Publications by authors named "Surendra Kumar Shukla"

Masked identification of faces is necessary for authentication purposes. Face masks are frequently utilized in a wide range of professions and sectors including public safety, health care, schooling, catering services, production, sales, and shipping. In order to solve this issue and provide precise identification and verification in masked events, masked facial recognition equipment has emerged as a key innovation.

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Article Synopsis
  • Therapeutic vaccines are emerging as a viable option for active immunotherapy in treating various cancers, focusing on enhancing the immune system's ability to target tumors specifically.
  • Clinical trials have advanced the development of these vaccines, leading to FDA approval for the first therapeutic cancer vaccine.
  • The review covers different types of cancer vaccines, their development strategies, challenges posed by tumor-induced immune suppression, and potential ways to create effective and lasting anti-tumor immune responses.
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Chemotherapy is a life-sustaining therapeutic option for cancer patients. Despite the advancement of several modern therapies, such as immunotherapy, gene therapy, etc., chemotherapy remains the first-line therapy for most cancer patients.

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Purpose Of Review: An imbalance in reactive oxygen species (ROS) homeostasis can wreak damage to metabolic and physiological processes which can eventually lead to an advancement in cardiovascular diseases (CVD). Mitochondrial dysfunction is considered as a key source of ROS. The purpose of the current review is to concisely discuss the role of bioactive compounds in the modulation of cardiovascular metabolism and their potential application in the management of cardiovascular diseases.

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Alzheimer's disease is characterized by the presence of abnormal protein bundles in the brain tissue, but experts are not yet sure what is causing the condition. To find a cure or aversion, researchers need to know more than just that there are protein differences from the usual; they also need to know how these brain nerves form so that a remedy may be discovered. Machine learning is the study of computational approaches for enhancing performance on a specific task through the process of learning.

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Background: The HBx oncoprotein of hepatitis B virus has been implicated in the development and progression of hepatocellular carcinoma (HCC). HBx engages multiple signalling and growth-promoting pathways to induce cell proliferation and enhance ribosome biogenesis. Interestingly, the levels of Upstream Binding Factor (UBF) required for rDNA transcription and ribosome biogenesis are found elevated in the HCC patients.

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Viral and cellular oncogenes are well known to enhance rRNA synthesis, leading to increased ribosome biogenesis and cell proliferation. Our study on the molecular underpinnings of the interaction between viral HBx and c-Myc, which is implicated in the development of hepatocellular carcinoma, showed a marked increase in the biosynthesis of rRNA, ribosomes and protein in hepatoma cells. A profound alteration in the nucleolar morphology and biochemical content of these cells was also observed.

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At present almost all the pectinolytic enzymes used for industrial applications are produced by fungi. There are a few reports of pectinase production by bacterial strains. Therefore, in the present study, seventy-four bacterial strains, isolated from soil and rotten vegetable samples, were screened for polygalacturonase production.

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Ethnopharmacological Relevance: Butea monosperma (Lam.) (Fabaceae) popularly known as 'flame of the forest' has been widely used in the traditional Indian medical system of 'Ayurveda' for the treatment of a variety of ailments including liver disorders.

Aim Of The Study: To evaluate the antioxidative, anti-inflammatory, hepatoprotective and anti-cancer activities of the aqueous extract of Butea monosperma flowers.

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