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Article Abstract
Antimicrobial resistance (AMR) has emerged as a critical global health challenge, necessitating urgent development of novel antimicrobial agents. Pyrrolo[2,3-]pyrimidine derivatives have garnered substantial research interest in pharmaceutical chemistry owing to their structural diversity, synthetic accessibility, and broad-spectrum bioactivity. This comprehensive review presents and discusses recent advancements in pyrrolo[2,3-]pyrimidine research, focusing on methodological innovations in scaffold construction. Key synthetic strategies, including [3 + 2] cycloadditions, transition metal-catalyzed couplings, and microwave-assisted ring closure techniques, are highlighted. Additionally, a thorough discussion of their antimicrobial activities is presented, encompassing antibacterial, antifungal, and antiviral effects. This review provides valuable insights into the rational design and synthesis of novel pyrrolo[2,3-]pyrimidine derivatives. These contributions may facilitate the development of new antimicrobial agents to address evolving resistance.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12379008 | PMC |
| http://dx.doi.org/10.1039/d5ra03313f | DOI Listing |
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