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http://dx.doi.org/10.1038/s41591-025-03909-y | DOI Listing |
J Mater Chem B
September 2025
Department of Chemistry, Indian Institute of Technology Ropar, Rupnagar, Punjab 140001, India.
The unregulated use and improper disposal of active pharmaceutical ingredients (APIs), particularly phenylbutazone (PBZ), are contaminating water resources and posing serious risks to the food chain. PBZ is a nonsteroidal anti-inflammatory drug (NSAID) commonly used for treating pain and fever in animals, and its persistence in the environment due to inadequate waste management has become a cause of concern. To address this, we report the fabrication of benzimidazole-based self-assembled nanomicelles (R2 NMs) for selective detection and removal of PBZ.
View Article and Find Full Text PDFCochrane Database Syst Rev
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.
Background: Radiotherapy is the mainstay of treatment for head and neck cancer (HNC) but may induce various side effects on surrounding normal tissues. To reach an optimal balance between tumour control and toxicity prevention, normal tissue complication probability (NTCP) models have been reported to predict the risk of radiation-induced side effects in patients with HNC. However, the quality of study design, conduct, and analysis (i.
View Article and Find Full Text PDFThe morphological patterns of lung adenocarcinoma (LUAD) are recognized for their prognostic significance, with ongoing debate regarding the optimal grading strategy. This study aimed to develop a clinical-grade, fully quantitative, and automated tool for pattern classification/quantification (PATQUANT), to evaluate existing grading strategies, and determine the optimal grading system. PATQUANT was trained on a high-quality dataset, manually annotated by expert pathologists.
View Article and Find Full Text PDFJ Oral Biol Craniofac Res
August 2025
Neura Integrasi Solusi, Jl. Kebun Raya No. 73, Rejowinangun, Kotagede, Yogyakarta, 55171, Indonesia.
Background: Periodontal disease is an inflammatory condition causing chronic damage to the tooth-supporting connective tissues, leading to tooth loss in adults. Diagnosing periodontitis requires clinical and radiographic examinations, with panoramic radiographs crucial in identifying and assessing its severity and staging. Convolutional Neural Networks (CNNs), a deep learning method for visual data analysis, and Dense Convolutional Networks (DenseNet), which utilize direct feed-forward connections between layers, enable high-performance computer vision tasks with reduced computational demands.
View Article and Find Full Text PDFAddict Behav Rep
June 2025
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
This article proposes minimum requirements for reporting efficacy in treatment studies of compulsive sexual behavior (CSB). CSB disorder (CSBD) is a condition whose diagnostic criteria were only recently defined by the World Health Organization. Multiple primary and secondary outcomes have been used in treatment trials of CSB, and possible neuropsychological measures have been considered.
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