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Background: Remote monitoring (RM) is the standard of care for patients with cardiac implantable electronic devices (CIEDs). Data deluge from RM of CIEDs is one of the major challenges being faced by cardiac device clinics.
Objectives: The purpose of this study was to highlight the role of artificial intelligence (AI) in reducing data deluge from CIEDs and to elucidate its performance in augmenting the traditional device clinic workforce.
Methods: Deidentified data from RM of CIEDs from 78 device clinics across the United States were included. Transmissions processed by AI and device technicians (DTs) were compared. Around 15% of all transmissions processed were examined at random by 2 cardiac electrophysiologists who were blinded to the source of the interpretation.
Results: Over 8 months, 690,673 transmissions were generated from RM of 74,217 devices. AI processed 28.3% of the transmissions, whereas DT processed 71.7% (n = 495,054). AI forwarded 22.8% (n = 44,550) while DT forwarded 38.5% (n = 190,492) of the total processed transmissions to the device clinics. As such, only 34% (n = 235,042) of the total transmissions were forwarded to the device clinics. Considering electrophysiologist interpretation/adjudication as the gold standard, AI was 93.8% accurate with 99.1% sensitivity, 93% specificity, and an F1 score of 81%.
Conclusions: This study presents a real-world analysis of incorporating AI in device clinic workflow to assist in interpretation and classification of RM data. AI interpretation of transmissions was found to have an accuracy similar to that of DT with superior sensitivity but lesser specificity.
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http://dx.doi.org/10.1016/j.jacadv.2025.102057 | DOI Listing |
Mol Phylogenet Evol
September 2025
School of Ecology and Environmental Science, Yunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology and Institute of Biodiversity, School of Life Sciences, Yunnan University, Kunming 650504 Yunnan, China. Electronic address:
The advent of high-throughput genomic sequencing has provided unprecedented access to genome-scale data. This deluge of data has yielded new insights into phylogenetic relationships across the tree of life. However, incongruent results arising from different data partitions or from the use of different analyses have often been overlooked or insufficiently explored.
View Article and Find Full Text PDFJACC Adv
August 2025
Kansas City Heart Rhythm Institute, HCA Midwest Health, Overland Park, Kansas, USA. Electronic address:
Background: Remote monitoring (RM) is the standard of care for patients with cardiac implantable electronic devices (CIEDs). Data deluge from RM of CIEDs is one of the major challenges being faced by cardiac device clinics.
Objectives: The purpose of this study was to highlight the role of artificial intelligence (AI) in reducing data deluge from CIEDs and to elucidate its performance in augmenting the traditional device clinic workforce.
Sci Rep
July 2025
Department of Computer Science and Engineering, Model Institute of Engineering and Technology, Jammu, Jammu and Kashmir, India.
As the field of single-cell genomics continues to develop, the generation of large-scale scRNA-seq datasets has become more prevalent. Although these datasets offer tremendous potential for shedding light on the complex biology of individual cells, the sheer volume of data presents significant challenges for management and analysis. Off late, to address these challenges, a new discipline, known as "big single-cell data science," has emerged.
View Article and Find Full Text PDFInnovation (Camb)
July 2025
Luthra & Luthra Law Offices India, Barakhamba Road, New Delhi 110001, India.
Bioinformatics
July 2025
GenBio AI, MBZUAI, Abu Dhabi, United Arab Emirates.
Motivation: As one of the recalcitrant challenges in life sciences and biomedicine, protein function prediction suffers from a deluge of AI-designed proteins, particularly having to face multi-modal information in the era of big data. Importing the high-throughput neural-network-based prediction framework to replace the low-throughput biological experiments, a universal multi-modal method is straightforward in addressing the growing gap between known sequences and predicting functions.
Results: To bridge the gap, we propose ProtGO, a three-step framework for predicting protein function, which leverages the credible Gene Ontology (GO) knowledge base and integrates four common modalities.