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Opinion mining is more challenging than it was before because of all the user-generated material on social media. People use Twitter (X) to gather opinions on products, advancements, and laws. Sentiment Analysis (SA) examines people's thoughts, feelings, and views on numerous topics. Tweets can be analyzed to determine public opinion on news, regulations, society, and personalities. The existing SA system has poor prediction performance and needs improvements for instantaneous commercial applications. The insufficient data and complexity of model configuration, which make deep learning (DL) difficult, are the main causes of low accuracy and prediction rates. Convolutional Neural Long Short-Term Memory (OTCNLSTM) optimal tiered blocks with classification learning are proposed in this research to recognize emotions. The objective is to classify tweets as happy or sad. The TCNLSTM model consists of four training blocks for local features. These blocks are designed to extract local emotions hierarchically. The Boosted Killer Whale Predation (BKWOP) strategy is implemented to find the appropriate hyperparameter and its solution set and build a stable neural network model. This research reviews textual emotional classification experiments utilizing various sentiment models and methods. To further analyze this research, a comparative experimental study using the Kaggle Twitter dataset is conducted. The results indicate that the OTCNLSTM model had superior performance compared to the other models.
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http://dx.doi.org/10.1038/s41598-025-16927-0 | DOI Listing |
Front Immunol
September 2025
Department of Geriatrics, Jilin Geriatrics Clinical Research Center, The First Hospital of Jilin University, Changchun, Jilin, China.
Kaempferol (KMF) is a dietary flavonoid exhibiting profound immunomodulatory effects across multiple immune cell populations. This review synthesizes current insights into how KMF regulates diverse immune cell populations and its therapeutic potential in inflammatory and immune-related disorders. KMF exhibits multifaceted effects on T cells.
View Article and Find Full Text PDFSci Rep
August 2025
College of Engineering and Technology, Department of Computer Science, Dilla University, Po. Box 419, Dilla, Ethiopia.
Opinion mining is more challenging than it was before because of all the user-generated material on social media. People use Twitter (X) to gather opinions on products, advancements, and laws. Sentiment Analysis (SA) examines people's thoughts, feelings, and views on numerous topics.
View Article and Find Full Text PDFJ Hepatocell Carcinoma
August 2025
Department of Medical Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, People's Republic of China.
Background: Hepatocellular carcinoma (HCC) is a prevalent lethal cancer that remains challenging to treat. Therefore, investigation of novel targets and therapeutic strategies is essential. The role of ZBED4 in cancer remains unclear.
View Article and Find Full Text PDFFront Immunol
August 2025
Research Institute, Qingdao Restore Biotechnology Co., Ltd., Qingdao, Shandong, China.
Immunotherapy has emerged as the established fourth pillar of cancer treatment following surgery, radiotherapy, and chemotherapy, representing a cutting-edge research domain in translational medicine and clinical oncology. Natural killer (NK) cells, a type of innate cytotoxic lymphocyte, possess unique antitumor properties that are independent of major histocompatibility complex (MHC) restrictions, making them promising candidates for "off-the-shelf" therapeutic products. NK cells can eliminate tumor cells through various mechanisms.
View Article and Find Full Text PDFJ Mol Histol
August 2025
Department of proctology, Wenling TCM Hospital Affiliated to Zhejiang Chinese Medical University (Wenling Hospital of Traditional Chinese Medicine), No. 21, Mingyuan Road, Taiping Street, Wenling, 317500, Zhejiang, China.
Colorectal cancer progression involves tumor metastasis and immune evasion, with the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome and Natural Killer Group 2D (NKG2D) signaling pathway playing key roles. Their relationship in regulating NK cell-mediated cytotoxicity and CRC progression remains unclear. This study investigates NLRP3's modulation on tumor dynamics and NK cell responses to uncover new therapeutic targets.
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