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Organophosphorus compounds, widely used as flame retardants and plasticizers in plastic products, present significant health risks due to their potential adverse effects. While inhalation and ingestion are well-studied exposure pathways, dermal exposure remains underexplored. In recent years, the growing popularity of gamingdriven by extended home stays during the COVID-19 pandemic and the inclusion of e-sports in international competitionshas led to prolonged contact with gaming devices, particularly among young people and professional gamers. This study investigates dermal exposure to triphenyl phosphate (TPhP) from 37 home-use video game controllers. TPhP was detected in 5 first-party and 22 third-party controllers, with concentrations reaching up to 530 μg g. Using artificial skin (EPISKIN), we measured a TPhP skin permeation rate of 0.42 ng cm h. Monte Carlo simulations were used to estimate daily dermal intake rates; professional gamers (5th percentile-50th percentile-95th percentile, 9.0-22-45 ng kg day) and e-sports students (5.3-8.5-18 ng kg day) were identified as the most exposed groups due to prolonged gaming sessions. Remarkably, dermal exposure from the controller was found to rival or exceed other pathways, including dust ingestion and inhalation. This study highlights the urgent need for strategies to mitigate dermal exposure risks from gaming devices.
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http://dx.doi.org/10.1021/envhealth.5c00065 | DOI Listing |
Sci Total Environ
September 2025
MOE Key Laboratory of Pollution Processes and Environmental Criteria, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:
The widespread application of chemical additives in textiles raises concerns about dermal exposure, especially in children. We analyzed 28 per- and polyfluoroalkyl substances (PFAS) and 9 organophosphate esters (OPEs) in household textiles and children's garments. PFAS were detected in 87.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Centro Médico Nacional Siglo XXI, Mexico City, MEX.
Acute generalized exanthematous pustulosis (AGEP) is a rare, potentially severe cutaneous adverse reaction characterized by the rapid onset of numerous small, sterile pustules on edematous erythema, commonly accompanied by systemic symptoms such as high-grade fever and neutrophilic leukocytosis. AGEP is most frequently triggered by medications, especially antibiotics, though infections and other exposures can also be causative. We report the case of a previously healthy 27-year-old male patient who developed a febrile pustular eruption with systemic involvement.
View Article and Find Full Text PDFBiomater Adv
September 2025
Department of Applied Science and Technology (DISAT), Politecnico di Torino, Corso Duca Degli Abruzzi 24, 10129 Torino, Italy.
Tailoring surface characteristics is key to guiding scaffold interaction with the biological environment, promoting successful biointegration while minimizing immune responses and inflammation. In cardiac tissue engineering, polyvinylidene fluoride (PVDF) is a material of choice for its intrinsic piezoelectric properties, which can be enhanced through electrospinning, also enabling the fabrication of nanofibrous structures mimicking native tissue. However, the inherent hydrophobicity of PVDF can hinder its integration with biological tissues.
View Article and Find Full Text PDFEnviron Pollut
September 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China; Zhejiang Key Laboratory of Environment and Health of New Pollutants, School of Environment, Hangzhou Institute for Advanced Study, U
Per- and polyfluoroalkyl substances (PFAS) are extensively used in the petrochemical industry and pose considerable risks to the environment. However, systematic research on PFAS contamination in petrochemical industrial parks remains limited. This study focused on the occurrence, spatial distribution, and sources of 20 typical PFAS in soil (n = 19) and groundwater (n = 13) samples from a petrochemical industrial park in China.
View Article and Find Full Text PDFFood Chem Toxicol
September 2025
Science Strategies, LLC, PMB 1111, 2795 E. Cottonwood Parkway, Suite 300, Salt Lake City, UT 84121.
Tetrabromobisphenol A (TBBPA) is the most extensively used brominated flame retardant worldwide, primarily employed reactively in printed circuit boards and additively in plastic housings of electronic equipment. This study systematically evaluates human exposure to TBBPA from electronic devices and characterizes associated risks. A targeted literature review of 55 peer-reviewed studies published over the past 25 years was conducted, focusing on global TBBPA occurrence in environmental media, occupational and residential settings, and biological matrices.
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