Selective inhibition of rabies virus gene expression by human miRNAs: a therapeutic approach using the 7mer-m8 model.

MicroRNAs, abbreviated as miRNAs, have a substantial impact on viral infections through their ability to control gene expression and influence the interactions between the host and the virus. This work investigates the capacity of miRNAs to selectively inhibit the expression of rabies virus genes, specifically Nucleoprotein N, Phosphoprotein M1 and M2, Transmembrane Glycoprotein G, and L protein. The 7mer-m8 model was utilized to identify human miRNAs that target these viral genes.

Mesogenic L-histidine Based Schiff Base and its Zn(II) Complex: Synthesis, Photophysical Properties, AIE and TD-DFT Study.

A new photoluminescent Schiff base ligand derived from L-histidine and its zinc(II) complex have been synthesized and characterized by various analytical techniques. The mesomorphic properties of the compounds were examined, revealing that only the ligand exhibits liquid crystalline property of the nematic phase. The photophysical properties of both the ligand and its zinc(II) complex were studied in solvents of varying polarity using UV-Vis and emission spectroscopic techniques.

An efficient method for the removal of para-methoxybenzyl group of carbohydrates using sulfonated graphene as a sustainable acid catalyst.

A simple, efficient, and chemoselective deprotection of p-methoxybenzyl ethers in the presence of sulfonated graphene as a solid acid catalyst is presented. The developed method demonstrated broad functional group compatibility, effectively tolerating various protecting groups such as benzyl, benzoyl, TBDPS, naphthylmethyl, isopropylidene, and benzylidene. It achieved good to excellent yields within short reaction times, showcasing its efficiency and versatility.

Retraction notice to "An assessment of the impact of traditional rice cooking practice and eating habits on arsenic and iron transfer into the food chain of smallholders of Indo-Gangetic plain of South-Asia: Using AMMI and Monte-Carlo simulation model" [Heliyon 10 (2024) e28296].

[This retracts the article DOI: 10.1016/j.heliyon.

Transcriptional response study of auto inducer-2 regulatory system in Escherichia coli harboring bla.

Background: The emergence of carbapenem resistance in gram-negative bacteria such as Escherichia coli is one of the world's most urgent public health problems. E. coli, which encounter a diverse range of niches in host can rapidly adapt to the changes in surrounding environment by coordinating their behavior via production, release and detection of signal molecules called autoinducers through a cell density dependent communication system known as quorum sensing.

Microbial enhanced oil recovery: process perspectives, challenges, and advanced technologies for its efficient applications and feasibility.

The depletion of crude oil resources, coupled with increasing energy demands, underscores the urgency for innovative recovery strategies. Despite traditional oil recovery operations, a substantial portion of residual oil (~70%) persists within the intricate capillary networks of oil reservoirs' pore spaces. Microbial Enhanced Oil Recovery (MEOR) is an ecofriendly and cost-effective tertiary oil recovery method that offers a sustainable approach by utilizing microorganisms and their metabolites to extract this residual oil from mature or depleted reservoirs.

Analysis of Age Appropriate Measles Immunisation among the Eligible Children in India: A Cross-Sectional Analysis of National Family Health Survey-5.

Background: Measles continues to pose a significant health threat to children in India, contributing significantly to the global burden of measles-related fatalities. Moreover, a considerable number of children did not even receive their first dose of the measles vaccine, and those who did generally did not receive it at the recommended age. Additionally, there is limited information available in India about age-appropriate measles immunization coverage.

Exploring the potential of 2D beryllonitrene as a lithium-ion battery anode: a theoretical study.

The development of new and high-capacity anode materials for Li-ion batteries (LIBs) can lead to significant improvements in energy storage technology, promoting sustainable practices, and enabling a wider adoption of clean energy solutions. Herein, the recently synthesized 2D beryllonitrene has been studied computationally to evaluate its Li capacity and feasibility as an anode material in LIBs. 2D BeN can load a single layer of Li above and below the plane giving a theoretical capacity of 824 mA h g.

Improving the hydrophobic nature of biopolymer based edible packaging film: A review.

