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Non-palpable migrated contraceptive implants pose significant challenges for removal and are associated with neurovascular complications. Traditional open surgery near nerves is associated with postoperative morbidity. Migrated or deeply embedded implants near critical structures can result in severe complications, such as neuropathy, and their removal typically requires open surgical intervention. We report a novel, minimally invasive, ultrasound (US)-guided technique for removing a migrated etonogestrel Implanon implant that caused ulnar neuropathy. A 38-year-old woman presented with severe neuropathic pain and paresthesia (NPRS 10/10; QuickDASH 55) along her left ulnar nerve following multiple failed removal attempts that induced deep migration. US confirmed the proximity of the implant to the ulnar nerve. Initial US-guided removal exacerbated her symptoms. Hydrodissection (HD) with 50 mL of 5% dextrose in water (D5W) without local anesthetic (LA) was performed to reduce inflammation and achieve separation. The implant migrated proximally during extraction. An additional HD with 50 mL of D5W without LA distally repositioned the implant. Percutaneous stabilization using a 25-gauge needle enabled secure removal. The intact 4 cm implant was extracted under real-time US guidance without open surgery. The patient experienced immediate symptom relief (NPRS 2/10; QuickDASH 4.5 at one month) and full resolution (NPRS 0/10; QuickDASH 0) with no motor deficits at one year. This case represents the first documented percutaneous removal of a nerve-adherent implant using combined US-guided D5W HD and needle stabilization, marking a paradigm shift in the management of such cases. This approach confirms the safety of US-guided foreign body removal using HD for nerve-adjacent implants and demonstrates the efficacy of combining D5W HD with needle stabilization. Surgical morbidity was avoided, while excellent long-term outcomes were achieved.
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http://dx.doi.org/10.3390/diagnostics15162106 | DOI Listing |
ACS Omega
September 2025
Australian Nuclear Science and Technology Organisation, Locked Bag 2001, Kirrawee DC, NSW 2232, Australia.
We report the hydrothermal syntheses and structural and spectroscopic characterization of two new uranium oxide hydrate frameworks (UOHFs) with either Pr or Nd ions, Pr(HO)[(UO)UO(OH)] () or Nd(HO)[(UO)UO(OH)] (). Both UOHFs crystallize in the orthorhombic 222 space group and display needle crystal morphologies. Their crystal structures are composed of β-UO-type layers connected by double uranium polyhedra to form the frameworks, with disordered Pr/Nd ions within the framework channels, as revealed by synchrotron single-crystal XRD.
View Article and Find Full Text PDFRecent Adv Drug Deliv Formul
August 2025
Swami Devi Dyal Group of Professional Institute, Panchkula, India.
For centuries, injections have been the primary method for vaccination; however, these traditional approaches present challenges due to pain, fear, and difficulties in administration. Scientists from Stanford University have developed vaccine creams, representing a revolutionary approach to the field of vaccination. Genetically modified Staphylococcus epidermidis forms the basis of these cream products, which support skin-based, painless vaccination without invasive procedures, while playing an essential role in the immune response.
View Article and Find Full Text PDFIJU Case Rep
September 2025
Introduction: The diagnosis of systemic transthyretin amyloidosis based on prostate biopsy is very rare, and we report this case with a literature review.
Case Presentation: A 73-year-old male patient was referred to our department due to an increased serum prostate-specific antigen level at 10.4 ng/mL while receiving benign prostatic hypertrophy treatment.
J Am Chem Soc
September 2025
Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Understanding and controlling the nucleation and growth processes of gold clusters are crucial for advancing the nucleation theory and targeted cluster synthesis. While mass spectrometry has revealed the intermediate species formed during the growth process, the overall structural evolution remains unclear due to a lack of crystallographic information. In this study, we examined a new synthetic method for thiolate-protected gold clusters in their embryonic stage.
View Article and Find Full Text PDFAnal Chim Acta
October 2025
Shanghai Frontier Science Research Center for Advanced Textiles, College of Textiles, Donghua University, Shanghai, 201620, China; Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China. Electronic address:
Background: Blood glucose monitoring is of paramount importance for patients with diabetes. However, conventional glucose meters exhibit limited accuracy and present challenges for prolonged use, primarily due to the high consumption of glucose oxidase (GOD) and their sensitivity to temperature and environmental factors. phenylboronic acid (PBA), benefiting from its reversible reaction with glucose and superior stability, holds potential as a promising medium for long-term glucose monitoring.
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