Investigating the Role of Gene Polymorphisms in Hypertension: Evidence from the Jordanian Population.

Purpose: Hypertension (HTN) is a complex disorder regulated by multiple physiological systems. Each individual's underlying genetic architecture strongly influences inter-individual variability in therapeutic responses to HTN. Consequently, identifying candidate genes that contribute to the genetic basis of HTN remains a significant challenge.

Community pharmacists' knowledge, practices and barriers in diabetes mellitus management during Ramadan in Jordan: a cross-sectional study.

Objective: To assess the knowledge and practices of community pharmacists regarding managing diabetes in fasting patients during Ramadan and the barriers the community pharmacists face when managing diabetic patients who fast in Ramadan.

Design: A survey-based cross-sectional study.

Setting: A structured questionnaire was distributed online during April and May 2024.

Co-Loaded Nanoparticles of Empagliflozin and Rutin for Pancreatitis Prevention and Anticancer Activity.

Cancer treatment faces challenges like nonselective toxicity and drug resistance, prompting the need for innovative therapies. This study aimed to develop liposomal formulations for co-delivery of empagliflozin and rutin, evaluating their anticancer and antioxidant efficacy. PEGylated empagliflozin-loaded nanoliposomes (Empa-NLs) and empagliflozin-rutin co-loaded nanoliposomes (Empa-Rut NLs) were synthesized using the thin-film hydration technique.

Finger replantation in Jordan: evaluating the knowledge, attitudes, practices, and barriers among doctors and medical students.

Background: Finger replantation is a complex microsurgical procedure that requires optimal conditions for success. Understanding the knowledge and awareness of healthcare professionals regarding finger preservation and replantation can help improve outcomes for patients with amputated fingers.

Methods: A cross-sectional survey was conducted among healthcare professionals, including clinical years medical students, surgical residents, and specialists.

Identification of potential biomarkers of triton WR-1339 induced hyperlipidemia: NMR-based plasma metabolomics approach and gene expression analysis.

Background: Hyperlipidemia is a complex lipid metabolism disorder defined as an abnormal increase in circulating levels of one or more plasma lipids and lipoproteins. Triton WR-1339-induced hyperlipidemia model is one of the most commonly used acute models for hyperlipidemia induction in research. However, the metabolic alteration induced by Triton WR-1339 remains unclear.

The multifaceted effects of semaglutide: exploring its broad therapeutic applications.

Semaglutide, a GLP-1 receptor agonist, is FDA-approved for managing type 2 diabetes (T2D) and reducing cardiovascular risk. Its off-label use in weight management and other conditions has grown, prompting a review of its benefits and risks. This review evaluates evidence on semaglutide's effects, highlighting its therapeutic potential beyond approved indications.

The impact of the COVID-19 pandemic on home gardening practices in Irbid District, Jordan.

Home gardening has been instrumental in enhancing the self-sufficiency initiatives of families across the globe. Numerous researched emphasized the positive impacts of practicing home gardening throughout COVID-19. In Jordan, few studies were conducted to examine the influence of COVID-19 on various facets of life, including employment and the livelihoods of Jordanians, but no research had discussed the pandemic impacts on home gardening.

Shock Index as an indicator for blood transfusion or surgical intervention among multiple trauma patients in Jordan.

Trauma remains a leading cause of mortality worldwide, with uncontrollable bleeding contributing significantly to preventable deaths. This study assessed the utility of the shock index (SI) in predicting clinical outcomes in trauma patients. A retrospective analysis was conducted on 122 trauma patients admitted to King Abdullah University Hospital, Jordan.

Assessment of health-related quality of life in transfusion dependent beta thalassemia.

Research on health-related quality of life (HRQoL) among thalassemia patients in Jordan remains limited. This study aimed to evaluate HRQoL outcomes in patients with thalassemia and examine associations with psychosocial, medical, and clinical factors. A cross-sectional study was conducted among β-thalassemia major patients attending the Thalassemia Unit at Princess Rahma Educational Hospital for Children.

Assessing the Productivity of Colonies Headed by Preheated Honeybee Queens.

This study investigated the effects of preheat hardening on the egg-laying capacity of honeybee queens and the flight performance of their daughter workers. A honeybee queen was confined in a cage with a two-section frame for 12 h. Then, 48 h old eggs from one section were incubated for 15 min at 41 °C and 70% relative humidity (RH).

Epidemiology, antibiotic resistance, and molecular detection of blaOXA and blaCTX-M Genes in ESBL-Producing Escherichia coli from urinary tract infections in Jordanian hospitals.

Background: Urinary tract infections (UTIs) impose significant challenges among patients infected with multidrug-resistant Escherichia coli (E. coli). The emergence of the extended-spectrum beta-lactamase (ESBL) strains complicates the treatment and exacerbates life-threatening infections.

Evaluating the Association of Clinical Cardiovascular Parameters and Metabolic Indices With Levels of Cystatin C in Early Middle Age.

Background: The pathophysiology of renal dysfunction requires population-based study. It is debatable in the literature whether cardiovascular metrics have an impact on cystatin C levels.

Methods: Using public-use biomarkers data of The National Longitudinal Study of Adolescent to Adult Health (Add Health) Wave 5 data, we tested, after adjusting for age (range: 32-42), anthropometrics (body mass index, waist circumference, and arm circumference), hemoglobin A1C, low-density lipoprotein, triglyceride, smoking, and sex, the association of 5 clinical cardiovascular measures (systolic blood pressure, diastolic blood pressure, mean arterial pressure, pulse pressure, and pulse rate) with cystatin C levels.

