Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: The low solubility and permeability of tetrahydrocurcumin act as a barrier in its therapeutic effectiveness, particularly in the topical treatment of skin diseases like psoriasis.
Method: Niosomes were prepared using thin-film hydration method using span 60, cholesterol as independent variables in Box Behnken design. Particle size, entrapment efficiency and drug loading were taken as dependent variables. In Box Behnken design the levels are -1, 0, and +1. The values for span 60 are 50, 75, and 100mg and for cholesterol 10, 20, and 30mg.
Results: The optimized formulation has a particle size of 116.9 nm, entrapment efficiency of 94.7% and, drug loading of 85.23%. The niosomes showed first-order release kinetics property and maintained stability at 4℃ and 25℃ for three months. The desirability score obtained was 0.896.
Discussion: The optimized niosomal formulation enhanced THC's solubility, permeability, and stability, supporting its potential for effective topical psoriasis treatment. Future studies will focus on in situ gel incorporation and in vivo validation.
Conclusion: The developed formulation significantly improves the solubility and permeability of tetrahydrocurcumin which leads to improved therapeutic effectiveness in the formulation for the treatment of psoriasis. Further studies will incorporate these niosomes in in situ gels for the application.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/0118715230385381250807024537 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Particle size-dependent antibacterial activity of emodin nanocrystals against Staphylococcus aureus.
Int J Pharm
September 2025
Department of Pharmacy, The First Hospital of China Medical University, Shenyang 110001, China. Electronic address:
Emodin is a natural anthraquinone derivative with poor water solubility, which limits its antibacterial activity. The purpose of this work is to investigate the antibacterial activity of emodin nanocrystals (EMD-NCs) with different particle sizes against Staphylococcus aureus (S. aureus) and explores its underlying mechanisms.
View Article and Find Full Text PDFEstablishing clinically relevant dissolution specifications for prodrug bioequivalence risk assessment: Integration of a dissolution/permeation system with physiologically based biopharmaceutics modeling in abiraterone acetate.
Eur J Pharm Biopharm
September 2025
Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China. Electronic address:
Prodrugs with enzymatic activation requirements, such as the weakly basic biopharmaceutical classification system (BCS) class IV compound abiraterone acetate (ABA), face considerable bioequivalence (BE) risks owing to their pH-dependent solubility, food effects, and variable intestinal hydrolysis. This study established clinically relevant dissolution specifications for ABA using biorelevant dissolution and physiologically based biopharmaceutics modelling (PBBM). Two dissolution methods, two-stage (gastrointestinal transfer simulation) and single-phase (biorelevant media), were evaluated under fasted and fed conditions.
View Article and Find Full Text PDFStarch-based biopolymer films with nitrogen-doped carbon quantum dots for enhanced barrier functions via surface microarchitectures.
Int J Biol Macromol
September 2025
Department of Nanoscience and Nanoengineering, Istanbul Technical University, 34469, Maslak, Istanbul, Turkey; Department of Chemistry, Faculty of Science and Letters, Istanbul Technical University, 34469, Maslak, Istanbul, Turkey. Electronic address:
This study presents the development of multifunctional starch-based biopolymer films reinforced with nitrogen-doped carbon quantum dots (N-CQDs), synthesized via a hydrothermal method, and exhibiting a high quantum yield (~70 %). N-CQDs were incorporated into the starch matrix at varying concentrations (0.1-1.
View Article and Find Full Text PDFDistinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis.
Nat Immunol
September 2025
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Crohn's disease pathology is modeled in TNF mice that overproduce tumor necrosis factor (TNF) to drive disease through TNF receptors. An alternative ligand for TNF receptors, soluble LTα, is produced by B cells, but has received scarce attention because LTα also partners with LTβ to generate membrane-tethered LTαβ that promotes tertiary lymphoid tissue-another feature of Crohn's disease. We hypothesized that B cell-derived LTαβ would critically affect ileitis in TNF mice.
View Article and Find Full Text PDFFrom a traditional medicine monomer to a modern neurotherapeutic scaffold: a review of SAR-Driven tetramethylpyrazine derivatives for cerebrovascular and cognitive health.
Front Pharmacol
August 2025
Department of Neurology, Clinical Neuroscience Center, The 7th Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
Tetramethylpyrazine (TMP), a bioactive alkaloid isolated from the traditional Chinese medicine (, has gained significant attention for its therapeutic potential in cerebrovascular diseases and cognitive impairment, mainly due to its antioxidant, anti-inflammatory, and anti-apoptotic properties. However, its clinical application is often limited by suboptimal pharmacokinetic characteristics and modest potency. This review highlights recent advancements in the structure-activity relationship (SAR) optimization of TMP, focusing on its derivatives' neuroprotective efficacy and vascular benefits.
View Article and Find Full Text PDF