Efficacy and safety of ensifentrine in treatment of COPD: a systematic review and meta-analysis of clinical trials.

Background: Chronic obstructive pulmonary disease (COPD) is a progressive lung disease marked by airway inflammation and obstruction. Ensifentrine is a novel inhaled PDE3 and PDE4 inhibitor with both bronchodilator and anti-inflammatory effects.

Objectives: Comprehensively review the available evidence on ensifentrine and its potential role in COPD management.

Converting waste into opportunity: silica nanoparticles for mitigating salinity stress in wheat "".

Silica nanoparticles (SiNPs) have been promising to be a soil additive to improve plant abiotic stress tolerance, including salinity, which has been proven to strongly restrain wheat growth and yield. The present study assessed the effect of SiNPs on wheat growth and physiological performance under salt stress in a replicated pot experiment. Three concentration levels of SiNP (0%, 5%, and 10%) and three salinity levels of irrigation (0, 25, and 50 mM NaCl) were utilized.

Efficacy of transcranial direct current stimulation on seizure control in patients with refractory epilepsy: a systematic review and meta-analysis of randomized controlled trials.

Drug-resistant epilepsy is a challenging condition that affects around 30% of all patients with epilepsy. Evidence regarding treatment options is limited, especially for surgery and invasive techniques. However, non-invasive techniques constitute a promising alternative for these patients.

Understanding Communication Gaps in MSK Counselling: Bridging Patient and Doctor Perspectives.

Introduction: Communication gaps between patients and physicians in musculoskeletal (MSK) care can affect satisfaction and outcomes. While many studies focus on patient dissatisfaction, few compare it directly with physician perceptions. This study aimed to identify perceptual gaps during MSK consultations by analysing both perspectives across key communication domains.

Efficacy of Janus Kinase Inhibitors in Alopecia in Jordanian Patients: A Retrospective Cohort Study.

Introduction  Alopecia areata (AA) is an autoimmune disorder causing non-scarring hair loss on the scalp, eyebrows, eyelashes, and other areas. Janus kinase (JAK) inhibitors have emerged as promising treatments, but data on their efficacy in Middle Eastern populations, including Jordanians, are limited. The Severity of Alopecia Tool (SALT) score is commonly used to assess disease severity, while Clinician-Reported Outcome (ClinRO) measures provide additional insights.

Nephroprotective Effects of Fraxinus Hookeri Wenz. Against Renal Toxicity and DNA Oxidative Damages Induced by CCl in Rats.

Recognizing the therapeutic value of the Genus Fraxinus worldwide, this study evaluates the antioxidant potential of Fraxinus hookeri Wenz. (F. hookeri) against CCl-induced nephrotoxicity in rats.

Parental Stress and Coping in Autism Spectrum Disorder: A Network Analysis of Internalizing and Externalizing Symptoms in Children With Autism Spectrum Disorder.

Introduction: Parental stress and coping strategies play a pivotal role in shaping mental health outcomes for children with Autism Spectrum Disorder (ASD). While traditional research has examined linear relationships, network analysis offers a novel lens to uncover dynamic interactions between parental factors and child psychopathology. This study employs advanced network modeling to map how specific stress dimensions and coping mechanisms differentially associate with internalizing (e.

Modulation of interleukins 38 and 1 Beta gene expression by N-(4-benzoylphenyl)-5-nitrofuran-2-carboxamide in Triton WR-1339 induced hyperlipidemic rats.

Background: Atherosclerosis (AS) is characterized by a gradual plaque buildup within the arteries, resulting in hardened and narrowed arteries. Thus, it leads to blood flow limitation and increased risk of critical diseases. Hyperlipidemia is correlated with inflammation, as seen with increased expression of different inflammatory markers including tumor-necrosis factor-alpha (TNF-α), C-reactive protein (CRP), chemokines and interleukins.

Hormonal, antioxidant, and body composition differences in national level male athletes: a comparative study of aerobic and anaerobic training.

