Understanding human embryogenesis by building programmable stem cell-based models.

Trends Cell Biol

Department of Biomolecular Engineering, University of California Santa Cruz, Santa Cruz, CA, USA; Genomics Institute, University of California Santa Cruz, Santa Cruz, CA, USA; Institute for the Biology of Stem Cells, University of California Santa Cruz, Santa Cruz, CA, USA. Electronic address: alish

Published: September 2025


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Article Abstract

Stem cell-based embryo models provide an alternative system to study an elusive period of development. Programmed mouse embryo models have recently been generated by activating two endogenous regulatory elements via epigenome editing. In this forum article, we discuss this achievement along with the potential of translating it to engineering models of human embryogenesis.

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http://dx.doi.org/10.1016/j.tcb.2025.08.003DOI Listing

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