Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Objective: Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead to airway narrowing, which is an important factor in asthma. This study explores the potential impact of Ranolazine, a sodium blocker used for chronic angina, on asthmatic rats. By investigating the drug's effects on vascular and lung tissue changes, this research seeks to offer perspectives on innovative treatment approaches for asthma.
Results: Ranolazine treatment showed minimal impact on serum IgE levels in asthmatic rats, with a slight reduction that was statistically insignificant. However, Ranolazine treatment resulted in a significant decrease in perivascular and peribronchial inflammation levels compared to the asthmatic group, suggesting a potential therapeutic effect on lung histology changes associated with asthma pathophysiology.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398087 | PMC |
| http://dx.doi.org/10.1186/s13104-025-07455-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Point Application Therapy Targeting Feishu, Pishu and Shenshu Attenuates Asthma by Suppressing Autophagy and the AMPK-mTOR Signalling Pathway.
J Asthma
September 2025
Department of Acupuncture and Moxibustion, the First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou 310006, China.
Objective: In traditional Chinese medicine, asthma is associated with deficiencies in Lung Qi, Spleen Qi, and Kidney Qi. This study investigated the therapeutic mechanism of point application therapy focusing on the acupoints Feishu (BL13), Pishu (BL20), and Shenshu (BL23) for asthma treatment.
Methods: An asthma model was established in Wistar rats via intraperitoneal ovalbumin injection combined with nebulisation.
Yanghe Pingchuan granules inhibit cellular senescence in airway smooth muscle cells to improve bronchial asthma via modulating Nrf2 acetylation.
Respir Res
August 2025
The First Affiliated Hospital of Anhui University of Chinese Medicine, NO.117 Meishan Road, Shushan District, Hefei, 230031, Anhui, China.
Background: Bronchial asthma (BA) is regarded as one of the most prevalent chronic respiratory diseases worldwide. Yanghe Pingchuan Granules (YPG), a traditional Chinese medicine (TCM) compound, has been employed extensively in treating BA. However, the precise mechanism by which it exerts its therapeutic effects remains to be fully elucidated.
View Article and Find Full Text PDFInvestigating the effect of Ranolazine drug on the pathophysiology of asthma in a rat model.
BMC Res Notes
August 2025
Cancer Gene therapy Research Center, Zanjan University of Medical Science, Zanjan, Iran.
Objective: Asthma is a common multifactorial inflammatory disease affecting both children and adults. Various cells and cytokines contribute to this inflammatory process. Smooth muscle contraction, vascular congestion, and airway edema lead to airway narrowing, which is an important factor in asthma.
View Article and Find Full Text PDFPhytochemical profile, toxicological evaluation, and therapeutic potential of the ethanolic extract of Combretum leprosum Mart. stem bark in an ovalbumin-induced asthma model in rats.
J Ethnopharmacol
August 2025
Postgraduate Program in Pharmacology, Federal University of Piauí, Teresina, PI, Brazil; Medicinal Plants Research Center, Federal University of Piauí, Teresina, PI, Brazil. Electronic address:
Ethnopharmacological Relevance: Medicinal plants are widely used in traditional medicine to treat various diseases, especially in communities with limited access to conventional healthcare. Among these, Combretum leprosum Mart. (Combretaceae), popularly known as "mofumbo," holds a prominent place in Brazilian folk medicine, where it is traditionally used to treat respiratory conditions such as asthma and cough.
View Article and Find Full Text PDFInvestigating the Underlying Mechanisms of Ma-Xing-Shi-Gan-Tang on Asthma via Metabolomics and Network Pharmacology.
J Inflamm Res
August 2025
College of Medicine, Lishui University, Lishui, 323000, People's Republic of China.
Objective: Ma-xing-shi-gan-tan (MXSGT) was first published in "Shang-han-lun". It functions as a heat-clearing agent, lung-clearing formula, and asthma reliever. This study aims to evaluate the therapeutic effect of MXSGT on asthma and elucidate its underlying mechanisms.
View Article and Find Full Text PDF