Background: Competitive athletes exhibit distinct physiological adaptations depending on their sport type and training techniques. These variations influence body composition, hunger-regulating hormones, and antioxidant defense mechanisms, which collectively impact performance, recovery, and progression. This study aimed to compare body composition, serum levels of ghrelin, leptin, and glutathione (GSH), and their interrelationships in national level male athletes engaged in aerobic and anaerobic sports.

Psychometric Properties of the Barriers to and Facilitators of Implementing the Sepsis Six Care Bundle (BLISS-1) Questionnaire.

Background: Sepsis, a severe medical condition caused by a dysregulated host response to infection, accounts for 20% of global fatalities. While simplifying early sepsis treatment with the Sepsis Six care bundle has been shown to reduce mortality by 46.6%, multiple barriers often prevent clinical nurses from adhering to sepsis care recommendations.

Comparative effectiveness of natalizumab and anti-CD20 monoclonal antibodies in relapsing-remitting multiple sclerosis: a real-world propensity-score matched study.

Background: Head-to-head randomised trials or real-world studies comparing the safety and efficacy of natalizumab and anti-CD20 monoclonal antibodies are limited. This study aimed to compare the effectiveness and safety of natalizumab versus ocrelizumab/rituximab in a real-world cohort of relapsing-remitting multiple sclerosis (RRMS) patients using data from the Middle East and North Africa Committee for the Treatment and Research in Multiple Sclerosis (MENACTRIMS) registry.

Methods: This registry-based, retrospective, multicentre study was carried out in seven Middle Eastern countries by analysing data from the MENACTRIMS registry.

Predictors of sperm retrieval success in first-time and repeated Micro-TESE for nonobstructive azoospermia.

Introduction: Microdissection testicular sperm extraction (micro-TESE) is the preferred sperm retrieval method, although success rates vary based on factors such as age and hormone levels. We evaluate sperm retrieval outcomes in first-time and repeated micro-TESE, identifying predictors of success to guide clinical management.

Material And Methods: Retrospective study analyzed 152 men with nonobstructive azoospermia (NOA) who underwent micro-TESE between 2020 and 2022.

A qualitative study of contributing factors to burnout among Jordanian midwives.

Background: The healthcare system, particularly the midwifery profession in Jordan, faces significant challenges that negatively impact midwives and the quality of maternal care, primarily due to resource limitations and increasing service demands. While quantitative research has examined burnout levels among Jordanian midwives, there is limited qualitative insight into their lived experiences, particularly in the southern region of Jordan.

Objective: This study aimed to explore the factors contributing to burnout among midwives in southern Jordan and to gain a deeper understanding of their professional experiences within the current healthcare context.

The relationship between nursing informatics competencies and clinical decision-making among registered nurses working at tertiary hospitals.

Aim: This study aims to explore the relationship between nursing informatics competencies and clinical decision-making among nurses in Jordan.

Design: A cross-sectional, descriptive-correlational design was used with a sample of 249 registered nurses from three tertiary governmental hospitals in Jordan, utilizing the Self-Assessment of Nursing Informatics Competencies Scale and the Clinical Decision-Making in Nursing Scale.

Results: Nurses reported moderate-to-high informatics competencies ( = 3.

Improving HbA1c Levels by Methylcobalamin Vitamin in Diabetic Volunteers, Combined with Dapagliflozin as Type 2 Diabetes Mellitus Routine Treatment: A Controlled Randomized, Double-blind Trial.

Background: Diabetes mellitus is predominantly a growing global problem interconnected proportionally with obesity escalation. The current study evaluated the prognostic implications of vitamin B12 administration on Body Mass Index (BMI) and glycosylated hemoglobin (HbA1c) levels in type 2 diabetic patients treated with dapagliflozin.

Methods: In this controlled randomized, double-blind trial, 160 patients for each arm were enrolled from July 2022 to June 2023 in Amman, Jordan.

Lauric acid modulates cytochrome 4V2 expression in the human THP1 macrophages.

