Layer-by-Layer Assembled Perovskite/Polymer Photoelectrochemical Devices with Enhanced Performance and Stability.

Organic-inorganic hybrid perovskites (OIHPs) offer a promising pathway for the development of low-cost and efficient solar hydrogen production systems. Despite remarkable advancements, poor chemical stability of the OIHPs in aqueous environments limits their practical applications. Herein, we design a photoelectrochemical (PEC) device consisting of layer-by-layer assembled P(VDF-TrFE)/CHNHPbBr (MAPbBr) hybrid films that simultaneously achieve efficient and stable solar water splitting.

Psychosocial correlates in cases of marital discord: A cross-sectional study.

Background: Marital discord is associated with adverse psychosocial outcomes not just for the couple but also for their children. Identifying psychosocial risk factors can help devise targeted interventions. This study aimed to determine the psychosocial correlates of marital discord through a cross-sectional design.

Variations in the Branching Pattern of the Aortic Arch Among Adults and Its Clinical Correlations: A Computed Tomographic Angiographic Study.

Background: Variations can occur in the branching pattern of the aortic arch (AA) because of its complex embryological development. These variations are quite common and typically asymptomatic but can sometimes cause dyspnea, dysphagia, and intermittent claudication, as well as confusion in the interpretation of radiological scans.

Methods: In the present study, we analyzed the types and incidence of AA variations in 105 patients after careful computed tomographic angiographic (CTA) imaging.

Dissipation pattern, risk assessment and decontamination of residues of emamectin benzoate, fipronil and acetamiprid on bell pepper.

Present investigation evaluated the persistence of emamectin benzoate, fipronil, and acetamiprid in bell pepper fruits and soil, their dietary risks, and the effectiveness of decontamination methods. Initial residues at the X dose were 0.045, 1.

Measuring the cochlea: comparison between otoplan and curved multiplanar reconstruction and literature review.

Objectives: To compare two high-resolution computerised tomography based pre-surgical planning software in measuring the cochlear dimensions, which can aid in designing/choosing customised cochlear implant electrodes.

Methods: A cross-sectional-observational study was conducted in a tertiary care centre using high-resolution computerised tomography-supported software Otoplan and curved multi-planar reconstruction to find cochlear duct length's maximum and minimum width/diameter and height in 110 ears (55 subjects). Measurements and the time taken by both techniques were compared.

Endotracheal Intubation Comparing Airtraq and McCoy Laryngoscope in Patients with Simulated Cervical Spine Immobilization.

Objectives: Sniffing position for laryngoscopy requires flexion of the lower and extension of upper cervical spine and atlanto-occipital joint. Laryngoscopy is challenging in cervical spine pathology. This study was conducted to compare Airtraq with McCoy for ease of intubation in patients with simulated cervical immobilization.

In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism.

Polydatin (PD), a stilbenoid resveratrol-derivative in Vitaceae, Liliaceae, and Leguminosae, exhibits pharmacological protection in metabolic disorders. This study investigated Polydatin, as a potential pan-PPAR agonist for treating non-alcoholic fatty liver disease (NAFLD). High-throughput-virtual-screening (HTVS) was performed to identify potential pan-PPAR agonists, followed by in vitro testing of Polydatin in HepG2 steatosis model.

Design and optimization of PLGA-based gemcitabine nanocapsule for enhanced pancreatic cancer efficacy.

This study aimed to develop gemcitabine-loaded nanocapsules for pancreatic cancer treatment, optimizing their formulation before evaluating them through in vivo studies. The researchers selected gemcitabine as the model drug because it has established clinical relevance and known pharmacokinetic shortfalls (short half-life and poor bioavailability) with toxic dose limits which suit the evaluation of nanoparticle drug delivery systems. The researchers conducted a 3 factorial design to optimize the formulation through adjustments of PLGA concentration and Tween 80 concentration.

Synergistic evaluation of anti-diabetic and hypolipidemic effects of and extracts.

In this study, and extracts were investigated for their antioxidant, antidiabetic and hypolipidemic activities individually and in combined form. HPLC, LC-MS and UPLC phytochemicals profiling identified phenolics and flavonoids as major bioactives. Antioxidant assays showed significant DPPH and ABTS radical scavenging activities, with the combined formulation (1:1 ratio) 91.