Biopolymer-based polymer compounds mainly protein and polysaccharide are commonly used in biodegradable packaging. Gelatin, cellulose, starch, chitosan, pectin, and alginate are widely used for producing biodegradable packaging films because of their nontoxicity and safety. However, some drawbacks need to be solved before employing them in food packaging, such as inappropriate wettability, low barrier properties, low mechanical properties and high moisture sensitivity.

Potentials of urban waste derived biochar in minimizing heavy metal bioavailability: A techno-economic review.

Contamination of heavy metals (HMs) in agroecosystem presented an additional dimension of complexity along with the adverse consequences of climate change for the scientific fraternity. The increasing population and urbanization on the other hand are regarded as the main sources of urban waste (UW). Holistic utilization of UW-derived biochar (BC) has shown potential to be utilized as a source of soil supplement in the agriculture sector, fulfilling several sustainable development goals (SDGs).

Multi-targeted benzylpiperidine-isatin hybrids: Design, synthesis, biological and in silico evaluation as monoamine oxidases and acetylcholinesterase inhibitors for neurodegenerative disease therapies.

Neurodegenerative diseases (NDDs) like Alzheimer's and Parkinson's, characterized by gradual loss of neuronal structure and function, results in cognitive and motor impairments. These complex disorders involve multiple pathogenic mechanisms, including neurotransmitter imbalances, oxidative stress, and protein misfolding, necessitating multifunctional therapeutic approaches. Piperidine and isatin are valuable scaffolds in drug design due to their favorable pharmacokinetic profiles, ability to cross blood-brain barrier, and ease of modification.

Impact of Tray and Freeze Drying on Physico-Chemical and Functional Properties of Underutilized ().

Roxb. (), an underutilized minor fruit from Assam, holds significant potential as it exhibits substantial traditional medicinal properties. However, its preservation and utilization remain limited, necessitating effective processing techniques.

Bryophyllum pinnatum Induces p53-Dependent Apoptosis of Colorectal Cancer Cells via Increased Intracellular ROS and G2/M Cell-Cycle Arrest In Vitro and Validated in Silico by Molecular Docking.

Chemotherapy, radiotherapy and surgical treatments of cancer having several limitations and toxic side-effects, have led researchers to focus towards development of alternative natural plant-based therapeutics that can reduce disease severity. The present research work is mainly focussed towards identifying molecular mechanisms of apoptosis of colorectal cancer cells (HCT116) by perennial herb Bryophyllum pinnatum leaf-extract via both in vitro experimentations and in silico analysis. B.

Cell-cell junctional proteins in cancer.

A hallmark change during carcinogenesis is disruption or dysregulation of cell-cell junctions. It enables a transformed cell to adopt mesenchymal phenotype and acquire higher potential to migrate and invade. This ultimately leads to cancer metastasis.

Landscape-level human disturbance results in loss and contraction of mammalian populations in tropical forests.

Tropical forests hold most of Earth's biodiversity and a higher concentration of threatened mammals than other biomes. As a result, some mammal species persist almost exclusively in protected areas, often within extensively transformed and heavily populated landscapes. Other species depend on remaining remote forested areas with sparse human populations.

Carbon Nanodots-Based Polymer Nanocomposite: A Potential Drug Delivery Armament of Phytopharmaceuticals.

Carbon nanodots (CNDs) have garnered significant attention as viable drug delivery vehicles in recent years, especially in the field of phytomedicine. Although there is much promise for therapeutic applications with phytomedicine, its effectiveness is frequently restricted by its low solubility, stability, and bioavailability. This paper offers a thorough synopsis of the developing field of phytomedicine drug delivery based on CND.

Static and Dynamic Studies of Excitation in a Fullerene-Anthracene Complex.

We investigate the static and dynamic aspects of an anthracene-fullerene complex. Our detailed investigation includes (a) systematic scrutiny of the complex in its stable state through the examination of its chemical reactivity parameters and absorption spectra and (b) exploration of its dynamic behavior in excited states at a femtosecond time scale. To achieve this, we employ a combination of molecular dynamics (AIMD) and time-dependent density functional theory (TDDFT) to study not only the system's behavior in the excited state but also the temporal evolution of chemical reactivity parameters when it moves in a particular excited state.

Targeting Neurodegeneration: The Emerging Role of Hybrid Drugs.

