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The robustness and accuracy of multi-organ segmentation networks is limited by the scarcity of labels. A common strategy to alleviate the annotation burden is to use partially labelled datasets, where each image can be annotated for a subset of all organs of interest. Unfortunately, this approach causes inconsistencies in the background class since it can now include target organs. Moreover, we consider the even more relaxed setting of region-based segmentation, where voxels can be labelled for super-regions, thus causing further inconsistencies across annotations. Here we propose CoNeMOS (Conditional Network for Multi-Organ Segmentation), a framework that leverages a label-conditioned network for synergistic learning on partially labelled region-based segmentations. Conditioning is achieved by combining convolutions with expressive Feature-wise Linear Modulation (FiLM) layers, whose parameters are controlled by an auxiliary network. In contrast to other conditioning methods, FiLM layers are stable to train and add negligible computation overhead, which enables us to condition the entire network. As a result, the network can where it needs to extract shared or label-specific features, instead of imposing it with the architecture (e.g., with different segmentation heads). By encouraging flexible synergies across labels, our method obtains state-of-the-art results for the segmentation of challenging low-resolution fetal MRI data. Our code is available at https://github.com/BBillot/CoNeMOS.
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Int J Antimicrob Agents
September 2025
Dalle Molle Institute for Artificial Intelligence IDSIA. USI/SUPSI, Via la Santa 1, CH-6962 Lugano-Viganello, Switzerland. Electronic address:
Cell-penetrating peptides (CPPs) are powerful vectors for the intracellular delivery of a diverse array of therapeutic molecules. Despite their potential, the rational design of CPPs remains a challenging task that often requires extensive experimental efforts and iterations. In this study, we introduce an innovative approach for the de novo design of CPPs, leveraging the strengths of machine learning (ML) and optimization algorithms.
View Article and Find Full Text PDFJ Phys Chem Lett
September 2025
Hunan Key Laboratory of Nanophotonics and Devices, Hunan Key Laboratory of Super Microstructure and Ultrafast Process, School of Physics, Central South University, Changsha, Hunan 410083, China.
The optoelectronic properties of perovskite/two-dimensional (2D) material van der Waals heterojunctions provide greater potential for innovative neuromorphic devices. However, the traditional growth of heterojunctions still relies on strict lattice matching and high-temperature processes, which hinder high-quality interface construction and efficient carrier transport. Here, the 2D CsPbI/MoS heterojunction is realized via the van der Waals epitaxy process, overcoming lattice matching limitations.
View Article and Find Full Text PDFPLoS One
September 2025
School of Design and Art, Hunan University, Changsha, Hunan, China.
This study addresses the limitations of traditional interior space design, particularly the timeliness and uniqueness of solutions, by proposing an optimized design framework that integrates a two-stage deep learning network with a single-sample-driven mechanism. In the first stage, the framework employs a Transformer network to extract multi-dimensional features (such as spatial layout, color distribution, furniture style, etc.) from input space images, generating an initial feature vector.
View Article and Find Full Text PDFLangmuir
September 2025
Department of Light Chemical Engineering, School of Textiles Science and Engineering; Key Laboratory of Special Protective, Ministry of Education; Jiangnan University, Wuxi 214122, P. R. China.
Polymerizable deep eutectic solvents (PDES) have recently emerged as a class of solvent-free ionically conductive elastomers and are considered among the most feasible candidates for next-generation ionotronic devices. However, the fundamental challenge persists in synergistically combining high mechanical strength, robust adhesion, reliable self-healing capacity, and effective antimicrobial performance within a unified material system capable of fulfilling the rigorous operational demands of next-generation ionotronic devices across multifunctional applications. Inspired by the hierarchical structure of spider silk, HCAG eutectogels composed of acrylic acid (AA), 2-hydroxyethyl acrylate (HEA), and choline chloride (ChCl) were successfully synthesized via a one-step photopolymerization method.
View Article and Find Full Text PDFFood Chem X
August 2025
College of Light Industry and Food Engineering, Guangxi University, Nanning, 530004, China.
This study utilized integrated sensory-guided, machine learning, and bioinformatics strategies identify umami-enhancing peptides from , investigated their mechanism of umami enhancement, and confirmed their umami-enhancing properties through sensory evaluations and electronic tongue. Three umami-enhancing peptides (APDGLPTGQ, SDDGFQ, and GLGDDL) demonstrated synergistic/additive effects by significantly enhancing umami intensity and duration in monosodium glutamate (MSG). Furthermore, molecular docking showed that these umami-enhancing peptides enhanced both the binding affinity and interaction forces between MSG and the T1R1/T1R3 receptor system, thereby enhancing umami perception.
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