[Volumetry of the olfactory bulb - One component in the objectification of disorders of the sense of smell].

HNO

Klinik für diagnostische und interventionelle Radiologie und Neuroradiologie, Bundeswehrzentralkrankenhaus Koblenz, Rübenacher Str. 170, 56072, Koblenz, Deutschland.

Published: September 2025


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Disorders of olfaction are a frequent reason for an assessment in otorhinolaryngology. Particularly when the results of subjective and/or objective olfactometry are inconclusive, additional objective findings are required to verify disorders of the sense of smell. Based on practical experience and considering the current literature, this article is intended as an aid in the preparation of supplementary radiological reports. The importance of comprehensive up to date standard imaging including olfactory bulb volumetry in addition to a detailed medical history and, if applicable, previous findings should be emphasized. In addition to the documentation of alterations in the anatomical structures involved in olfaction, which support the reported disorders in the sense of smell, special neuroradiological examination sequences for the visualization of the olfactory bulb, including a volumetric measurement of the same, can provide an objective component for the assessment of sometimes only subjectively existing disorders of the sense of smell. In the majority of cases no valid comparative volumetry can be derived from a possibly pre-existing imaging study. Therefore, a comparison with olfactory bulb reference values, determined in studies for the presumed etiology and the extent of the disorder reported/determined by olfactometry is the only way to put the olfactory bulb volume in an almost objective relationship to the function of the sense of smell reported and/or determined by olfactometry.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00106-025-01650-zDOI Listing

Publication Analysis

Top Keywords

disorders sense
16
sense smell
16
olfactory bulb
16
disorders
5
sense
5
[volumetry olfactory
4
olfactory bulb -
4
bulb - component
4
component objectification
4
objectification disorders
4

Similar Publications

Dopamine (DA) signaling is essential for neurodevelopment and is particularly sensitive to disruption during adolescence. Protein restriction (PR) can impair DA dynamics, yet mechanistic insights remain limited due to challenges in real-time neurochemical sensing. Here, we present aptCFE, a robust implantable aptamer-based sensor fabricated via a reagent-free, 3 min electrochemical conjugation (E-conjugation) using amine-quinone chemistry.

View Article and Find Full Text PDF

In this study, employing a 2D electrodeposition in situ assembly method, a high-performance HS sensor based on a p-n type CuO-CuFeO heterostructure ordered nanowire arrays was successfully fabricated on silicon substrates. Compared to CuO, CuO-CuFeO nanowire arrays exhibits an ideal interfacial barrier structure and higher initial resistance, with a response to 10 ppm of HS at room temperature (20 ± 3 °C) increased by 225 times and a response time reduced by over 2400 s. The sensor demonstrates exceptional sensitivity (LOD = 10 ppb; response = 234.

View Article and Find Full Text PDF

The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo channels resulted in an explosion of research exploring the translation of mechanical cues into biochemical signals and dynamic cell morphology responses. One of the Piezo isoforms - Piezo1 - is integral in the erythrocyte (red blood cell; RBC) membrane.

View Article and Find Full Text PDF

Living with temperature changes: Salicylic acid at the crossroads of plant immunity and temperature resilience.

Sci Adv

September 2025

Key Laboratory of Soybean Disease and Pest Control (Ministry of Agriculture and Rural Affairs), Key Laboratory of Plant Immunity, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China.

Salicylic acid (SA) is a key defense hormone shaped by temperature. High temperatures suppress, while low temperatures enhance, SA biosynthesis and signaling, thereby influencing plant immunity and temperature resilience. This review synthesizes current understanding of how temperature modulates SA pathways and their cross-talk with other hormones to balance growth and defense.

View Article and Find Full Text PDF

Cardiovascular diseases (CVDs) remain a leading cause of death, particularly in developing countries, where their incidence continues to rise. Traditional CVD diagnostic methods are often time-consuming and inconvenient, necessitating more efficient alternatives. Rapid and accurate measurement of cardiac biomarkers released into body fluids is critical for early detection, timely intervention, and improved patient outcomes.

View Article and Find Full Text PDF