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Pancreatic beta-cell secretory products in the diagnosis and risk stratification of gestational diabetes mellitus: a prospective longitudinal cohort study.
BMJ Open
September 2025
Neath Port Talbot Hospital, Port Talbot, Wales, UK.
Introduction: Gestational diabetes mellitus (GDM) is common in pregnancy and is increasing in prevalence. It is associated with an increased risk of maternal and perinatal complications if not diagnosed and managed early. Most guidelines suggest making a diagnosis of GDM using an oral glucose tolerance test (OGTT) between 24 and 28 weeks of pregnancy at which stage there still is an increased risk of complications.
View Article and Find Full Text PDFSystemic immune-inflammation index and risk of gestational diabetes and preeclampsia: a systematic review and meta-analysis.
J Obstet Gynaecol
December 2025
Obstetrics Ward 18/Huzhou Maternity & Child Health Care Hospital, Huzhou City, China.
Background: The systemic immune-inflammation index (SII) has been a marker and prognostic indicator of several diseases. However, its utility in pregnancy is unknown. Herein, we reviewed the evidence on the ability of SII to predict gestational diabetes mellitus (GDM) and preeclampsia (PE).
View Article and Find Full Text PDFCausal Associations Between Oral Microbiota and Gestational Diabetes Mellitus: A Two-Sample Mendelian Randomization Study.
Int J Womens Health
August 2025
Department of Internal Medicine, The Second People's Hospital of Nantong, Nantong, 226000, People's Republic of China.
Background: Gestational diabetes mellitus (GDM) is associated with adverse pregnancy outcomes. The oral microbiota, influenced by genetic factors, may play a role in GDM development, but the causal association remains unclear.
Methods: We employed a two-sample Mendelian randomization (MR) approach using Genome-Wide Association Study (GWAS) data on GDM from FINN cohort data (ID: finngen_R10_GEST_DIABETES) and GWAS data on the Oral microbiota from the Danish ADDITION-PRO cohort.
Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study.
Am J Hypertens
August 2025
Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.
Background: The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adulthood body size on GDM risk, and explore inflammation's role.
Methods: Using female-specific UK Biobank genome-wide association study data, genetic instruments for childhood/adult body size ("thinner," "about average," "plumper") and C-reactive protein (CRP) were identified.