Prevalence and reporting of adverse drug events among women in Jordan.

Objectives: To explore the occurrence and reporting of adverse drug events (ADEs) among women in Jordan.

Methods: This cross-sectional survey-based study was conducted over 3 months, utilizing a validated questionnaire distributed via social media platforms to Jordanian women aged 18 and older. Using SPSS version 26, the Chi-square and Fisher's exact tests to examine the association between ADE occurrences and participant demography were computed.

Interaction of Br with Cu(100) surface: adsorption and thermodynamics stability study.

The interaction between halogen species and metal surfaces plays a crucial role in numerous surface-driven processes. The adsorption behavior and thermodynamic stability of bromine (Br) atoms on the Cu(100) surface using density functional theory (DFT) with van der Waals (vdW) corrections and atomistic thermodynamics is investigated. Surface adsorption was analyzed across three high-symmetry sites-top, bridge, and hollow-at various coverages from (0.

Perceptions of Fungal Contamination in Hospital Humidifiers Among Healthcare Providers in Jordan: A Cross-Sectional Study.

Background: Hospital-acquired infections remain a critical concern globally. Fungal contamination of reusable hospital humidifiers, especially in intensive care units (ICUs), represents an under-recognized threat. These devices, if improperly maintained, may become reservoirs for opportunistic pathogens such as Aspergillus and Fusarium, thereby compromising patient safety.

Cucurbit[10]uril binding of heteroleptic iridium(iii) complexes: synthesis and photophysical characterization.

The supramolecular host-guest interaction between heteroleptic iridium(iii) complexes and cucurbit[10]uril (Q[10]) in an aqueous medium was investigated in this work. Both studied iridium complexes, [Ir(ppy)(bpy-(CHO))] (complex 1) and [Ir(ppy)(bpy-(COOH))] (complex 2), possessed two phenylpyridine ligands and a single R-bipyridine ligand. The formation of the encapsulated species (Q[10]·1 and Q[10]·2) was demonstrated by H NMR and luminescence studies.

Quality of Life Among School-Age Children With Type 1 Diabetes Mellitus: A Cross-Sectional Study.

Background: Ensuring good health and well-being for children requires a high quality of life (QOL). Sustainable development has led to the elimination of many chronic and epidemic diseases. QOL is a multifaceted system encompassing several dimensions, including social, physical, and psychological functioning, which has emerged as a necessary outcome for children with chronic disorders.

Memetic Salp Swarm Algorithm for economic load dispatch problems.

This paper presents a hybrid version of the Salp Swarm Algorithm (SSA) for Economic Load Dispatch (ELD) problems with severe constraints. The Adaptive β-hill climbing optimizer (AβHCO) ais hybridized with a newly developed local search method with SSA as a new operator. This hybridization scheme is known as a memetic algorithm, where SSA serves as a natural selection agent (general refinement) in a genotype environment, while AβHCO serves as a culture selection agent (local refinement) in a phenotype environment.

Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay.

Introduction: 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis. Elevated levels of 20-HETE are associated with hypertension. Accordingly, 20-HETE is a potential target for therapeutic interventions.

Correction: RvE1 attenuates polymicrobial sepsis-induced cardiac dysfunction and enhances bacterial clearance.

[This corrects the article DOI: 10.3389/fimmu.2020.

Sources and Predictors of Perceived Occupational Stress Among Nurses Working in Public Health Centers: A Cross-Sectional Study.

Objective: Nurses encounter increased occupational stress levels due to their involvement in patient care with intricate healthcare issues, influencing their physical and mental well-being. Thus, occupational stress is a major interest of health and nursing research. This study aimed to identify sources and predictors of occupational stress among public health nurses.

Reverse sural artery flap for lower extremity reconstruction: a multicenter retrospective analysis of success and failure patterns.

Background: The reverse sural artery flap (RSAF) has emerged as a versatile option for soft tissue reconstruction in the distal lower extremity, particularly when microsurgical expertise or resources are limited. Despite its increasing use, comprehensive multicenter data on its survival outcomes and anatomical site-specific performance remain limited.

Methods: This retrospective multicenter case series included all patients who underwent RSAF for distal lower extremity defects between 2015 and 2024 across military, governmental, private, and academic institutions.

Utilization of recovered vanadium pentoxide solution from a spent vanadium catalyst as an efficient electrolyte in an electric storage battery.

ObjectiveThe present investigation aims to utilize the extract of vanadium pentoxide from spent vanadium catalyst in a tabletop vanadium redox flow battery (VRFB) and a home-designed cell stack. The most commonly used redox couples in VRFB systems are V/V and V/V which typically require the use of costly VOSO standard solution. In this study we propose an alternatve approch by substituting these expensive solutions with more affordable and environmentally friendly option: a VO solution derived from spent catalyst.

Supramolecular complexation of locked-flavylium fluorescent dye by cucurbit[7]uril: photophysics and p modulation.

Herein, we studied the supramolecular host-guest complexation between cucurbit[7]uril (CB7) and a locked version of flavylium dye (LF) in aqueous solution. CB7 was able to form complexes with LF in its various protonation states as verified by UV-visible and fluorescence spectroscopy, revealing high binding affinities for the cationic and neutral form compared to the anionic one and resulting in complexation induced p shifts. The formation of inclusion complexation was established by H NMR and supported by DFT calculations.