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Article Abstract

Primary adrenal melanoma is an exceedingly rare diagnosis. We present a case of primary left adrenal melanoma with rapid and extensive distant metastasis. The patient underwent a biopsy of the left adrenal tumor, and pathological analysis confirmed malignant melanoma. Immunohistochemical staining revealed positive cytoplasmic reactivity for Melan A, HMB45, and SOX-10. We also review relevant cases reported in the English literature and discuss the diagnostic criteria, differential diagnoses, and potential management strategies.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12390801PMC
http://dx.doi.org/10.3389/fonc.2025.1654218DOI Listing

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