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Article Abstract
Parallelization has revolutionized computing and DNA sequencing but remains largely unexploited in mass spectrometry (MS), which typically analyzes ions sequentially. We introduce a nature-inspired ion trap (MultiQ-IT) that enables massively parallel MS. The device comprises a cubic array of small quadrupoles forming multiple ion entry and exit ports, allowing >10⁹ ions to be confined and manipulated simultaneously. This architecture enables selective depletion of singly charged ions in real time, greatly improving signal-to-noise ratios and detection sensitivity. The trap also functions as a parallel ion splitter, transmitting ions into multiple m/z-specific beams. We demonstrate scalable ion throughput, real-time charge discrimination, and parallel beam separation, suggesting a path toward truly parallel MS. Our results offer a foundation for next-generation, high-throughput proteomic and metabolomic analyses.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407793 | PMC |
| http://dx.doi.org/10.1101/2025.08.21.671534 | DOI Listing |
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Parallelization has revolutionized computing and DNA sequencing but remains largely unexploited in mass spectrometry (MS), which typically analyzes ions sequentially. We introduce a nature-inspired ion trap (MultiQ-IT) that enables massively parallel MS. The device comprises a cubic array of small quadrupoles forming multiple ion entry and exit ports, allowing >10⁹ ions to be confined and manipulated simultaneously.
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