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Controlling light to multiple focal locations through complex scattering media is becoming increasingly significant in various realms. Although wavefront shaping (WFS) has been demonstrated as a promising solution to counteracting optical scattering, current WFS methods for multifocal control through scattering media suffer from low focal quality, extensive measurements, or complexity of system configurations and signal reconstructions. Here, we report a WFS concept, called binary-intensity-synthetic digital optical phase conjugation (BIS-DOPC), to mitigate these drawbacks. The BIS-DOPC records a single on-axis speckle interferogram of the scattered light originating from a movable guidestar and superimposes the interferograms from multiple predefined guidestar locations to create an "intensity-synthetic" interferogram. We find that the light with a wavefront corresponding to a binarized version of the synthetic intensity map converges to all the guidestar locations through scattering media. The good focal quality, reduced measurement requirements, and simplicity of system configuration, data acquisition, and processing make BIS-DOPC an attractive solution for multifocal control through scattering media.
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http://dx.doi.org/10.1364/OL.571788 | DOI Listing |
Int J Nanomedicine
September 2025
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, Jiangsu, People's Republic of China.
Introduction: Oral squamous cell carcinoma (OSCC) has a poor prognosis due to its immunosuppressive tumor microenvironment (TME), in which tumor-associated macrophages (TAMs) play a pivotal role in promoting disease progression and therapeutic resistance. This study examines whether Prussian blue nanoparticles (PB NPs) could reprogram TAMs and block tumor-stroma communication in OSCC.
Methods: PB NPs were synthesized using polyvinylpyrrolidone-assisted coprecipitation and characterized by transmission electron microscopy, dynamic light scattering, and UV-Vis spectroscopy.
Small
September 2025
South China Advanced Institute for Soft Matter Science and Technology, School of Emergent Soft Matter, Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices, Guangdong Basic Research Center of Excellence for Energy and Information Polymer Materials, South Chi
Self-assembled poly(2-dimethylaminoethyl methacrylate)-poly(2-(diisopropylamino)ethyl methacrylate) (PDMA-PDPA) diblock copolymer nanoparticles are widely employed in biological applications, driving the need for a robust and scalable production method. Although polymerization-induced self-assembly (PISA) enables efficient nanoparticle synthesis at high solids content, its research and application to PDMA-PDPA are limited, likely due to kinetic trapping. Leveraging our recently developed generic time-resolved small-angle X-ray scattering (TR-SAXS) approach for PISA in non-polar media, a reversible addition-fragmentation chain transfer-mediated PDMA-PDPA PISA process in polar solvent that produces spherical micelles is examined.
View Article and Find Full Text PDFTher Adv Infect Dis
September 2025
University of Utah Hospital, Salt Lake City, UT, USA.
A 79-year-old female diagnosed with myelodysplastic syndrome (MDS) and germline GATA2 mutation, on compassionate cobimetinib, was admitted with subacute cough and dyspnea. Chest imaging demonstrated a new, large, left hilar mass and consolidation with scattered diffuse mediastinal, supraclavicular, and hilar lymphadenopathy. A core biopsy of the right supraclavicular lymph node was performed.
View Article and Find Full Text PDFACS Omega
August 2025
Philadelphia College of Pharmacy, Department of Pharmaceutical Sciences, Saint Joseph's University, 600 S. 43rd St, Philadelphia, Pennsylvania 19104, United States.
Due to high drug loading and effective cell permeability, single-walled carbon nanotubes (SWCNTs) are promising nanocarriers for drug delivery systems. However, SWCNTs tend to aggregate in dispersion media because of their high aspect ratio and intrinsic hydrophobicity. Thus, the dispersion and stability of SWCNTs in water strongly depend on the dispersion method and CNT surface characteristics.
View Article and Find Full Text PDFSurface-enhanced Raman scattering (SERS) spectroscopy represents a powerful analytical platform that combines non-destructive, label-free molecular identification with exceptional sensitivity for trace-level detection. Its capacity to generate information-rich spectral fingerprints makes SERS particularly advantageous for simultaneous multi-analyte analysis across diverse sample matrices, including complex biological systems. This study addresses the analytical challenges associated with identifying and quantifying multiple molecular species in complex environments by integrating SERS with advanced machine learning methodologies.
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