Corrigendum to "A comprehensive 3D CT based classification of intertrochanteric fracture" [J Clinic Orthopaedic Trauma 30 (2022) 101912].

[This corrects the article DOI: 10.1016/j.jcot.

The Ethnic/Racial Variations of Intracerebral Hemorrhage Genetics (ERICH-GENE) Study Protocol.

Background: Spontaneous, non-traumatic intracranial hemorrhage (ICH) is highly heritable disease. However, the identification of the genetic risk factors driving this high genetic predisposition has been limited by small sample sizes and underrepresentation of non-European populations. The ERICH-GENE study will gather and harmonize clinical, neuroimaging and genomic data on the largest and more diverse collection of ICH cases assembled to date.

Evaluation of mediators of seasonal variation in fatal strokes: a multicentre registry-based cohort study.

Objectives: How seasonal variations influence the incidence of fatal stroke remains unclear. Here, we examined potential mediators of the association between seasons and fatal strokes.

Methods: Data were prospectively collected (2014-2016) from the Sentinel Stroke National Audit Programme for admissions to four UK hyperacute stroke units.

Humidity-driven modulation of ferroelectricity in hafnia-zirconia membranes.

Ferroelectric hafnia-based compounds, known for exhibiting strong ferroelectricity in films of sub-5 nm thickness, hold significant potential for being integrated into complementary metal-oxide-semiconductor devices. Due to the polymorphic nature of hafnia, their ferroelectric properties can be modulated through various mechanisms, including defects, strain, and electrochemical states. In this study, we fabricated ultrathin freestanding hafnia membranes, free from substrate and electrode-capping effects, to explore the relationship between their intrinsic ferroelectricity and surface electrochemical state by modulating humidity conditions during scanning probe microscopy measurements.

Outcomes of Post-traumatic Infected Non-union of the Humerus Managed by Hybrid Ring Fixators.

Aims: The present study evaluated the functional and clinico-radiological outcomes of management of septic non-union of the humeral fractures managed with hybrid ring fixator. Patients and methods: A total of 18 patients with post-traumatic infected non-union of humerus were included. The mean age was 30.

'Nanotechnology-based implants: recent advances and future prospects for a range of diseases'.

This is the goal of bio-implant engineering, which seeks to develop sophisticated biomaterials that can replace or augment lost or impaired tissue, and most importantly, replace the function of failed organs. Novel developments in nanotechnology have brought nanomaterials that mimic natural tissues, especially in terms of wettability, topographical, and energy states to act as a complementary substitute to the native tissues for biomedical implants. Theses nanomaterials, such as functional nanocoatings and nanostructured surfaces, enhance implant integration by offering highly effective antibacterial properties; and stimulating cell attachment, differentiation and proliferation.

Phytosomes: Advancing Herbal Medicine Through Innovative Integration.

Phytosomes are innovative lipid-viable complexes that combine phospholipids with standardized plant extracts or phytoconstituents to enhance absorption and bioavailability. This research underscores the historical importance of medicinal plants in traditional healing, especially in developing countries, highlighting the global impact of this study. The study explores the complex processes behind phytosome technology, detailing their structure, formation, and biological attributes.

Lipoic acid assisted microwave based synthesis of Au-Ag nanoclusters with tunable fluorescence for antimicrobial and bioimaging applications.

This study reports on the pioneering synthesis and application of monometallic lipoic acid (LA) stabilized gold nanoclusters (LA@AuNCs) and bimetallic gold-silver nanoclusters (LA@Au-AgNCs) fabricated via a novel microwave-assisted method. The synthesis process unveils a significant augmentation in the quantum yield of LA@AuAgNCs up to 7.9-fold compared to their monometallic counterparts (LA@Au NCs), showcasing the efficacy of the novel microwave-assisted fabrication methodology.

Functional Outcome of Intra-Articular Distal Humerus Fracture Fixation by Orthogonal Plating - In Indian Population: A Case Series.

