Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Bile reflux gastritis (BRG) may lead to precancerous lesions of gastric cancer and gastric cancer. Although ursodeoxycholic acid (UDCA) has been used to treat BRG, its clinical efficacy remains unknown. Therefore, we systematically evaluated the efficacy and safety of UDCA compared with conventional therapy for BRG.
Methods: We selected candidate studies and generated a forest plot to evaluate outcomes. Metaregression analysis was conducted to identify possible explanations for heterogeneity. Study quality was evaluated using the Cochrane Risk of Bias 2 tool and the Newcastle-Ottawa scale. The quality of evidence for the outcomes of the meta-analysis was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach.
Results: A total of 14 studies including 1605 patients were identified. Compared with control groups, medication combined with UDCA significantly reduced the number of reflux episodes [mean difference (MD) = - 17.99 times, 95% CI (- 19.84, - 16.14)], shortened the longest duration of reflux [MD = - 9.21 min, 95% CI (- 12.63, - 5.80)], decreased the number of long reflux episodes [MD = - 3.21 times, 95% CI (- 3.76, - 2.66)], increased the clinical response rate [risk ratio = 1.15, 95% CI (1.10, 1.19)], decreased the gastrin content [MD = - 18.03 ng/L, 95% CI (- 33.88, - 2.18)] and alleviated symptoms.
Conclusions: UDCA demonstrates significant therapeutic efficacy for BRG, particularly with 8-week regimens, supporting its potential as a first-line therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10620-025-09334-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dupilumab monotherapy in super-elderly patients with bullous pemphigoid: a retrospective study on long-term efficacy and safety in mild to moderate cases.
J Dermatolog Treat
December 2025
Department of Dermatology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Background: Bullous pemphigoid (BP) is a common autoimmune subepidermal bullous disease. Dupilumab, an IL-4/IL-13 inhibitor, represents a novel therapeutic approach for BP, but real-world long-term data in super-elderly patients are limited.
Methods: This retrospective, single-center observational study included super-elderly BP patients (≥80 years) receiving dupilumab monotherapy from September 2022 to September 2024.
Estimands for Early-Phase Dose Optimization Trials in Oncology.
Biom J
October 2025
Novella Clinical Full Service, IQVIA, Melbourne, Australia.
Phase I dose escalation trials in oncology generally aim to find the maximum tolerated dose. However, with the advent of molecular-targeted therapies and antibody drug conjugates, dose-limiting toxicities are less frequently observed, giving rise to the concept of optimal biological dose (OBD), which considers both efficacy and toxicity. The estimand framework presented in the addendum of the ICH E9(R1) guidelines strengthens the dialogue between different stakeholders by bringing in greater clarity in the clinical trial objectives and by providing alignment between the targeted estimand under consideration and the statistical analysis methods.
View Article and Find Full Text PDFThe trial design of the concurrent optical and magnetic stimulation (COMS) therapy study for refractory diabetic foot ulcers (MAVERICKS): a multicenter, randomized, sham-controlled, double-blind investigational device exemption clinical study.
Wounds
August 2025
Department of Nursing, Federal University of Ceará, Ceará, Brazil.
Background: Diabetic foot ulcers (DFUs) are a major clinical challenge, particularly among patients with refractory ulcers, that often lead to severe complications such as infection, amputation, and high mortality. Innovations supported by strong clinical evidence have the potential to improve healing outcomes, enhance quality of life, and reduce the economic burden on individuals and health care systems.
Objective: To describe the design of the concurrent optical and magnetic stimulation (COMS) therapy Investigational Device Exemption (IDE) study for refractory DFUs (MAVERICKS) trial.
Reimagining Outcomes: A Perspective Review of Advances in Remote Monitoring Technologies in Post-Arthroplasty Patient Care.
J Orthop Res
September 2025
Department of Kinesiology, College of Health Sciences, University of Rhode Island, Kingston, Rhode Island, USA.
Arthroplasty surgery is a common and successful end-stage intervention for advanced osteoarthritis. Yet, postoperative outcomes vary significantly among patients, leading to a plethora of measures and associated measurement approaches to monitor patient outcomes. Traditional approaches rely heavily on patient-reported outcome measures (PROMs), which are widely used, but often lack sensitivity to detect function changes (e.
View Article and Find Full Text PDFCompetence and control beliefs in three cultures: a German personality test applied at home, in Kenya and Poland.
BMC Psychol
September 2025
Institute of Psychology, University of Koblenz, Universitätsstraße 1, 56070, Koblenz, Germany.
Background: Competence and control beliefs are core self-evaluations with increasing value as predictors (e.g., in clinical, organizational, environmental, and educational psychology), and they are assumed to have a universal core that is shared across cultures.
View Article and Find Full Text PDF