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http://dx.doi.org/10.3389/fimmu.2025.1667375 | DOI Listing |
Ther Adv Infect Dis
September 2025
Department of Medicine, Division of Infectious Diseases, and Department of Microbiology and Immunology, Stony Brook University, 101 Nicolls Rd, HSC16-027 J, Stony Brook, NY 11794, USA.
Background: Fascioliasis, caused by and , is a neglected tropical disease that has significant medical and veterinary importance. This foodborne zoonotic trematodiases primarily affects poor rural populations in tropical and subtropical areas, where prevalence can be as high as 21%.
Objective: This study aims to characterize the clinical features, laboratory findings, and outcomes of fascioliasis in a real-world cohort.
Essays Biochem
September 2025
Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, China.
The intricate regulation of the immune system, maintaining equilibrium between pathogen defense and self-tolerance, is fundamental to health. Disruptions in this delicate balance underlie a vast spectrum of human diseases, extending beyond oncology to encompass autoimmune disorders, chronic inflammatory conditions, infectious diseases, allergies, and hypertension. While traditional therapies often rely on broad immunosuppression or direct pathogen eradication, the rapidly evolving field of immunomodulation offers a nuanced alternative: precisely calibrating immune responses to restore homeostasis or achieve targeted defense.
View Article and Find Full Text PDFFront Vet Sci
August 2025
Immunology Unit, Department of Physiology, Faculty of Veterinary, Universidad de Extremadura, Cáceres, Spain.
Virtual laboratories provide a risk-free environment for students to conduct experiments, particularly those involving hazardous materials or complex procedures. Previous studies have shown that gamified elements and interactive tools enhance the interest of students and promote active participation. In the case of Immunology in the veterinary degree, our prior observations indicate that veterinary students experience learning difficulties with topics related to molecules and effector functions of the immune system.
View Article and Find Full Text PDFFront Nucl Med
August 2025
School of Health Sciences and Social Work, Griffith University, Brisbane/Gold Coast, QLD, Australia.
Background: Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [C]DPA713 uptake in the spinal cord and neuroforamina in patients with painful cervical radiculopathy, (2) evaluate the performance of linearized methods (e.
View Article and Find Full Text PDFFront Pharmacol
August 2025
Department of Ophthalmology and Visual Sciences, University of Illinois Chicago, Chicago, IL, United States.
4-Phenylbutyrate (4-PBA), initially recognized for treating urea cycle disorders, has emerged as a potent therapeutic agent with broad-spectrum potential. As a chemical chaperone, 4-PBA modulates protein folding and reduces endoplasmic reticulum stress. 4-PBA has demonstrated efficacy in treating ocular herpes simplex virus type 1 (HSV-1) infection and HSV-1-induced encephalitis, highlighting its potential as a novel anti-herpetic therapy.
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