Neuron loss is the main feature of neurodegenerative diseases. The two most prevalent neurodegenerative illnesses are Parkinson's and Alzheimer's diseases. While several medications are currently approved to treat neurodegenerative disorders, most of them only address the symptoms that are related to the disorders.

Arsenic-induced mice model of Parkinson's disease: Revealing the neurotoxicity of arsenic through mitochondrial complexes inhibition and dopaminergic neurodegeneration in the substantia nigra region of brain.

The role of environmental contaminants in causing Parkinson's disease (PD) is well known, with rotenone and paraquat being the notable neurotoxins. Traces of the metalloid arsenic are frequently found in drinking water which is considered a threat to the brain's health. Pre-clinical and epidemiological studies have associated arsenic with PD whereby behavioral and neurochemical alterations were observed.

MicroRNA-regulated suppression of some overexpressed genes in schizophrenia and their evolutionary significance.

Impaired formation of the brain or nervous system is the root cause of neurodevelopmental disorders which appear in pregnancy or soon after birth. One such neurodevelopmental disorder is Schizophrenia. Among the most serious forms of psychosis, Schizophrenia (SCZ) affects 1 % of the general population.

Stem Cell Therapy Modulates Molecular Cues of Vasogenic Edema Following Ischemic Stroke: Role of Sirtuin-1 in Regulating Aquaporin-4 Expression.

Background: Conventional post-stroke edema management strategies are limitedly successful as in multiple cases of hemorrhagic transformation is being reported. Clinically, acute-ischemic-stroke (AIS) intervention by endovascular mesenchymal stem cells (MSCs) have shown benefits by altering various signaling pathways. Our previous studies have reported that intra-arterial administration of 1*10 MSCs (IA-MSCs) were beneficial in alleviating post-stroke edema by modulating PKCδ/MMP9/AQP4 axis and helpful in preserving the integrity of blood-brain-barrier (BBB).

Fullerene (C & C)-Meso-Tris-4-Carboxyphenyl Porphyrin Dyads Inhibit Entry of Wild-Type and Drug-Resistant HIV-1 Clades B and C.

The biological applications of noncationic porphyrin-fullerene (P-F) dyads as anti-HIV agents have been limited despite the established use of several cationic P-F dyads as anti-cancer photodynamic therapy (PDT) agents. This article explores the potential of amphiphilic non-cationic porphyrin-fullerene dyads as HIV-1 inhibitors under both PDT (light-treated) and non-PDT (dark) conditions. The amphiphilic P-F dyads, PBC and PBC, demonstrated enhanced efficacy in inhibiting the entry and production of HIV-1 (subtypes B and C).

Integrated biorefinery approach for sustainable production of biodiesel, bioplastics and high value bioproducts from a bloom forming alga, Botryococcus braunii.

The global shift towards sustainable energy and bioproducts has intensified research on algae. Renewable green biofuel can address and provide solutions to both energy crisis and climate change challenges. Botryococcus braunii, a bloom forming green microalga, known for its high lipid content and potential for biofuel production has been explored in the present study.

Microbial exopolysaccharides: Classification, biosynthetic pathway, industrial extraction and commercial production to unveil its bioprospection: A comprehensive review.

Polysaccharides, found universally in all living-species, exhibit diverse biochemical structures and play crucial roles in microorganisms, animals, and plants to defend against pathogens, environmental stress and climate-changing. Microbial exopolysaccharides are essential for cell adhesion and stress resilience and using them has notable advantages over synthetic polysaccharides. Exopolysaccharides have versatile structures and physicochemical properties, used in food systems, therapeutics, cosmetics, agriculture, and polymer industries.

A study on indolo[3,2,1-]carbazole donor-based dye-sensitized solar cells and effects from addition of auxiliary donors.

Density functional theory has been employed to study indolo[3,2,1-]carbazole donor-based dyes, incorporating one and two units of 2,4-dimethoxybenzene auxiliary donors. Electrostatic potential analysis highlights the dye with one auxiliary donor (D2) as having the highest charge-donating capability. Structural analysis shows that auxiliary donors enhance planarity, reduce steric hindrance, and improve π-conjugation.