Objectives: Macrophages play a major role in the inflammation. Recently, the expression of some cytochrome P450 (CYP450) 4 family enzymes was identified in the macrophages including CYP4V2, which metabolizes saturated fatty acids. Lauric acid is unsaturated fatty acid, which can induce inflammation.

Bayesian Model Prediction for Breast Cancer Survival: A Retrospective Analysis.

Objective: Over the recent years, machine learning (ML) models have been increasingly used in predicting breast cancer survival because of improvements in ML algorithms. However, cancer researchers still face a significant challenge in accurately predicting breast cancer patients' survival rates. The purpose was to predict breast cancer survival using a Bayesian network.

Readiness, knowledge, and attitudes of healthcare professionals in Jordan toward Monkeypox: a cross-sectional survey.

Healthcare professionals play a vital role in managing and containing disease outbreaks. This study evaluated the level of readiness, knowledge, and attitudes of healthcare professionals in Jordan towards Monkeypox (Mpox) disease and explored factors associated with poor level of readiness, poor level of knowledge, and negative attitude toward Mpox. A pre-validated cross-sectional survey was carried out on healthcare professionals (physicians, pharmacists and nurses) actively involved in patient care in Jordan from 15 July to 30 September 2024.

Role of Malnutrition in Shaping Academic Achievement Among Primary School Children: A Nutritional Health Study.

Objective: Limited research focuses on the relationship between malnutrition and academic achievement in primary school students in Jordan. This study aimed to investigate the relationship between malnutrition indicators, including wasting, stunting, thinness, obesity, overweight, and body mass index (BMI), and academic achievement among primary school children in Jordan.

Methods: A correlational study design was used.

A generative adversarial network-based accurate masked face recognition model using dual scale adaptive efficient attention network.

Masked identification of faces is necessary for authentication purposes. Face masks are frequently utilized in a wide range of professions and sectors including public safety, health care, schooling, catering services, production, sales, and shipping. In order to solve this issue and provide precise identification and verification in masked events, masked facial recognition equipment has emerged as a key innovation.

The Association Between Nutritional Status, Diet Quality, and Sleep Quality Among the Elderly in Jordan: A Cross-Sectional Study.

The percentage of the elderly population has increased worldwide. It has been estimated that environmental factors such as eating habits, sleep quality, and physical activity could be responsible for up to 75% of the aging process. To assess the nutritional status, diet quality, and sleep quality among the elderly in Jordanian.

A dual-modal approach to lung cancer treatment: in vitro and in silico. Evaluation of a hybrid nanocomposite for synergistic chemotherapy.

This study investigates the therapeutic potential of a nanosilica-cysteine composite loaded with arsenic trioxide (SC-As) in combination with cisplatin (CIS), paclitaxel (PTX), and doxorubicin (DOX) for lung/breast cancer treatment. Through comprehensive synthesis, characterization (ATR-FTIR, XRD, SEM, TEM, DLS), and cytotoxicity assessments, SC-As demonstrated superior potency with IC₅₀ values as low as 7.29 ± 1.

Antibiotic resistance profile of Escherichia coli among urological adult patients in public hospital of Thaiban at Madaba Governorate/Jordan.

Escherichia coli is the most prevalent bacterium causing Urinary Tract Infections (UTI). The objective of this study was to identify the prevalence of E. coli organisms causing UTIs in Thaiban region at Madaba city and to assess their pattern of antibiotic resistance.

Dual antiplatelet therapy versus aspirin alone in acute ischemic stroke or transient ischemic attack: A meta-analysis and trial sequential analysis of randomized controlled trials.

IntroductionData regarding the role of dual antiplatelet therapy in patients with ischemic stroke or transient ischemic attack are limited. This study aimed to systematically review and analyze the efficacy and safety of dual antiplatelet therapy compared with aspirin alone in patients with acute ischemic stroke or transient ischemic attack.MethodsWe searched PubMed, Embase, Scopus, Cochrane, and Web of Science databases from inception to August 2024 and identified randomized controlled trials comparing dual antiplatelet therapy with aspirin alone in patients with stroke.