Introduction: The study aimed to evaluate the functional outcomes by treating intra-articular distal humerus fractures using orthogonal plating, with or without olecranon osteotomy. The evaluation criteria included Mayo Elbow Performance score (MEPS), range of motion, and complications arising from surgical management.

Materials And Methods: This is a retrospective study of 34 intra-articular distal humerus fractures (AO classification type C) admitted at our institution for 2 years, 6 months from May 2021 to September 2023, all treated with orthogonal plating.

Traumatic Greater Trochanteric Avulsion with Obturator Dislocation of Hip Joint: A Unique Case Report and Review of Literature with 3-Year Follow-up.

Introduction: Anterior hip dislocations are less common in orthopedic casualties than posterior and are associated with concurrent injuries such as acetabulum fracture, femoral head fracture, or unstable pelvic injuries. Rarer still, is the obturator dislocation of the hip, with only a handful cases described in the literature with no established treatment protocols.

Case Report: We treated a young male injured in a car accident and sustained an anterior hip dislocation (obturator type) with a concomitant fracture of the ipsilateral greater trochanter.

Unraveling PPARβ/δ nuclear receptor agonists a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and anti-steatotic validation.

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors with a crucial regulatory role in carbohydrate and lipid metabolism and are emerging druggable targets in "metabolic syndrome" (MetS) and cancers. However, there is a need to identify ligands that can activate specific PPAR subtypes, particularly PPARβ/δ, which is less studied compared with other PPAR isoforms (α and γ). Herein, using the drug-repurposing approach, the ZINC database of clinically approved drugs was screened to target the PPARβ/δ receptor through high-throughput-virtual-screening, followed by molecular docking and molecular dynamics (MD) simulation.

Tuberculous osteomyelitis masquerading as tumors and tumor-like lesions: A clinico-radiological study of 20 patients.

Background: Tuberculous osteomyelitis is uncommon and may present with varied clinical and radiological presentations. This study aimed to elaborate on how these lesions mimicked different tumors or tumor-like lesions and their successful outcome with antitubercular therapy (ATT).

Methods: A retrospective review of 20 patients with tuberculous osteomyelitis who presented as tumors or tumor-like lesions of bone in the last 10 years.

Non-alcoholic fatty liver disease (NAFLD) and its association to cardiovascular disease: A comprehensive meta-analysis.

Background: Non-alcoholic fatty liver disease (NAFLD) affects up to nearly a third of the Western population and has been inconsistently associated with cardiovascular diseases (CVDs). Therefore, we conducted a comprehensive meta-analysis to quantify the correlation of NAFLD with all major vascular diseases, acute coronary syndrome (ACS), subclinical atherosclerosis and endothelial dysfunction.

Methods: We searched PubMed and Embase for studies looking at the relationship between NAFLD and cardiovascular diseases published through September 2023.

Lotilaner for Demodex Blepharitis: The Journey from Veterinary Use to Human Medicine.

In 2023, Xdemvy® (0.25% lotilaner ophthalmic solution) was approved by the U.S.

Exploring USFDA-Approved Imidazole-Based Small Molecules in Drug Discovery: A Mini Perspective.

In the present work, we have explored the importance of the imidazole ring and its importance in drug discovery, citing the key approvals in the present decade (2013-2024). The pharmacological attribution for the approved drugs revealed that out of 20 approved drugs, 45% of the approvals were made as anti-infectives, followed by approvals under the category of genetic and metabolic disorders, sexual endocrine disorders, anticancer, and to treat blood pressure, gastrointestinal disorders, and neurological conditions. Most approved drugs were dispensed through solid dosage forms (13) and thus had predominantly oral routes beside others.

Off-label use of the pipeline embolization device for reconstruction of the extracranial internal carotid artery.

Background: Internal carotid artery dissection (ICD) is a common cause of cerebral ischemia in adults. Medical management has been the standard of care; however, endovascular internal carotid artery (ICA) reconstruction has certain indications. The pipeline embolization device (PED) is a flow-diverting (low porosity), self-expanding, braided platinum and nickel-cobalt chromium alloy stent and is indicated for wide neck or large aneurysms of the ICA from the petrous to the superior hypophyseal segments.