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Objective: To evaluate the safety and clinical utility of the corrected Modified Early Warning Score (MEWS) system in predicting postoperative clinical deterioration and long-term prognosis in neurosurgical patients.
Methods: A prospective cohort study was conducted on 344 neurosurgical patients admitted between December 2021 and April 2022. Physiological parameters including axillary temperature, respiratory rate, heart rate, systolic blood pressure, arterial oxygen saturation, and consciousness level were systematically recorded. Patients were monitored for clinical deterioration and final outcomes over a 90-day postoperative period. Receiver operating characteristic (ROC) curve analysis was performed with 90-day mortality as the primary endpoint.
Results: The study demonstrated a significant correlation between elevated corrected MEWS scores and clinical severity (p<0.001). ROC analysis revealed excellent predictive accuracy for 90-day mortality (AUC=0.944), with an optimal cutoff value of 4.5 points demonstrating high sensitivity (92.9%) and specificity (82.0%). The maximum Youden's index of 0.749 further confirmed the robust discriminative capacity of this threshold.
Conclusion: The corrected MEWS scoring system shows strong predictive validity for postoperative clinical deterioration and long-term outcomes in neurosurgical patients.
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http://dx.doi.org/10.2147/RMHP.S532103 | DOI Listing |
Nat Metab
September 2025
Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, UK.
Young-onset monogenic disorders often show variable penetrance, yet the underlying causes remain poorly understood. Uncovering these influences could reveal new biological mechanisms and enhance risk prediction for monogenic diseases. Here we show that polygenic background substantially shapes the clinical presentation of maturity-onset diabetes of the young (MODY), a common monogenic form of diabetes that typically presents in adolescence or early adulthood.
View Article and Find Full Text PDFJ Breath Res
September 2025
Department of Anatomy, Physiology, and Cell Biology, , University of California Davis, School of Veterinary Medicine, Davis, California, 95616-5270, UNITED STATES.
Millions of people worldwide are exposed to environmental arsenic in drinking water, resulting in both malignant and nonmalignant diseases. Interestingly, early life exposure by itself is sufficient to produce higher incidences of these diseases later in life. Based on the delayed onset of disease, we hypothesized that early life arsenic exposure would also induce long-term alterations in the metabolic profile.
View Article and Find Full Text PDFSeizure
August 2025
Serviço de Neurologia, Departamento de Neurociências e Saúde Mental, Hospital Santa Maria, Unidade Local de Saúde Santa Maria, Lisboa, Portugal; Centro de Estudos Egas Moniz, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal; Laboratório de EEG/Sono, Serviço de Neurologi
Introduction: Subtle involuntary movements in patients with impaired awareness may suggest non-convulsive status epilepticus (NCSE), but their diagnostic accuracy is unclear. Since electroencephalography (EEG) is not always available, clinicians often rely on motor signs for early diagnosis. We aimed to characterize these movements and evaluate interrater agreement and diagnostic accuracy among specialists.
View Article and Find Full Text PDFTalanta
September 2025
School of Pharmaceutical Science, Zhengzhou University, Zhengzhou, 450001, China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou, 450001, China. Electronic address:
Acute kidney injury (AKI) is a swiftly advancing condition that may result in kidney failure and pose a significant threat to life. Therefore, diagnosis of AKI is crucial for treating AKI and preventing the worsening of the condition. We developed a near-infrared fluorescent probe, CyO@CD-Ser, designed for the diagnosis of AKI.
View Article and Find Full Text PDFSTAR Protoc
September 2025
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture, Northwest A&F University, Yangling 712100, China. Electronic address:
High-throughput chromosome conformation capture (Hi-C) provides genome-wide insights into chromatin interactions within the three-dimensional structure of the nucleus, making it a powerful tool for studying genome architecture. Here, we provide a modified in situ Hi-C protocol for small cell numbers, utilizing 50-100 embryonic cells at the 8-cell stage to investigate chromatin organization during bovine early embryonic development. This protocol overcomes the challenges of limited sample availability and offers valuable insights into chromatin dynamics during bovine early embryogenesis.
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