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Background: Fibromyalgia (FM) and trigeminal neuralgia (TN) are commonly mistreated pain diagnoses that often present significant cognitive-affective impairments. .
Case Report: A 22-year-old woman with diagnoses of FM and TN underwent 5 sessions of 2 mA transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex for 20 minutes followed by ~20 minutes of pain neuroscience education (PNE). Following 5 sessions, the patient reported resolution of TN-related symptoms and improvement of generalized pain, fatigue, and sensitivity. The patient demonstrated a 60% reduction in self-reported pain, 65% in pain catastrophizing, 24% in kinesiophobia, 28% in central sensitization, and 33% improvement in attentional interference.
Conclusion: The case study demonstrates positive effect of tDCS and PNE in the management of FM and TN. Interventions primarily targeted the cognitive-affective domains of pain, improving both cognitive-affective and sensory outcomes. tDCS + PNE may provide a novel combination of intervention for 2 historically ill-treated conditions.
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J Drug Target
September 2025
Neuroscience Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Background: Chronic constriction injury (CCI) of the sciatic nerve induces neuropathic pain, inflammation, oxidative stress, and neurodegenerative changes, impairing sensory and emotional function. While curcumin is well recognized for its anti-inflammatory and neuroprotective properties, its therapeutic use is limited by poor bioavailability. Curcumin liposomal nanoparticles (CLNs) offer improved delivery and stability.
View Article and Find Full Text PDFActa Neurol Belg
September 2025
Neuroscience Research Australia, University of New South Wales, Sydney, Australia.
Objectives: Patients diagnosed with amyotrophic lateral sclerosis (ALS) typically describe symptoms of fatigue. Despite this frequency, the underlying mechanisms of fatigue are poorly understood, and are likely multifactorial. To help clarify mechanisms, the present systematic review was undertaken to determine the risk factors related to fatigue in ALS.
View Article and Find Full Text PDFAnesthesiology
October 2025
Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts; Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts.
Despite the widespread use of clinical anesthesia, the process of emergence from general anesthesia remains primarily driven by anesthetic elimination. Although emergence from general anesthesia is typically safe, prolonged delays strain resource-intensive settings and contribute to increased healthcare costs. In addition to improving access to care, providing clinicians with more precise control over emergence could offer diagnostic potential and improve patient outcomes.
View Article and Find Full Text PDFAnesthesiology
October 2025
Department of Anesthesiology, Pharmacology, Intensive Care and Emergency Medicine, University Hospital of Geneva, Geneva, Switzerland; Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland.
Neurosurgery
September 2025
Department of Neurosurgery, John Radcliffe Hospital, Oxford, UK.
Background And Objectives: Chiari 1 malformation (CM1) is a common MRI finding and a frequent reason for neurosurgical consultation. Although many studies have investigated surgical outcomes for patients with CM1, outcomes for those treated without surgery have been less frequently reported. The UK Chiari 1 Study reports the quality of life of adults and children with CM1 treated without surgery, 12 months after the first neurosurgical clinic visit.
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