necessary to be recognized as an andrologist and to propose areas for standardization and improvement.

Materials And Methods: A global, cross-sectional survey was conducted using a 48-question online questionnaire designed by international experts.

Influence of AHL and Imipenem on bla Conjugation and sRNA Rydb Expression in Escherichia coli.

The rise of carbapenem resistance in Escherichia coli is mainly due to the rapid spread of carbapenemase-encoding genes through horizontal gene transfer, particularly via bacterial conjugation. Recent research has highlighted the role of a small RNA molecule known as RydB in bacterial conjugation, specifically through its interaction with the protein SdiA. This study investigated the effects of sub-inhibitory concentrations of imipenem and N-acyl homoserine lactones (AHLs) on the expression of rydB in E.

Can pristine/modified graphene repair N7-methylated guanine lesions? A DFT study.

Context: Graphene is considered to be a wonder material with widespread applications. However, its potential for recovering methylated DNA bases has not yet been explored. DNA methylation is implicated in the development of several health issues such as mutation, ageing, cancer and neurodegenerative diseases.