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Introduction: Positive psychological interventions (PPIs) can help mitigate psychological challenges and facilitate the transition to higher education.
Methods: This study presents the results of a quasi-experimental trial of a 6-week universal, multicomponent PPI designed specifically for university students. It compares survey responses of intervention group participants with those of passive control group participants before, immediately after, and 6 months after the intervention.
Results: The results show that the PPI led to significant improvements in mindfulness, positive reframing, and self-compassion at the trait level, and in self-compassion, positive affect, relaxation, subjective physical health, and subjective sleep quality at the state level.
Discussion: The study demonstrates that PPIs can effectively build psychological resources during educational transitions, particularly those related to emotion regulation. However, other resources and outcomes (e.g., character strengths) were less affected. Thus, more tailored approaches and selective interventions are recommended to address these areas comprehensively and ensure a more holistic improvement in student wellbeing.
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http://dx.doi.org/10.3389/fpsyg.2025.1631713 | DOI Listing |
Dig Dis Sci
September 2025
Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Background And Aims: Liver metastasis significantly contributes to poor survival in patients with colorectal cancer (CRC), posing therapeutic challenges due to limited understanding of its mechanisms. We aimed to identify a potential target critical for CRC liver metastasis.
Methods: We analyzed the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) databases and identified EphrinA3 (EFNA3) as a potential clinically relevant target.
J Chem Theory Comput
September 2025
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Department of Pharmaceutical Sciences, Institute of Chemical Process Systems Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Organometallic catalysis lies at the heart of numerous industrial processes that produce bulk and fine chemicals. The search for transition states and screening for organic ligands are vital in designing highly active organometallic catalysts with efficient reaction kinetics. However, identifying accurate transition states necessitates computationally intensive quantum chemistry calculations.
View Article and Find Full Text PDFJ Phys Chem B
September 2025
Department of Chemistry, IIT Jodhpur, Jodhpur, Rajasthan 342037, India.
The dynamics of the aggregated light-harvesting complex (LHCII) associated with its antenna pigments can be crucial for a transition between light-harvesting and dissipative states, which is pivotal for nonphotochemical quenching (NPQ). To this end, aggregation of pigment-binding LHCII monomers and PsbS-associated trimers in neutral and low lumenal pH respectively, has been investigated when embedded in the plant thylakoid membranes, using coarse-grained molecular dynamics simulations. Both pigment-binding LHCII monomers and PsbS-associated trimers dynamically form and break dimers and higher-order aggregates in thylakoids within the simulation time.
View Article and Find Full Text PDFAnn Neurol
September 2025
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Objective: The objective of this study was to determine the predictive value of amyloid-positron emission tomography (PET) versus the plasma ratio of phosphorylated tau at threonine 217 (p-tau217) to non-phosphorylated tau217 (%p-tau217) for tau-PET transitions (T- to T+). The added value of combining plasma amyloid-β 42 and amyloid-β 40 (Aβ42/40) and %p-tau217 into an amyloid probability score (APS2) was also assessed.
Methods: Mayo Clinic Study of Aging (MCSA) participants had plasma markers measured at via mass spectrometry (MS), an amyloid-PET scan, and a tau-PET (meta-temporal region of interest [ROI]) negative scan (standardized uptake value ratio [SUVR] <1.
Alzheimers Dement (Amst)
September 2025
Introduction: Simple screening tools are critical for assessing Alzheimer's disease (AD)-related pre-dementia changes. This study investigated longitudinal scores from the Quick Dementia Rating System (QDRS), a brief study partner-reported measure, in relation to baseline levels of the AD biomarker plasma pTau217 in individuals unimpaired at baseline.
Methods: Data from the Wisconsin Registry for Alzheimer's Prevention (N = 639) were used to examine whether baseline plasma pTau217 (ALZpath assay on Quanterix platform) modified QDRS or Preclinical Alzheimer's Cognitive Composite (PACC3) trajectories (mixed-effects models; time = age).