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Over the past decade, psychiatric wards across the Netherlands have worked in accordance with the High and Intensive Care model to reduce coercion and improve the quality of care. Securing implementation of the model within a challenging mental health care context has proven to be effective but complex in practice. Consequently, this study aimed to both gain insight into the process of implementing the High and Intensive Care model by drawing upon professionals' own reflections and provide recommendations for improving practice and the model. This is a national multicentre study that utilised qualitative methods. Data was collected by a total of 26 institutional and national group interviews on which thematic analysis was conducted. Staff turnover, coercion, collaboration with outpatient care, working methodically and the move from control to contact were found to be the key developments since the model's implementation. Future efforts should focus upon staff retention and acquisition to ensure continuity of care and safety. Ongoing evaluation of coercion is essential to further reduce coercion. Collaborations with outpatient care and other stakeholders should be intensified to promote effective care. Management support, reflexivity and a clear vision are required to strengthen methodical working and collaboration between wards to create uniformity of practice. Working in contact with patients ensures safety but requires time and behavioural change. Applying implementation science can support improvements in acute mental health care by systematically addressing barriers to change, promoting sustainable evidence-based practices, and guiding the reduction of coercion. Further research into these barriers, including the exploration of non-coercive strategies and stakeholder involvement, is needed to enhance High and Intensive Care implementation and similar practices.
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http://dx.doi.org/10.1111/inm.70120 | DOI Listing |
Neurol Sci
September 2025
Pediatric Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Background: super-refractory status epilepticus (SRSE) is a rare and severe neurological condition associated with high mortality and significant long-term morbidity. In many cases, conventional medical treatments prove ineffective, with wide use of off-label therapies.
Methods: two researchers conducted a review of the medical records of subjects who had undergone VNS implantation in our tertiary Centre.
Clin Res Cardiol
September 2025
Department of Cardiology, University Heart Center, University Hospital Zurich, Center for Translational and Experimental Cardiology (CTEC), University of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland.
Background: Diabetic patients with ST-segment elevation myocardial infarction (STEMI) are at an increased risk of cardiovascular events as compared to non-diabetic patients. This analysis investigated outcomes of diabetic patients presenting with multivessel disease (MVD) and STEMI in a contemporary trial and the relevance of an immediate versus staged multivessel PCI strategy in this high-risk population.
Methods: Patients enrolled in the MULTISTARS AMI trial were stratified according to the presence/absence of diabetes.
Eur Heart J
September 2025
Medizinische Klinik und Poliklinik II, Universitätsklinikum Bonn, Venusberg-Campus 1, Bonn 53127, Germany.
Background And Aims: Fulminant myocarditis (FM) is a complex clinical syndrome characterized by acute myocardial inflammation and cardiogenic shock. Evidence on long-term outcomes, mortality risk factors, and targeted treatment options remains limited.
Methods: This retrospective analysis included consecutive adult patients admitted for FM between January 2012 and November 2022 at 26 European tertiary centres.
J Chem Theory Comput
September 2025
State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering, Department of Pharmaceutical Sciences, Institute of Chemical Process Systems Engineering, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China.
Organometallic catalysis lies at the heart of numerous industrial processes that produce bulk and fine chemicals. The search for transition states and screening for organic ligands are vital in designing highly active organometallic catalysts with efficient reaction kinetics. However, identifying accurate transition states necessitates computationally intensive quantum chemistry calculations.
View Article and Find Full Text PDFJ Pediatric Infect Dis Soc
September 2025
Infectious Diseases Unit, 3rd Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Thessaloniki, Greece.
Background: Critically ill pediatric patients admitted to the PICU are highly vulnerable to infections, including invasive fungal diseases and antifungal agents are frequently prescribed. Little is known about antifungal usage in PICUs across Europe.
Methods: A multinational 3-month weekly point-prevalence study for measuring antifungal drug use was organized.